Perrimon Lab

Petsakou, A., Filine. E., Li, M., Zheng, A., and Perrimon, N. (2026) Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms. Nature Communications. doi: 10.1038/s41467-026-70074-2. PMID: 41792134

Lane, E., Petsakou, A., Liu, Y., Chen, W., Qadiri, M., Hu, Y. and Perrimon, N. (2026) Cholinergic signaling modulates intestinal pathophysiology in a Drosophila model of cystic fibrosis. PloS Genetics. 22(2):e1012048. doi: 10.1371/journal.pgen.1012048. PMID: 41701793

Ewen-Campen, B., Chen, W., Tattikota, S. G., Liu, Y., Hu, Y. and Perrimon, N. (2026) The Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth. doi: doi.org/10.1101/2025.0…. Nat Comm. PMID: 41593082

Moon, Hu, Dzieciatkowska, Kim, Asara, D'Alessandro and Perrimon (2026) Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels. Nat Comm. doi: 10.1038/s41467-026-68395-3.

Marques et al. (2025) In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila. eLife14:RP109422https://doi.org/10.7554/eLife.109422.1

Lin, Deng, Gao, Tan, Zhong, Tan, Tan, Virshup, Bosch, Perrimon and Wang (2026) Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila. Nat. Comm. doi: 10.1038/s41467-025-66727-3. PMID: 41298547

Mameli, Samantsidis, Viswanatha, Kwon, Hall, Butnaru, Hu., Y., Mohr, Perrimon and Smith (2025) A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes. 16(1):10323. doi: 10.1038/s41467-025-65304-y. PMID: 41285753

Huang, K. and Perrimon, N. (2025) Metabolic command centers in Drosophila: How the fat body and oenocytes orchestrate immunity, reproduction, and aging. Current Opinion in Insect Science. 101459. doi: 10.1016/j.cois.2025.101459. PMID: 41218693

New paper Phage display-mediated immuno-PCR to detect low-abundance secreted proteins in Drosophila Han, Xia, Ah-Ram Kim, Filine, Stoneburner, Miao, Liu, Zirin, Perrimon bioRxiv 2025.10.31.685841; doi: doi.org/10.1101/2025.1…

New paper: A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome Kim, Huang, Johnson, Yaron-Barir, Keven Wang, Cantley, Hu, Perrimon bioRxiv 2025.10.10.681672; doi: doi.org/10.1101/2025.1…

New paper: A family of lethal exotoxins defined by cell entry via the Attractin receptor Viswanatha, Lee, Robins, Mameli, Hu, Kim, Hashmi, Hiroshi , Prakash, Butnaru, Churchman, Mohr, Mekalanos, Perrimon doi: doi.org/10.1101/2025.1…

New paper: Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer Liu, Miao, Wang, Ezequiel, Kim, Zhang, Sun, Binari, Asara, Hu, Goncalves, Janowitz, Perrimon doi: doi.org/10.1101/2025.1…

thecrimson.com/article/2025/9… Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research

Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth Ting Miao, Ying Liu, Mujeeb Qadiri, John M. Asara, Yanhui Hu, Xiaomei Sun, Christian Dibble, Norbert Perrimon bioRxiv 2025.08.08.669325; doi: doi.org/10.1101/2025.0…

A Genome-wide CRISPR Screen Reveals ZDHHC8-Dependent Gαq Palmitoylation as a Key Regulator of GPCR Signaling Muhammad Ahmad, Norbert Perrimon, Raghuvir Viswanatha, Ah-Ram Kim bioRxiv 2025.08.06.668953; doi: doi.org/10.1101/2025.0…

Cheng, C., Liu, Y., Chen, Y., Li, J., Xu, W., Perrimon, N. and Song, W. (2025) The power of Drosophilain modeling cancer cachexia. Adv Exp Med Biol. 482:83-100. doi: 10.1007/978-3-031-97035-1_5. PMID: 40745137

Intersecting experimental evolution and CRISPR screens to identify novel insecticide resistance loci Marconcini, Cruchet, Goswami, Viswanatha, Butnaru, De, Roselli, Hadjieconomou, Perrimon, Mohr, Benton bioRxiv 2025.07.23.666417; doi: doi.org/10.1101/2025.0…