tRNA at UCSC Lowe Lab

Our method book chapter is out. Learn how to find and annotate #tRNA-derived RNAs from small RNA or tRNA sequencing data using our lab's in-house tools step-by-step. Analyzing, visualizing, and annotating tRNA-derived RNAs using tRAX and tDRnamer sciencedirect.com/science/articl…

🎉New RNAcentral paper published in Nucleic Acids Research! Discover automated literature integration, new expert databases, gene-level entries grouping related transcripts, and more: doi.org/10.1093/nar/gk…

📢 Rfam 15.1 is here! ✨ 50 new RNA families including riboswitch candidates, plastid ncRNAs, snoRNAs, plant xrRNAs and more. 🧬 10 families updated with 3D structures 🖥️ Brand new interactive alignment viewer Take a look xfam.wordpress.com/2026/01/08/rfa… #RNA #Bioinformatics #RNAbiology

In a new paper published today, we report a liver-enriched but overlooked small RNA as a key regulator of cholesterol homeostasis. This small RNA, tsRNA-Glu-CTC, could be a potential new target for treating liver disease and cardiovascular disease👇 nature.com/articles/s4146…

TRMT5-mediated N1-methylguanosine tRNA modifications drive mitochondrial function and drug tolerance in AML via oxidative phosphorylation. Read the full article in Blood: ow.ly/yjnc50XrThr

Happy to share our new review 🦠: tRNA-modifying enzymes in bacterial stress adaptation royalsocietypublishing.org/doi/10.1098/rs…

🎉 RNAcentral Release 26 is here! This release introduces a significant structural change: gene-level entries for ncRNAs across 204 organisms. For the first time, you can explore RNA data at the gene level, not just individual sequences. 🧵👇

tRNA hydroxylation is an epitranscriptomic modulator of metabolic states affecting Pseudomonas aeruginosa pathogenicity, with TrhPO, from Haussler lab academic.oup.com/nar/article/53…

tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa 🦠👏High-throughput tRNA epitranscriptome profiling using mass spec on P. aeruginosa transposon insertion library and links with metabolic networks doi.org/10.1093/nar/gk…

@GuopingLi2 @ScienceMagazine @SaumyaDas_Lab @MGHanesthesia @mghcvrc Congratulations! It's great to be part of this collaboration!

Our @ScienceMagazine paper is out! Discovered how tRNA-derived small RNA (tsRNA/tDR) protects kidneys via RNA autophagy. science.org/doi/10.1126/sc… Huge thanks to @SaumyaDas_Lab and all our amazing collaborators! Excited for the therapeutic potential ahead! @MGHanesthesia @mghcvrc

🚨 @emblebi is hiring a Project Leader to shape the future of RNA resources! Lead RNAcentral & Rfam, collaborate with global experts, and drive innovation in RNA biology. Apply now: embl.wd103.myworkdayjobs.com/en-US/EMBL/job… 🚀 #RNA #Bioinformatics #Genomics #DataScience #LifeSciences #EMBL

RNase L cleaves most tRNAs in the anticodon loops into various tRNA-derived RNAs (tDRs) including 5'-tDRAla that shows a translation inhibitory effect. Some tRNAs are also cleaved in variable loops. bit.ly/3YTwlNq

journals.asm.org/doi/10.1128/mb… First big Tucker lab paper! Everyone in the lab made an appearance on the author list:) So proud and grateful for our collaborators and to the editors/reviewers for helping us improve the manuscript.

We are very excited about our latest work, which just came out @embojournal – embopress.org/doi/full/10.10…. The work @MCB_UJ was driven by Anna Biela and @TingYuLin1031 in collaboration with Janusz Bujnicki and his team @IIMCB_Poland…a short🧵

I’m happy to share our recent manuscript in which we are structurally and biochemically investigating 3'-5' tRNA splicing ligases, including a #cryoEM structure of the five-subunit D. rerio tRNA ligase complex. jbc.org/article/S0021-…

@HiteshTikariha trna.ucsc.edu/tRAX/ is up running now.

@UCSCtRNA trna.ucsc.edu/tRAX/ webpage error: The requested URL was not found on this server.

Our method book chapter is out. Learn how to find and annotate #tRNA-derived RNAs from small RNA or tRNA sequencing data using our lab's in-house tools step-by-step. Analyzing, visualizing, and annotating tRNA-derived RNAs using tRAX and tDRnamer sciencedirect.com/science/articl…

#NewPaper 🧬 A new review dives into the structural biology of tRNA modifying enzymes. Authored by our scientists led by @GlattSebastian highlighting how cryoEM & crystallography reveal mechanisms behind key modifications. Read here: shorturl.at/akpeB @JagiellonskiUni

Check out the new R2DT 2.0 paper and try it out r2dt.bio It is great to be part of this project.

Not all tRNA fragments (tDRs) are created equal. Here we share methods to differentiate: 1) bone fide tDRs and those produced by dissociation of nicked tRNAs, 2) nicked tRNAs / tDRs in extracellular vesicles vs outside. 1) sciencedirect.com/science/articl… 2) sciencedirect.com/science/articl…