Tom Elliot

Salmonella could be engineered to help fight bowel cancer after research found the bacteria stops the body's own immune cells attacking the disease. 🔗 Read more trib.al/uGiqsQU

We're hiring! 3year post-doc available in the lab on fungal adaptation to the host. Funded by @wellcometrust and working closely with @BECKS_182 team. Further details in link below, informal enquiries welcome! uk.indeed.com/m/viewjob?jk=e…

Very excited to share our latest work, out today in @ScienceMagazine, on the serendipitous finding that vitamin D ☀️ regulates the gut microbiome to promote cancer immunity🦠 science.org/doi/10.1126/sc… 🧵👇 @ReiseSousaLab @TheCrick

✨New preprint ✨ So pleased to share my first ever paper from @DrMicroMandroid’s lab at @IMIBirmingham. Here, we used multiplex imaging to show a correlation between H. pylori and invasion of gastric microbiota during gastric cancer development 🧫 doi.org/10.1101/2024.0…

@harriet_jg @DrMicroMandroid @IMIBirmingham Congrats Harriet your RNAscope looks amazing!

Paper publication day! Our latest work online now in @NatureComms on the role of microglia in cryptococcal meningitis. Turns out these cells help the fungus more than us. Short thread of the main findings. nature.com/articles/s4146…

Here we discuss fundamental mechanisms of negative feedback control of TCR signalling, signatures of repsonse to checkpoint blockade, and how combination therapy strategies may overcome acquired resistance. (2/2)

Our review is out now in Essays in Biochemistry. T-cell response to checkpoint blockade immunotherapies: from fundamental mechanisms to treatment signatures. doi.org/10.1042/EBC202… (1/2) @BendingLab @DavidLeckyBio

NEW PREPRINT from the MasLab 😄. Great collaboration with @BendingLab and @SarahDimeloeLab for #Tcell dynamics and #immunometabolism. A beautiful example of #hostmicrobe dualism. Take a 👀 🧵👇🏻 biorxiv.org/content/10.110…

@ScottPLand @FSampaziotis @britsocimm Congratulations!!!

I’m super excited to announce that I’m one of the awardees of the BSI Career Enhancing Grant!! This will allow me to delve into the world of 3D cell culture and #Organoids with the generous help of @FSampaziotis. Thank you so so much @britsocimm! What an end to the year!

Super excited to have my first poster at #bsi2022! I’m presenting my work on the role of Nr4a1 (Nur77) during T cell development and the control of thymic Treg niche size. Come say hi at poster #434😊

Looking forward to present at #BSI22 my poster 466 this afternoon and discuss how combination therapy of anti-Lag3 and anti-PD-L1 can increase TCR signalling duration.

Come check out my poster 432 at #BSI22 today. Talking about regulation of TCR signalling. Also interested in discussing post doc work (graduating in about a year)

Happy birthday to meeeeeeeeeee #BSI22

💥 A new tool to assess rapid changes in TCR & BCR signalling dynamics #InVivo @TomAshEmElliot & colleagues relay a new transgenic reporter of antigen receptor signalling that expresses Fluorescent Timer protein under the regulation of Nur77 👉bit.ly/3gCvX2U 1/

CC @MaslowskiLab @LozanSheriff @DavidLeckyBio @GillianMackie_ @LisaScarfe2 @SophieRouvray Thanks for work on this project!

Differences in sensitivity between the two systems could well be due to much higher number of Nr4a1 transcripts over Nr4a3 in activated T cells. Please reach out to @BendingLab if you are interested in using Tempo mice! 12/

Glad to see this out! Thanks for support of @BendingLab and co-authors. In lymphocytes, expression of Nr4a family genes is controlled by antigen receptor signalling - making them great biomarkers of antigen detection. 1/