Patrick Sanger, MD, PhD

@lipo_fan @LowCarbEyeDoc @realDaveFeldman @JohnKastelein @stathitriadis @JesperLundbom @nicknorwitz Note that some studies included in this graphic represent only FH populations, primary prevention, secondary prevention etc. They all fall on the same regression line. academic.oup.com/eurheartj/arti…

@lipo_fan @LowCarbEyeDoc @realDaveFeldman @JohnKastelein @stathitriadis @JesperLundbom @nicknorwitz Yes, but not due to uniquely pathologic mutations but rather cumulative lifetime exposure to ApoB. See the figure from Ference which to me conclusively demonstrates that it doesn’t matter how you raise or lower ApoB (with some unique exceptions eg niacin).

Random musings If it matters how you lower your LDL why doesn’t it matter how you raise your LDL? @nicknorwitz @realDaveFeldman

@lipo_fan @LowCarbEyeDoc @realDaveFeldman @JohnKastelein @stathitriadis @JesperLundbom @nicknorwitz This illustration is misleading without context. FH carriers have a lifetime of exposure. From the abstract: “In an analysis of participants with serial lipid measurements over many years, FH mutation carriers had higher cumulative exposure to LDL cholesterol than noncarriers.”

@LowCarbEyeDoc @realDaveFeldman @JohnKastelein @stathitriadis @JesperLundbom @nicknorwitz I was referring to Dave's analogy as being wrong, with the understanding that he is consciously making it wrong to make it easy for people. Regarding the comparison of FH with LMHR, it is essentially wrong. With nuances to comment..., we saw it with Khera et al. in 2016

Has @mcuban and @costplusdrugs considered partnering with @valisure (or other high throughput analytical lab) to check every batch of generics to verify dosage of active ingredient and screen for contaminants? I would be directing all of my patients to @costplusdrugs if so!

@Bob_Wachter Bob, recommend you try a more comfortable N95 such as 3M Aura or Kimberly Clark Pouch Style. I wear these all day and find them much more comfortable than KN95 (due to ear loops) or the old school rigid 3M.

f) When I mask, I figure I might as well wear a good one. So I generally wear a KN95 (I wear a fitted N95 when taking care of Covid patients in the hospital, but it’s too uncomfortable for prolonged and routine use). (11/25)

Making decisions about how cautious (or not) to be w/ Covid remains challenging. In this 🧵, I’ll describe my current approach. For me, with today's #'s, I find there's only 1 tough call, though it’s clear that most folks disagree – they’ve ditched their masks & moved on. (1/25)

Our #mhealth mPOWEr team highlighted @uwc4c innovator recognition event! @UWMedicineNews

At @uwc4c innovator recognition event. My hands holding #mPOWEr prototype! Thanks to CGF for $! @uwnews