Resendiz Lab

@psujan1234 @LatinXChem Nice work, thanks for sharing! I had a couple of questions: 1) how does your synthesis compare to previous reports? 2) In getting 16, did you observe any of the cis-isomer? 3) in obtaining 5, how come there was no Me-addition? what is the role of MeLi? Thanks!

Hi @LatinXChem , presenting my work on "Stereoselective synthesis of the northern hemisphere of the proposed structure of extremely potent anticancer macrolide neaumycin B" at #LatinXChem24 #LatinXChemOrg #Org107 #LatinXChem #Poster

@DanielO97164932 @LatinXChem tambien: 4) cual es el siguiente paso? Gracias!

Hola, buen día @LatinXChem, les presento el trabajo titulado "Síntesis y Acoplamiento Molecular de Híbrido Tiazol-chalcona frente a Receptores asociados a la Proliferación celular" para el #LatinXChem24, categoría #LatinXChemOrg y número #Org105, saludos cordiales.

@DanielO97164932 @LatinXChem Buen trabajo, gracias por compartir. 1) cuales son los rendimientos de las 2 reacciones (individual) en el poster? a que escala estas trabajando? 2) como decidiste asignar las señales del RMN mostrado? 3) el RMN muestra algunas impurezas, como purificaste el compuesto?

@Rui4David @LatinXChem Tambien, 4) cual es el mecanismo para remover la acetona de 9 a 8? Y, cuanto se tarda esta reaccion, antes de la reduccion con NaBH4? Gracias!

@Rui4David @LatinXChem Buen trabajo, gracias! unas preguntas: 1) cual es el rendimiento final, de los procesos reportados, para obtener cyclocalopin A? 2) Y, que mejoras esperas en cuanto a rendimiento, o numero de pasos, comparado con los otros reportes? 3) En que escalas estas trabajando ahora?

@CardenasDa11606 @LatinXChem Also, 5) How did you assign the H-NMR peaks? particularly those for the methyl groups? 6) What's next? Thanks!

Hi @LatinXChem , this is my work "Hybrids based on benzofuran-biphenyl nuclei: Design, synthesis and pharmakokinetic properties" at #LatinXChem24 #LatinXChemOrg #Org094 #Synthesis #OrganicChemistry #MedicinalChemistry #Cancer #Hybrids

@CardenasDa11606 @LatinXChem Nice work! some questions: 1) Did you try the reaction with phenyl boronic acid? 2) why did you decide to optimize with the 2,5-OMe reagent? I am asking because of the low yields obtained. 3) related.. why is entry 2 the best yield? any hypothesis? 4) why only e-donating groups?

@veronicaik Buen trabajo, gracias por compartir. Preguntas: 1) por que escogiste esa secuencia? disculpa si perdi el detalle. 2) cuanto compuesto obtienes al final? 3) en el HPLC, cual es el pico en 16.1? me perdi ese detalle. 4) cual es la ventaja de poner dos peptidos en el bodipy?

1/3. Hi LatinXChem , presenting my work "Conjugados de aza-BODIPY-péptido para aplicaciones biológicas. Construcción por bloques y conjugación mediante la estrategia de química click CuAAC" at #LatinXChem24 #LatinXChemOrg #Org051

@Gerardo78742772 @LatinXChem @LabSteroids Also, 4) how does your method compare to known procedures? 5) and what is the advantage of coupling to steroid units/ (sorry if I missed that). Thanks!

Hi @LatinXChem , presenting my work "Synthesis and characterization of highly fluorescent dimers derived fromestradiol" #LatinXChem24 #LatinXChemOrg #Org031 @LabSteroids

@Gerardo78742772 @LatinXChem @LabSteroids Nice work! Some questions: 1) What scales did you use to get compounds 8, and then 9/10. 2) I imagine these are hard to purify, did you use standard chromatography? 3) have you tested the uptake, and diffusion probability, through cell membrane? speaking about compound 10.

@ChinwenduFausty @LatinXChem Also: 4) whas is the significance of your modeling? as it is likely that the conformations might change, within the binding site. Thanks!

Hi @LatinXChem, presenting my work " Molecular Docking, In Vitro Antimalarial, and Antioxidant Properties of Novel Phenylalanine Carboxamides Derivatives Bearing Sulfonamides Functionality" at #LatinXChem24 #LatinXChemOrg #Org018

@ChinwenduFausty @LatinXChem Good job! Some questions: 1) what are typical yields for both synthetic steps, and how do these compare to known procedures? 2) what scale did you use, for the rxns? 3) the shown IR seems to have a lot of overlap in the regions of interest, and hard to read, do you know why?

@vikash78_ @LatinXChem Also, 4) what are the future plans? 5) what is the effect of the halogen atoms, at position 7/2 6) do you have plans to probe your proposed mechanism? Thanks!

