Differentiation Journal

Differentiation is the flagship journal of the International Society of Differentiation (ISD) @intlsocdiff. We are a multidisciplinary journal focusing on principal subject areas of cell and tissue differentiation, embryonic development, cellular structure and function, and 1/4

Jessica Cristina Marín-Llera et al. explored the role of CEK8 (Ephrin-A4) in early tendon differentiation in the chicken limb and its interaction with WNT/β-catenin and TGF-β pathways during tendon blastema formation. Learn more: doi.org/10.1016/j.diff…

“Development and proteome characterization of a new muscle cell line from Oreochromis niloticus (Linnaeus, 1758),” by Vijay Lakshmi Sahoo et al. Learn more: doi.org/10.1016/j.diff…

Deadline extended: Submit your research on splicing in development and disease to the Differentiation special issue led by Guest Editors Natoya Peart and Karine Choquet by June 30, 2026. Learn more: sciencedirect.com/special-issue/…

Findings from Chuanqing Mao et al. suggest that vismodegib disrupts TMJ development by inhibiting the Ihh-PTHrP signaling pathway, thereby altering angiogenesis in the condyle and ultimately impairing cartilage growth and structural integrity. Learn more: doi.org/10.1016/j.diff…

“Odd-skipped family members have conserved roles in segmentation, appendage, excretory system and gut development in bilaterian animals,” by Vasikar Murugapoopathy et al. Read the open access Perspectives article in Differentiation: doi.org/10.1016/j.diff…

Review article: Siti Nurnasihah Md Hashim et al. explored how chemical and mechanical microenvironments cooperate to guide epithelial commitment across both conventional 2D and advanced 3D culture models. Learn more: doi.org/10.1016/j.diff…

Review: “Gut and oral microbiota in oral bone tissue engineering: Impact of mechanistic and molecular pathways,” by Khushi Gupta, Jiyaur Rahaman, and Dhrubojyoti Mukherjee. Learn more: doi.org/10.1016/j.diff…

Wantong Zhang et al. highlight small nucleolar RNA host gene 6 as a key regulator of human dental pulp stem cells differentiation through PI3K/Akt/mTOR signaling, offering new insights into the molecular mechanisms that control odontoblast formation: doi.org/10.1016/j.diff…

Mahtab Mottaghi et al. review key biological properties of dental pulp stem cells that govern the production and function of their exosomes, which underscore their potential applications in successful therapeutic approaches: doi.org/10.1016/j.diff…

As part of a larger effort to sequence patients with micrognathia and cleft palate, Andrew M. Vontell et al. identified candidate pathogenic variants in dmx-like 1 (DMXL1). Read the open access article in Differentiation to learn more: doi.org/10.1016/j.diff… @Paul_Iyyanar

Grateful for the @Diff_Journal community in 2025! Thank you to everyone who submitted, reviewed, edited, and attended our @intlsocdiff Differentiation Across Scales Virtual Seminars. We welcome new submissions, support no-cost pub options, and encourage preprints. On to 2026!

New to Differentiation: Explore the curated collection of 11 articles highlighting the latest key advancements and discoveries in osteo biology—from 2023 to present: sciencedirect.com/special-issue/…

Parth Aphale, Himanshu Shekhar, and Shashank Dokania provide a critical appraisal of “Osteocyte-like differentiation of osteosarcoma by inorganic phosphate,” by Suzuki et al. (Differentiation, 2025, 146:100912). Read the letter to the editor to learn more: doi.org/10.1016/j.diff…

Deadline approaching: Submit to the forthcoming Differentiation special issue, “Splicing in Development and Disease,” by December 30, 2025! Learn more about the scope, guest editors, and benefits of publishing in a special issue: sciencedirect.com/special-issue/…

“fam20b-dependent proteoglycans do not affect dermal bone formation and fin regeneration, but Bmp signalling promotes fin regenerate outgrowth,” by Elham Koosha et al. Read the open access article to learn more: doi.org/10.1016/j.diff… @EamesLab

Thank you, everyone, who joined the latest “Biological Differentiation Across the Scales” virtual seminar last week with @pavi_dilsh from Misty Riddle’s lab @unevadareno. Couldn’t attend the live seminar? The recording is now available online! Watch now: isdifferentiation.org/Journal/Pages/…

TOMORROW: Join the Editors-in-Chief of Differentiation at 12:00 p.m. Central for a free virtual seminar with @pavi_dilsh. Registration closes 30 minutes before the event: my.isdifferentiation.org/ISD/Events/Eve… Article: doi.org/10.1016/j.diff…

Please join us on Friday November 14th for: Differentiation Across Scales, "Enteric neural crest development in Astyanax mexicanus surface fish and cavefish.” Our presenter will be Pavani Ponnimbaduge Perera from Misty Riddle’s lab @unevadareno. It’s free to register!

Mirco Galiè summarizes studies supporting the hypothesis that the partially or fully mesenchymal phenotype represents a general paradigm of stem cell plasticity underlying embryonic development, regenerative potential, and their pathological counterparts: doi.org/10.1016/j.diff…

One week left to register! Join the Editors-in-Chief of Differentiation on November 14 at 12:00 p.m. Central for a free virtual seminar with @pavi_dilsh on the enteric nervous system, evolution, and cave fish. Register: my.isdifferentiation.org/ISD/Events/Eve… Topic: doi.org/10.1016/j.diff…