Juan Song

Happy to share our study published online today! We reveal how a small population of aberrantly integrated adult-born new neurons can disrupt brain-wide network dynamics and ultimately impair spatial memory processing. nature.com/articles/s4138…

Happy to share our new work online today in Neuron “Segregated supramammillary-dentate gyrus circuits modulate cognitive and affective function in healthy and Alzheimer’s disease model mice” sciencedirect.com/science/articl…

We demonstrate how a high-fat diet, even short-term, can rapidly affect memory through glucose-sensitive neurons, but there are ways to reverse this and prevent long-term cognitive decline.

Excited to share our new paper, ‘Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity,’ published online in Neuron today! Congrats to all the co-authors! cell.com/neuron/abstrac…

@zenbrainest Thanks Bryan!

Cool and congrats!

@xinduan Thanks Xin!

@Songlaboratory Congratulations 🍾

Excited to share our work on cholinergic circuit regulation of adult neural stem cells through dentate granule cell intermediaries, a new mode of circuit-based regulation of adult neural stem cells in the hippocampus. pnas.org/doi/10.1073/pn…

@J_S_Farrell Thanks Jordan!!

@Songlaboratory Congrats Juan! Very cool!

@TjShors Thanks Tracy! I started this work when I was a postdoc. Finally get it published after 10 years!!

@Songlaboratory We tried to investigate this years ago. Nice to see!

@Ella_Maru Looks like it correlates with increased proliferation of neural stem cells, both symmetric self-renewal and asymmetric neurogenic division.

@Songlaboratory Congratulations Juan! How do changes in radial neural stem cell shape affect their ability to differentiate?

This is the first study from my lab dealing with sex differences, which definitely opens up more exciting science toward this direction down the road. Stay tuned!

Happy to share our recent story on “Sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells”. cell.com/cell-reports/f…

My great pleasure to host Dr. Zuhang Sheng @zuhangsheng from NIH for an inspiring seminar on mitochondrial reprogramming and energy metabolism for neuroregeneration @UNC_PHCO.

Very happy to share our latest work from the @SolteszLab co-led w/ @EHwaun now online at @Nature. We take a deep dive into a neural activity pattern known as the hippocampal "dentate spike" and its role in cognition. nature.com/articles/s4158…

Do hamsters and voles have an identifiable CA2? Why yes of course (dorsal AND ventral)! (🤫 just don’t try to use PNN labeling!)

@katlandis20 It was great to catch up with you in #Neurogen2024! Hope you are enjoying the snow :)

I had an absolutely amazing time at #Neurogen24. So many amazing talks and wonderful discussions. The sun and warmth were a nice change from Philly, which has welcomed me back with some snow!

Great to see neurogenesis folks and talks about adult hippocampal neurogenesis after a long while!

Exciting and fun meeting at #neurogen24 #Cancun @Fusion_Conf

Great collaboration with Bai lab @baiwubin! We report a technical platform to deliver drugs to the brain using spatiotemporal on-demand patch that integrates drug-loaded microneedles with biocompatible metallic membranes to enable electrically triggered control of drug release.👇

Our second-generation monosynaptic tracing paper is now online at Nature Neuroscience (open access): "Long-term labeling and imaging of synaptically connected neuronal networks in vivo using double-deletion-mutant rabies viruses" nature.com/articles/s4159… 1/12