Hi Dear #Xmates and @LatinXChem, presenting my work ‘Palladium-Catalyzed Directed C–H Alkynylation of Carbazoles’ at #LatinXChem24 #LatinXChemOrg #LatinXChemOrg #Org001.”

@vikash78_ @LatinXChem Nice work, I had a couple of questions. 1) a limitation seems to be the use of a 2-pyridyl substituent. is that necessary? have you probed other substituents? 2) related to the above, have you probed the mechanism w/ other substituents 3) Did you prepare the alkynyl bromide

@ClaraMart83337 @LatinXChem Gracias!

@Resendizlab @LatinXChem Gracias, para el compuesto 2 el rendimiento es de 97%, para 3 depende del sustituyente, por ejemplo para 3b fue un rendimiento de 24% mientras que para el compuesto 3c es de 86%, en lo siguiente, la rx es estereoselectiva desde el compuesto 2 en tanto que no tenemos un dr para 3

Hola @LatinXChem, les presento mi trabajo titulado “Síntesis de nuevos derivados esteroidales de tipo amino- alcohol de interés biológico” #LatinXChem23 #LatinXChemOrg #Org178

@jsandovallira @LatinXChem @fergotico @LuisFPS14 @QPeterL @OrgBiomolChem @EurJOC Thanks!

@Resendizlab @LatinXChem @fergotico @LuisFPS14 @QPeterL @OrgBiomolChem @EurJOC Hil @Resendizlab, thanks for the comment.

“Hi @LatinXChem, @fergotico, @LuisFPS14, @QPeterL, presenting my work ‘Novel Synthetic Application of TEMPO Salt in the Ferrier C-Glycosylation Reaction’ at #LatinXChem23 #LatinXChemOrg #Org110 @OrgBiomolChem, @EurJOC.” Poster in PDF format: smartintex-my.sharepoint.com/:b:/g/personal…

@loiznovaes @LatinXChem @OrgBiomolChem @EurJOC @CornellChem @SongLinLab @genentech Thanks!

@Resendizlab @LatinXChem @OrgBiomolChem @EurJOC @CornellChem @SongLinLab @genentech Hi @Resendizlab, we chose BF3.Et2O as Lewis acid due its broad compatibility with functional groups that commonly appear in complex drug molecules and their fragments

@WendyArratia @LatinXChem Gracias!

@Resendizlab @LatinXChem No se usó la técnica 2D. Las asignaciones fueron solo en 1D por 13C y 1H. En realidad no son tan diferentes dado que se realizaron intercambios bioisostéricos, de amida (serie A), por urea (serie B) o por carbamato (serie C) al igual que los cambios que se realizaron en el anillo

Hola @LatinXChem ! Mi nombre es Wendy Arratia y es un placer para mi presentarles mi trabajo titulado "Diseño, síntesis y bioevaluación de N-acilpiperidinas como ligandos del receptor sigma-1".#LatinXChem23 #LatinXChem #LatinXChemOrg #Org038 #QuímicaFamacéutica

@BintuKu02300128 @LatinXChem @OrgBiomolChem @EurJOC @ACSPublications @bodipy192 @BitsChemPilani Thanks!

@Resendizlab @LatinXChem @OrgBiomolChem @EurJOC @ACSPublications @bodipy192 @BitsChemPilani Thank you so much R group is substituted at para position of the ring and the dimerization scale was done above 250 mg with the starting bodipy salt. For crystallization we used (ether:CHCl3) 4:1 ratio If was wrong, please let me know

Hi @LatinXChem, presenting my work ‘BODIPY(aryl)iodonium Salts in the Efficient Synthesis of Diversely Functionalized BODIPYs and Selective Detection of Bovine Serum Albumin’at #LatinXChem23 #LatinXChemOrg #Org005 @OrgBiomolChem @EurJOC @ACSPublications @bodipy192 @BitsChemPilani

@im_prahallad @LatinXChem @ChemCommun @OrgBiomolChem @EurJOC @HyperIodine @Photocat_papers Thanks!

@Resendizlab @LatinXChem @ChemCommun @OrgBiomolChem @EurJOC @HyperIodine @Photocat_papers Thank you! Just to correct your question, iodonium salt with thiophene succefully worked in our case ( like 3av) and it is stable also. When we are taking unsymmetrical iodonium salt, in that case only phenyl transfer happened not the thiophene one due to it is electron rich.

Hi @LatinXChem , Presenting my work on "Visible light photoredox-catalyzed arylative cyclization to access benzimidazo[2,1-a]isoquinolin-6(5H)-ones" at @ChemCommun #Org008 #LatinXChemOrg @OrgBiomolChem @EurJOC @HyperIodine @Photocat_papers