Adi

I have joined Bluesky and I will be posting regularly on Bluesky, instead of X. Follow me on Bluesky bsky.app/profile/aditya…

Excited to share our review where we propose models for how DNA secondary structures destabilise the replication fork and lead to ssDNA gaps — it’s comprehensive but genuinely a thought-provoking piece. Hope it’s useful to the community. sciencedirect.com/science/articl…

Thrilled to share our latest work in @Nature! We show how cancer cells navigate DNA replication despite DNA damage, revealing new insights into genome stability. Huge thanks to my incredible collaborators! Check it out here: nature.com/articles/s4158…

I'm diving into machine learning for biology! I have some coding experience but no ML background, and my first milestone is getting up to speed with #AlphaFold2. Any tips or resources on where to begin?

"Your work demonstrates to scientists, politicians and university administrators how important it is that scientists are given the freedom to pursue promising lines of research without having to worry about their immediate practical applications" Such an important statement

A new study finds ants best humans at tests of collective intelligence. Learn more: scim.ag/41ZVpVc @NewsfromScience

I wrote up some notes on visualizing proteins in David Goodsell's cartoon-ish style using PyMOL (or ChatGPT, or other software.)

Only the unimaginative limit themselves to hypotheses when analyzing a new dataset. A thread on exploratory data analysis ⬇️

So excited that our work on predicting gene expression from histone modifications using deep learning is out in @NAR_Open today. Brilliant to work with lead author @Al_Murphy_ and collaborators Aydan Askarova, @BorisLenhard and @n_skene 🧬⭐️🙏 academic.oup.com/nar/advance-ar…

Check out our recent work uncovering an unexpected role of the replicative helicase CMG in influencing cell fate decisions in vivo! We also showed that it promotes differential expression of the highly conserved cell death gene egl-1 in cells fated to die!

This work was done at @uclcdb and other collaborators in Germany! @UCLResearch @uclbiosciences

Check out the press release I wrote about our latest work on cell fate decisions in vivo! Our study has revealed that the highly conserved replicative helicase CMG promotes apoptotic fate & others such as neuronal or glial cell fate #ResearchHighlights ucl.ac.uk/biosciences/ne…

“Writing = thinking” .

A friend asked me to explain DNA, RNA, and epigenetics. he said that others had tried before, but it didn’t click for him. I happen to play the piano, so I gave him a simple, albeit imperfect, analogy. After this analogy, he finally understood! Here’s the piano analogy. 🧵

Our study on how the human MCM2-7 helicase is loaded onto replication origins 🧬 is now online @Nature! 🎉 Our findings reveal that unlike in yeast, human MCM loading does not require ORC6 and can occur through multiple pathways. Read more here: rdcu.be/d1F6S

Online Now: Acute multi-level response to defective de novo chromatin assembly in S-phase dlvr.it/TG85ld

SpotMAX, our software tool for analysing multi-dimensional microscopy data, is finally out! 🎉 And conveniently, I just presented it at the #I2K conference 😀 A multi-year-long effort of many great collaborators and users. But what can SpotMAX do? A small thread

Thrilled to share our new work @biorxivpreprint: biorxiv.org/content/10.110… Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live cells. We reveal genome chromatin is essentially replicated from regions with greater nucleosome motions. 1/2

Wonderful news! Parafilm M rules! Very well-deserved recognition after helping so many other #NobelPrize winners achieve their breakthroughs! Congratulations @ParafilmM

This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans. Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals, making it a useful model for investigating how tissues develop and mature in multicellular organisms. Read how the 2024 medicine laureates’ investigations into C. elegans revealed an entirely new dimension to gene regulation: bit.ly/4dlPE6f #NobelPrize