Caroline Watson

📢Clonal hematopoiesis driven by mCAs📢What fitness effects do mCAs confer to our blood cells?🩸 How often do they occur? Does an mCA’s fitness correlate with blood cancer risk?🔎Read mine & @jrblundell's latest paper @NatureGenet to find out (& more!):👉🔗rdcu.be/dlRRr

In 1999, Tom Maniatis discovered something remarkable: neurons achieve self-avoidance via stochastic methylation of the protocadherin gene cluster. We've just discovered this locus is an evolvable in-vivo barcode across the human tissues: biorxiv.org/cgi/content/sh… 🧵

What a remarkable essay about the poignancy and marathon of a rare, high-risk acute myeloid leukemia diagnosis in a young person (Tatiana Schlossberg). So moving. 🩸🎗️💔 @ASH_hematology @SylvesterCancer @ASCO

🧵Just out in Blood @BloodPortfolio: Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy ashpublications.org/blood/article-… We study how resistance and durable remission emerge in IDH1-mutant AML.

If blood has clonal haematopoiesis… sperm should get clonal spermatopoiesis, right? 😉 Two great @Nature papers shed new light on how mutations drive clonal selection in sperm stem cells: 🧬 Neville et al. 👉 nature.com/articles/s4158… 👨‍👩‍👦 Seplyarskiy et al. 👉 nature.com/articles/s4158… I had the privilege of writing the accompanying News & Views: 📝 rdcu.be/eL976 (Image © Nature)

Leukocytes are present in pretty much all our body fluids (and solids). Ever wonder whether you can detect clonal hematopoiesis in body fluids beyond blood? Short answer is yes and at a VAF surprisingly similar to blood. Cool work from the MSKCC CH clinic! jci.org/articles/view/…

🚨📢❗So proud and excited to share our latest work, "Clonal Hematopoiesis Dynamics and Evolutionary Fitness During Cancer Treatment Impact Clinical Outcomes", now available: medrxiv.org/content/10.110…🧵

Biobank scale #CHIP calls are a great first pass... but to establish the true strength of disease associations we need to use deep targeted sequencing.

Highly accurate sequencing OR high throughput? We refuse to choose. Introducing paired plus-minus sequencing (ppmSeq), a method built to deliver both. Our latest paper with @UltimaGenomics 👀👀👀 See ⬇️ for a primer on the next frontier of genomics biorxiv.org/content/10.110…

Germline genetic variation has been linked to both hematologic cancer and clonal hematopoiesis. But does germline variation influence the likelihood of CH progressing to cancer? And if so, why? We tackle these questions here in @NatureGenet nature.com/articles/s4158…

The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to disease? These and other questions we will tackle within the SMaHT Network, now described in @Nature nature.com/articles/s4158…

Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx. By brilliant @__AFonseca ✅Early cancer ✅Methylation drivers ✅Epimutation rates ✅CpG lineage tracing biorxiv.org/content/10.110…

EVIDENCE OF SOMATIC EVOLUTION IN tRNA genes!!!! This finding could revolutionize what we know about cancer and somatic evolution in aging. Coming from the wizard of tRNA himself, Lluis Ribas, and genomeologist extraordinaire Fran Supek! biorxiv.org/content/10.110…

🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in @NatureGenet 🧬! shorturl.at/94s5S We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n 🧵👇

@CKBrierley @NatureGenet @ArbachHratch Congrats Charlotte! 🤩🤓

Excited to share with all our latest work on the use of single cell tools in following IDH mutant AML patients during their treatment! Out today @CellStemCell !! An amazing collaboration with @AkEisfeld & @PapaemmanuilLab & @landau_lab !!! Driven by the impressive @MariaSirenko and @soobeomlee & Zhengxi Sun at @NYUGSOM_Path

Thrilled to share our latest research out today in @Nature: “Microbial metabolite drives ageing-related clonal hematopoiesis via ALPK1” nature.com/articles/s4158…

The potency of abnormal genetic fusion in chronic myeloid leukaemia in our latest study @Nature 👉🏽 nature.com/articles/s4158… This cancer is an oddity - one of the few single genetic “hit” cancers, a short trajectory (few years) from start to diagnosis, and explosive growth.

🚨🚨 Our new manuscript is now available online! Co-led with the awesome @mingxiangteng Peripheral blood somatic mosaicism and clonal hematopoiesis across ancestry backgrounds medrxiv.org/content/10.110…

The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our Nature paper: nature.com/articles/s4158…

Delighted to share a major update on our work investigating age-related deceleration in clonal haematopoiesis. Takehome: Widespread and substantial deceleration in fitness with age! Amazing effort by PhD student @hamish_macg 💪 biorxiv.org/content/10.110…