allardlab

Brady's work is published this week in Biophysical Journal! Mathematical link between cell mechanics and percolation theory cell.com/biophysj/fullt…

Review article with Omer Dushek @Dushek on tethered signaling proteins, out now! Tethered bio-molecular reactions can do at least 7 cool things that freely-diffusing reactions do not. Read more here! #IDR #TCells #cytoskeleton annualreviews.org/content/journa…

Many reactions in cells are tethered, often by #IDR. If 2 tethers are tied together (imagine handcuffed arms ⛓️‍), does this enhance or suppress their reactions? Formin, one of the major #cytoskeleton builders in eukaryotes, does exactly this.

Katie Bogue's new preprint with Margot Quinlan and Bryan Christian, out now! biorxiv.org/content/10.110…

A remarkably simple question, "What is the likelihood landscape for the basic bursting transcription model?", reveals surprisingly complex underlying structure, with implications for the limits of what single-cell data can tell you.

Very excited to be involved in this new work led by Junhao Gu and Elizabeth Read, out this week in Bioinformatics. Collaboration with @timothy_lamont, @ChrisEMiles and others! academic.oup.com/bioinformatics…

We can make the flexibility of a model match the hypothesis being tested -- more flexibility is not always better, if it prohibits rejection of the hypothesis. Here is one simple case involving T cells where it made a difference! biorxiv.org/content/10.110…

Our paper with with @timothy_lamont and @ASpakowitz is out in Nucleic Acids Research! academic.oup.com/nar/article/53…

Brady's preprint on astral cytoskeletal structures is on biorxiv! A surprising connection between percolation and asters, and another example where an optimal choice aligns with the cell! biorxiv.org/content/10.110…

Polymer mechanics modeling, ATACseq, EM, 4C-seq working together to explain 3d genome organization. The most surprising thing to me is the continuing high predictive power of models fairly few, fairly simple biophysical factors.

Small changes in nucleosome placement -- even at approximately the same average frequency, even ~100kbp from the loci -- can drive contacts between TF binding motifs and gene promoters.

Jack's preprint with @timothy_lamont and @ASpakowitz is out on biorxiv! biorxiv.org/content/10.110…

Group dinner, including our colleague Jin Yu, some alumni, and two years' worth of amazing @UCI_CMCF high school researchers!

We generate a song for every group meeting now.

We are very pleased to announce that our colleagues @allardlab have kindly produced a fantastic summary of our EMBO Journal manuscript in the form of AI-generated Korean Pop! @embojournal embopress.org/doi/full/10.10…

Lab dinner

Attention biomechanics & mechanobiology folks! We are super-excited to announce that we will be hosting the next MechBio Symposium @CUBoulder @BioFrontiers on April 6-7, 2024! Please visit tinyurl.com/cumechbio24, save the date, and fill a short information form. RT+amplify 1/N

UCI crew

Allard Lab at #BPS2023 !

If you know anyone interested, and they have any questions, feel free to DM me or @mcsb_uci