Translational Nuclear Receptor Research Lab

🎉 Congratulations to Milton Antwi (@miltzz3) for winning a prestigious poster prize at the 2023 International Liver Congress (#EASLcongress) organized by @EASLnews in Vienna, Austria! 🌍🏆@ugent @ugent_fge @uzgent @VIB_CMB

We went to primary schools to teach about DNA & the heredity of genes for 'Science on the Road'. Children built candy DNA and performed an experiment to find out: Is it you, or your DNA that you (dis)like coriander? We hope we have inspired some of them to become scientists!

Interview by our @TNRR_Lab team members Milton Antwi and @NickDeploey !

Last month, Eleni Staessens won the Ziphius-award for her master thesis around the use of HDAC6 inhibitors in Multiple Myeloma. This month, Eleni started her PhD in our @TNRR_Lab. Congrats and welcome (back) Eleni!

TNRR Team dinner after a day of scientific retreat 🤤

The limited predictive power of cell-based screening assays hampers the search for better glucocorticoids. In this latest research, we developed novel luciferase-based assays that are consistently better predictors for GC signaling on the endogenous level. sciencedirect.com/science/articl…

Congrats to our latest lab member Lisa Koorneef for obtaining the @FWOVlaanderen Junior Postdoc grant on battling Rheumatoid Arthritis with Nuclear Receptor Heterodimers. Good luck finding the best of both worlds!

New work of Laura of @TNRR_Lab and my lab: "Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets" biorxiv.org/content/10.110… with @Svennetti @AnStaes and many more!

Striving to improve treatment responses and quality of life of multiple myeloma patients by studying nuclear receptor crosstalk (Dorien Clarisse, @TNRR_Lab) #whywecare #dagtegenkanker

Our myeloma team participated to the Wear Red Day of @metoyoufonds .Let's raise awareness for blood cancer! #samensterk #stichtingmetoyou #fightbloodcancer #WearRedDay @crighent

In the latest Nature Communications, Dorien Clarisse and Karolien De Bosscher, discuss the contribution of the Glucocorticoid Receptor in therapy resistance in the treatment of solid cancers. nature.com/articles/s4146…

CMB is op zoek naar een enthousiaste (bio-)IT'er ter ondersteuning van onze IT-systemen. jobs.vib.be/j/32337/systee…

Welcoming another talented PhD student to the team! Milton Antwi recently obtained his @FWOVlaanderen grant to study PPARα-ERRα ligand combinations in treatment of non-alcoholic fatty liver disease. 🤞🤞 for a Covid-free 2021 to celebrate this with the team!

@KrisGevaert_VIB @VIB_CMB Talented PhD student found! Chloé Van Leene started this month on her PhD project titled: "A new tool to map proteome conformations in cells to reveal the structural plasticity of the glucocorticoid receptor". Welcome and good luck, Chloé!

Please help spreading! The @VIB_CMB De Bosscher lab and my lab are hiring a talented PhD student who fearlessly will take on the challenge of using conformational proteomics to study the glucorticoid receptor. More info: jobs.vib.be/j/28602/phd-po….

Check out the latest review of Dorien Clarisse (Postdoc @TNRR_Lab ) in BBA-Reviews on Cancer. We discuss the need to reevaluate the use of glucocorticoids in lymphoid malignancies and how a deep understanding of glucocorticoid responsiveness is required. sciencedirect.com/science/articl…

New perspective paper by our PhD student Laura about the quest for improved Glucocorticoid Receptor Ligands! frontiersin.org/articles/10.33…

Take a look at our latest review on nuclear receptor crosstalk in Nature Reviews Endocrinology. Glad to have collaborated with Eva Estébanez-Perpiñá & Luc Brunsveld! @NatureRevEndo @Eva46653369

We are recruiting a new PhD student! Do you want to help us find novel therapeutic strategies to treat non-alcoholic fatty liver disease? Then this might be the perfect opportunity for you! More info: ugent.be/en/work/vacanc…

So happy to receive an @FWOVlaanderen grant! I will be joining @TNRR_Lab with my research focusing on the glucocorticoid receptor.