Wei Cheng

New online! UK Biobank at 20 — a growing, global resource for dementia research dlvr.it/TS2X6D

I am thrilled to share that I’ll be joining the University of Notre Dame (@NotreDame) as an Assistant Professor of Psychology this July!☘️🧠 Please reach out if you're interested in joining my lab! More details to follow soon.

Proteomics reveals three molecular subtypes of Alzheimer's disease with distinct progression patterns alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

2/7 Using a large (n = 863), multimodal, multi-intervention clinical imaging dataset, we applied precision functional mapping and found that key subcortical nuclei in Parkinson’s disease—including the SN, STN, VIM/CM, GPi, GPe, and putamen—are preferentially linked to the SCAN.

Most blood proteomics analyses of human disease focus on a single disease endpoint missing assessment of specificity. This analysis of 8,262 individuals across 59 diseases offers an atlas of Olink proteomic signatures across the disease spectrum.

Mapping the plasma metabolome to human health and disease in 274,241 adults go.nature.com/4mmToc0

In this study, Chen et al. use UK Biobank data to reveal a dietary pattern associated with a lower risk of dementia, and validate this in additional cohorts. nature.com/articles/s4156…

Now online - - had great fun thinking about this with colleagues from Shanghai! nature.com/articles/s4422… "brain-based heterogeneity is not a static feature; it is more pronounced at the onset of the disorder but reduced over the long term"

Overall, another great paper from the Alkes group at @HarvardChanSPH. Here are some of the co-authors I could find on twitter: @BennyStrobes @GaspardKerner @JohnNDanesh @WeiFDU @xilin_jiang Link to pre-print: medrxiv.org/content/10.110…

Our new study with Fudan University: Adolescents who sleep longer perform better at cognitive tasks | University of Cambridge ⁦@WeiFDU⁩ cam.ac.uk/research/news/…

Towards individualized #precisionmedicine and prediction of risk and treatment responses #heartdisease @uk_biobank @NatureMedicine nature.com/articles/s4159…

Up to 85% of people living with #dementia may not receive post-diagnosis care alzint.org/news-events/ne… via @AlzDisInt #Alzheimers

In response to a recent Guardian article about why approved researchers in China can access our data, we've provided some additional information for our participants, including how we follow Government guidance on who can use UK Biobank. Please read: ow.ly/m4x050VAIzp

Interesting reads on genetics, omics, & precision medicine from this week👇 1⃣A distribution atlas of the human proteome There is constant influx and efflux of proteins between the plasma and surrounding organs and cells. Applying proteomics in 18 organs & 8 blood cell types and integrating it with existing RNA/protein atlases, this study maps the tissue/cell origin of each plasma protein! 👉A foundational resource for discovering specific circulating signatures of organ pathologies. 🔗cell.com/cell/fulltext/…

Metabolite signatures of chronological age, aging, survival, and longevity cell.com/cell-reports/f…

Our April issue is now live! nature.com/neuro/volumes/…

👉Using data from the UK Biobank, the authors investigate the differences between short and long #sleep duration regarding genetics, biomarkers and phenotypic implications. ⁦@Jianfengfenguk, @WeiFDU nature.com/articles/s4422…

Finally, our winner for the 2025 George W. Snedecor Award is Hongtu Zhu! 🎉🎉🎉

Divergent biological pathways linking short and long sleep durations to mental and physical health | Nature Mental Health ⁦@Jianfengfenguk⁩ ⁦@WeiFDU⁩ ⁦@psychiatry_ucam⁩ ⁦@Nature⁩ nature.com/articles/s4422…

How do you get to the nitty-gritty of Parkinson's disease? Do high-throughput proteomics. nature.com/articles/s4358…