Alex Banks

Thank you to the thousands of CalR users for all the positive feedback. We are happy that your in vivo energy balance analyses just got faster and easier. We secretly made this tool to solve our own problems. Looks like it helped others too.

So proud of wife and partner @SarahFlierMD and all of her accomplishments being recognized tonight by the crohns and colitis foundation @CrohnsColitisFn this evening.

@Maratosflier @EricTopol @Nature They do measure metabolic rate and report binned and adjusted energy expenditure in Extended Data Fig. 2. It's hard to tell if torpor is happening, and they don't mention it. In all fairness, they present a ton of data in a strict word limit.

@EricTopol @Nature Whike a comprehensive mouse study be nevertheless about genetically diverse mice not humans. Findings confirm & somewhat extend what's known about inbred mice. Point to note: 2 days consecutive fasting usually leads to mouse torpor. @Bankslab Was this evaluated?

New @Nature The largest study of impact of dietary restriction (DR) in ~1,000 mice with diverse genetic background for health and lifespan nature.com/articles/s4158… —40% caloric restriction had the most lifespan expansion effect but suppressed immune response and loss of lean muscle mass —a divergence of health and longevity effects of DR —"genetic background proved to be the more important factor in determining lifespan."

Say good morning to our new medicine laureate 🎉 Gary Ruvkun was woken up in the early hours to the news he had been awarded the 2024 Nobel Prize in Physiology or Medicine. Stay tuned for our interview with him, coming soon.

This is Canadian chic. Too cool for me. But Lawrence also knows how to rock the whole-body tyvek suit and hair bonnet--Boston style.

The Yale MMPC-Live is delighted to offer an opportunity for free metabolism focused, preclinical grant reviews to New Investigators from historically marginalized backgrounds and at predominantly minority serving institutions (1/🧵)

@HaopengXiao @StanfordBiochem @StanfordCancer Congrats HP!

Excited to share that the Xiao lab is launching at @StanfordBiochem and @StanfordCancer this fall! We will be soon seeking a research technician and a postdoctoral fellow. If you are interested, feel free to email me and I'd be happy to chat! More info: xiaolab.space

Imagine winning a gold medal at the Olympics then next week you’re on rounds with a nephrologist answering questions about free water deficit

How ridiculous that legacy metabolic phenotyping companies still normalize EE data by body mass! This approach has been discredited for many years & has polluted the biomedical literature for decades. Normalizing EE by body mass raised to the 0.75 power is even more absurd; an abuse of Kleiber's INTERspecific (NOT intraspecific) mass scaling exponent. For more details, see my definitive textbook on metabolic measurement, "Measuring metabolic rates: a manual for scientists", published by Oxford University Press. The best state of the art analytical routines for extracted data can be found in @Bankslab's CalR.app.

Can't wait to read the methods section on this one.....

Tuna has an incredible capacity for mitochondrial OXPHOS in muscle. How do we study it? This is our way -- thanks to Luke Mead and Ray. Just to add, the samples are incredibly tasty.

His humor, scientific insights, and mentorship will be sorely missed. His support altered the trajectory of my career and that of many others. He was just so good. My thoughts go out to his family and everyone close to Dave.

@SarahDeemerPhD Happy to help.

Hello friends! Have any of you used CalR for analysis of EE data? I have some CLAMS data I want to run, but I am a bit confused on the first step of setting up the data file to import into CalR. Thank you in advance for any help/insight!

100% yes. Shout it from the rooftops.

@DanielJDrucker @MolMetab Very cool

A new mode of action of sulfonylureas is proposed which is mediated via their interference with PPARγ phosphorylation rather than via classical PPARγ agonist activity at clinical concentrations @MolMetab sciencedirect.com/science/articl…

This is an exceptional opportunity for post-bacs interested in metabolism and metabolic disease. Research experience in Joslin-BIDMC/Harvard with stipend and benefits. Please apply or spread the word!! joslin.org/research/learn…

@bmp_forum I'll be there and may ask-a-lot-l questions

We promise there will be axolotls ☺️! (Image credit: Paul Starosta via Getty Images).

@realTonyHui This looks like a powerful new method. Can't wait to dig in.

Happy to share a preprint on our effort of building whole-body flux models. We integrated the key organismal metabolic parameter CO2 production rate and also its isotope labeling into the in vivo isotope tracing framework.

@DanaHut57968913 Right now it only combines 2 runs at a time but can be run multiple times. calrapp.org/templates/CalR…

hey indirect #calorimetry users! We've launched a new version of CalR to analyze your data. Test the beta version at CalRapp.org. New features: improved visualizations, quality control analysis, statistical power, energy balance, and more. Free! Feedback wanted pls.

@FuegerLab Sorry! Send us the files and we'll diagnose the problem

@Bankslab We keep getting a “disconnected from the server. Reload” message. Thoughts?