Jack Bateman

Single cells can learn without a nervous system, but how? In our new preprint, Deepa Rajan and I describe a simple model for habituation in Stentor cells, based on mechanoreceptor internalization and recycling, and test it with quantitative experiments. biorxiv.org/content/10.110…

Our newest paper is out today in PNAS! Small-molecule disruption of androgen receptor–dependent chromatin clusters pnas.org/doi/10.1073/pn…

🚨Inter-chromosomal contacts (‘kissing chromosomes’) organize human genome topology along a spatial gradient of genome activity (62 Hi-C datasets). Check rdcu.be/dZYQw, @NatureComms, @4DNucleome, @The3DGenome, @humangenomeorg, @netscisociety, @Emblebi, @MoGen_Grads

Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade #Fa" target="_blank" rel="nofollow noopener">science.org/doi/10.1126/sc…

Now Online: Transcription regulation by biomolecular condensates go.nature.com/3OkCn41

Structural duality enables a single protein to act as a toxin–antidote pair for meiotic drive | PNAS pnas.org/doi/abs/10.107… & A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring | PNAS pnas.org/doi/abs/10.107… 2 amazing papers! 🤩

A lab handbook can help with the day-to-day challenges of running a lab and promote a positive culture. Check out these in-depth resources, including a template, to help you write your own. 3/n elifesciences.org/articles/88853…

Check out our latest review on how cooperativity influences transcriptional bursting. Kudos to the first author Charis Fountas! sciencedirect.com/science/articl…

dehydrated tardigrade coming back to life after water being poured over it

I have written a concise review on chromatin transcription as part of the @JMolBiol special issue on transcription elongation. Check it out! authors.elsevier.com/sd/article/S00…

How are promoter interactions coordinated during cell differentiation? In our first paper, we investigate the temporal relationship between genome folding, transcription and histone modifications during ESC differentiation. (1)

New preprint by @jzhao111, Nick Lammers, @yangjoonkim and Simon Alamos! Combining optogenetics, live imaging and theoretical modeling to biochemically dissect repressor action in living animals. biorxiv.org/content/10.110…

Timescales in Cell Biology

Emerging links between phase separation and transcription factor haploinsufficiency: Trends in Genetics www-cell-com.insb.bib.cnrs.fr/trends/genetic… by the one and only Reiner Veitia

Born in Jamaica to an enslaved mother in 1799, John Russwurm attended Bowdoin College & studied the Haitian Revolution. After graduation, he & Samuel Cornish founded the anti-slavery newspaper Freedom’s Journal in 1827. The paper had a national & international readership.

1/n) Excited to share our new preprint: Using high-res live embryo imaging we show that transcription factor hubs are localized to new genes when specific DNA binding is perturbed. Hub interaction kinetics at these new sites determine factor occupancy: biorxiv.org/content/10.110…

Online Now: Transcription dynamics and genome organization in the mammalian nucleus: Recent advances dlvr.it/TFMk27

Latest preprint on transplanting chromosomes into microfluidic biochips and rebooting the genome with cell-free gene expression. The deconstruction into a simple artificial system revealed fascinating DNA swelling dynamics with transcription. Enjoy! biorxiv.org/content/10.110…

@JullienFlynn Love it! How do you get them out? Any trouble with food slipping out when you do?

My flies are doing quite well living in reusable glass mason jars and reusable glass vials. My lab is producing almost no plastic waste, spending $20 a month on fly food, and only 3-4 hours a week making the food and washing the vials. #newflylab #proudPI #EcoFriendly

Cost of having DNA methylation: DNA replication by DNA polymerase epsilon is a source of C to T mutations in CpGs, especially methylated ones. This expands our understanding of one of the most widespread endogenous mutational mechanisms. nature.com/articles/s4158…