डा. बिशाल ढकाल

Sometimes we start our journey because we wish to reach the destination, Where as destination is an assumption and imagination and journey is always a reality. Learning to be in the journey everyday. Thank You !! #mastersofscalesummit

MESSAGE I wholeheartedly endorse the powerful appeal for peace made by the Holy Father, Pope Leo, during his Palm Sunday Mass. His call for the laying down of arms and the renunciation of violence resonated profoundly with me, as it speaks to the very essence of what all major religions teach. Indeed, whether we look to Christianity, Buddhism, Islam, Hinduism, Judaism or any of the world's great spiritual traditions, the message is fundamentally the same: love, compassion, tolerance, and self-discipline. Violence finds no true home in any of these teachings. History has shown us time and again that violence only begets more violence and is never a lasting foundation for peace. An enduring resolution to conflict, including the ones we see in the Middle East or between Russia and Ukraine, must be rooted in dialogue, diplomacy and mutual respect — approached with the understanding that, at the deepest level, we are all brothers and sisters. I urge for and pray that the violence and conflicts may soon come to an end. DALAI LAMA 31 March 2026

Latest business idea for startups! 😀😛😂 #gascylinershortage

प्रोफेसर हुँ भनेर दुनियाँको दिमाग भुटीराखेको China मा बस्ने Chinese मुलको यो Canedian को धोती खुस्काईदिएछ साथीले !😂😂

Workers building a suspension bridge in Nepal at extreme height in dense fog.

Carved from a single massive basalt rock, the Kailasa Temple at Ellora is the world’s largest monolithic rock-cut structure. It was created in the VIII century

A high tech US factory turns banana leaves into organic fertilizer pellets using automated systems, and studies show this natural solution can boost rice yields by 20 to 30 percent while reducing chemical fertilizer use 🌱

Neighbours first: @the_hindu Editorial On India-Nepal ties after the swearing in of new PM Balen Shah thehindu.com/opinion/editor…

AIIMS New Delhi congratulates its alumna Ms. Nisha Mehta (BSc Nursing 2006–2010) on her appointment as Health Minister of Nepal. Her achievement is a proud moment for the entire AIIMS community, especially the nursing fraternity. We wish her success in her new role.

China has issued the world's first prescription for Libevitug, a groundbreaking monoclonal antibody drug for the treatment of hepatitis D virus, at a Beijing hospital, marking a milestone in global viral hepatitis care. The China-developed drug works by blocking hepatitis B and D viruses from entering liver cells. Clinical results demonstrated significant efficacy in virological response and normalization of liver function, with particularly notable benefits for patients with cirrhosis. It is the first monoclonal antibody ever approved for viral hepatitis worldwide, filling a long-standing treatment gap for one of the most severe forms of the disease.

सबैलाई शुभ बिहानी 🙏🙏 आज म खुसीको कुरा शेयर गर्दै छु । जेनजी आन्दोलनको क्रममा जलाइएको हाम्रो Gallery by Himalayan Java बत्तिसपुतली करीब सात महिना पछी पूर्ण रूपमा सञ्चालनमा आएको कुरा यहाँहरूलाई जानकारी गराउन चाहन्छु । ।

CRISPR deleted the extra chromosome behind Down syndrome. In a groundbreaking world-first, researchers have successfully used CRISPR gene-editing technology to remove the extra chromosome responsible for Down syndrome, opening a potential path toward treating genetic disorders previously considered incurable. Down syndrome, or trisomy 21, occurs when a person has three copies of chromosome 21 instead of the usual two. It is one of the most common genetic conditions, affecting about 1 in 700 babies worldwide, and leads to intellectual disability, developmental delays, and various health issues. Until now, no treatment has been able to correct the underlying cause. That may soon change. In a new proof-of-concept study, scientists applied CRISPR-Cas9 to cells taken from people with Down syndrome—including skin cells and pluripotent stem cells—and successfully eliminated the extra chromosome 21. The edited cells showed a striking return to normal gene expression patterns and cellular function. To improve precision, the team briefly disabled certain DNA-repair pathways during the process, making the chromosome removal cleaner and more effective. At this stage, the technique has only been demonstrated in laboratory cell cultures and is far from ready for human use. Removing an entire chromosome carries significant risks, including possible off-target effects, so extensive safety work lies ahead. If those challenges can be overcome, however, the approach could one day be applied to brain cells or even used during early fetal development. The implications extend beyond Down syndrome. The same strategy might eventually treat other life-limiting trisomies, such as trisomy 13 and trisomy 18, which are often fatal in infancy or cause severe disability. For the first time, a tool exists that could, in principle, correct the root chromosomal abnormality rather than merely managing symptoms. ["Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells." PNAS Nexus, 2025]

Educated and employed but still struggling: India's middle class under strain bbc.in/41yZTk3

Why you can’t sleep without a blanket, even when it’s hot

A scarecrow made of balloons

«Be kind. Always»

मेरो राजनीतिक विचार फरक हुन सक्छ तर नागरिक भई आफ्नो देशको सरकारको सफलताप्रति प्रतिबद्ध छु। सरकार स्थिर रहोस् भन्ने सकारात्मक वातावरण सिर्जना गर्नु पर्छ। सबैले यो सरकारको सफल कार्यकालका लागि साथ र सहयोग गरौँ। सरकार सबै नेपालीहरूको साझा चौतारी हो - हाम्रो नेपाल, राम्रो नेपाल 🙏🏼

Heart disease

A proton therapy machine rotating around a patient for cancer treatment. Proton therapy revolutionizes cancer treatment with proton beams that stop precisely at the tumor.

Bypass surgery is a life-saving procedure used to restore blood flow to the heart when coronary arteries are blocked or narrowed. [🎞️ otknowledge1]

Great decision.