M@x R.

I am very happy to share our recent publication @NatureComms about origin licensing in budding yeast. Had a blast working with @Speck_Lab, @morvorenlowen, @KorbinianLiebl et al. at @MRC_LMS and @imperialcollege. Read about it here and 👇 1/3: rdcu.be/dRTAZ

@richvrdwulf Plan the trade, trade the plan🫡

We are in the Zone I am waiting the shift of the internal structure deep sweep interesting to be honest chill and wait for the switch no switch=no long

Check out and join us for an interesting interdisciplinary PhD project! Deadline on 10th of Jan. DNA replication and cancer research 🥹. Please RT

Looks like our enthusiastic #SFB1361 members are have a great time at the #EESReplication in Heidelberg, Germany! Have you heard their talks or visited their posters? Say hi if you spot them! #DNArepair #DNAreplication

Genome stability lab unwinding🧫🧬🔬🍻 #EESreplication

@cutts_dr Congrats Erin!!

It’s been brilliant setting up my lab in Sheffield! So much to do, and the Peak District on our doorstep will surely be distracting!

Open call for #PhD positions in the @IPPMainz! 📣 You are a motivated student interested in the topics #RNAbiology, #epigenetics, #immunology or #neurodegeneration & you want to be part of a lively, international community? Apply by 24 October. ➡️ imb.de/phd

Publication alert! 📰 Great work done by @ReuterLM on the use of high-throughput flow cytometry for analysis of cell cycle stage, replicated DNA, and chromatin-associated proteins! Read their publication here: degruyter.com/document/doi/1…

Please RT. Are you interested in performing your master thesis with us @imbmainz? We have exciting projects on nuclear myosin VI in genome stability. Details below imb.de/fileadmin/imb/… If interested please apply via the link or contact me directly.

#Mainzer Wissenschaftsmarkt 2024 🔬🧬Unser Postdoc Dr. Maximilian Reuter im Gespräch mit Prof. Dr. Mita Banerjee & Dr. Ruth Gehrmann vom Obama Institute for Transnational American Studies der @unimainz über "Healthy #Ageing zwischen Körper und Kultur".

These protocols are particularly useful for researchers interested in DNA replication related research, as they allow you to quantify DNA content, EdU incorporation and protein chromatic binding at the same time in the same tube!🔬

Here, we provide novel and advanced protocols for high-throughput multidimensional flow cytometry assays in budding yeast and human cells. For the first time, we were able to measure chromatin-bound factors in yeast by flow cytometry.

Excited to share another story from the lab out in #BiologicalChemistry. 🥳 Fantastic teamwork effort at @imbmainz @uni_mainz @sfb1361 @degruyter_pub check it out here: degruyter.com/document/doi/1…

Heute Nachmittag diskutiere ich mit Kollegen des @sfb1361 und SFB1482 über Altern: Zwischen Körper und Kultur im Herzen @mainz_de. Mit Unterstützung von @imbmainz und #UniMainz.

7./8.9.2024 - 22. #MainzerWissenschaftsmarkt auf dem Gutenbergplatz @mainz_de / #UniMainz präsentiert Projekte aus #ExzellenzclusterPRISMA+, Geo- und Altertumswissenschaften, Amerikanistik, Publizistik, Geschichte u.v.m. 👉 wissenschaftsallianz-mainz.de/wissenschaftsm… #MainzerWissenschaftsallianz

@roopesh_anand @NatureComms @Speck_Lab @morvorenlowen @KorbinianLiebl @MRC_LMS @imperialcollege Thanks Roopesh :)

@ReuterLM @NatureComms @Speck_Lab @morvorenlowen @KorbinianLiebl @MRC_LMS @imperialcollege Congratulations Max. That's great.

I am very happy to share our recent publication @NatureComms about origin licensing in budding yeast. Had a blast working with @Speck_Lab, @morvorenlowen, @KorbinianLiebl et al. at @MRC_LMS and @imperialcollege. Read about it here and 👇 1/3: rdcu.be/dRTAZ

3/3: Interestingly, these sites are characterised by specific sequences and structural features that allow curving the DNA to ease DNA insertion into the MCM2-7 hexamer. Finally we found that origins are more compact than expected, fitting everything between two nucleosomes.🧬🔬

2/3: We found that ORC and MCM2-7 have overlapping binding sites in vivo, which cause ORC redistribution across the genome upon DNA licensing. Here, ORC subsequently recognises its two binding sites while loading the MCM2-7 double hexamer.

Happy to announce our new publication in @NatureComms, spearheaded by super-talented project leader @ReuterLM . We identified that helicase loading is a self-limiting reaction supporting equal distribution of the replicative helicase across the genome. rdcu.be/dRTAZ

Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates biorxiv.org/cgi/content/sh… #biorxiv_biochem