Daniel Wacker

Our latest work: As it turns out different positive allosteric modulators bind to different sites at the mu opioid receptor. Find out more in our @biorxivpreprint. biorxiv.org/content/10.110…

A take on the current state of biased signaling in psychedelic action and psychedelic drug discovery by John McCorvy and I: Biased Signaling in Psychedelic Action | Annual Reviews - go.shr.lc/4lx1pLf

Job Alert! Open Postdoc position in membrane protein structural biology, molecular pharmacology @ drug discovery in New York. More info can be found here: wackerlab.com

Lessons from a Toad Psychedelic about the Role of different Serotonin Receptors in Psychedelic Physiology: nature.com/articles/s4158… Congrats to Audrey and @LankriDavidIL in this collab with @SamesLab and @ScottRusso published in @Nature

Typo on my end: The study was spearheaded by @NeuroStructure

Tetracyclic Antidepressants Activate Understudied Serotonin Receptors: science.org/doi/10.1126/sc… Congrats to @NeuroStruct, @Allyparp, and Audrey Warren for their study in @ScienceAdvances with help from @martafilizola, @NCCATinfo, and @GradSchoolSinai!

Asenapine as a potent TAAR1 agonist nature.com/articles/s4146… Congrats @NeuroStructure

Tetracyclic antidepressants potently activate serotonin receptors 5-HT1e and 5-HT1F, explaining some of their clinically observed effects. @NeuroStructure @martafilizola @biorxivpreprint @biorxiv_neursci biorxiv.org/content/10.110…

Also, here is our @biorxivpreprint on the structure and pharmacological properties of human TAAR1 biorxiv.org/content/10.110…

Also, the lab is looking for a Postdoc conducting the type of research described in the paper: CryoEM, membrane protein function and pharmacology, drug discovery.

Structural Studies and Drug Discovery of SLC4A1/AE1 with @SchlessingerLab published in @NatureSMB: nature.com/articles/s4159…

Thanks to first author @CapperMichael and collaborators including @SchlessingerLab, we report 7 structures, uptake and computational assays. Our mechanistic work complements the beautiful AE1-erythrocyte complex architecture reported by @OliBClarke. biorxiv.org/content/10.110…

Sharing our @bioRxivpreprint of “Substrate Binding and Inhibition of the Anion Exchanger 1 Transporter”, in which we reveal how AE1 binds and transports substrates, and how different drugs inhibit the transporter.

Peer-reviewed version of ⁦@filizolalab1⁩’s ‘Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation’ is now available on @biophysJ - ScienceDirect sciencedirect.com/science/articl…

EXCITING NEWS! Dr. Denise J. Cai receives prestigious @NIH Director’s New Innovator Award from the @NIH_CommonFund’s High-Risk, High-Reward Research program! A HUGE CONGRATULATIONS to @denisejcai on this great honor!🍾🎉🌟 PRESS RELEASE: ow.ly/tO5y50wycTn

I am currently looking for a motivated Postdoc to join our team to work on the structure and function of neurotransmitter receptors and transporters. Spread the word! More info on our lab webpage wackerlab.com

Graduate student position available in my lab for highly motivated student!

Online now at Cell: VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells zpr.io/gJjGU

Now someone give @JustinGEnglish a real job already!

Congratulations to my former colleague Justin English for his new paper in cell cell.com/cell/fulltext/…