Han de Winde @handewinde.bsky.social

This is why we work on #Biotechnology #GreenChemistry #Biobased_solutions with curiosity-driven and application-inspired research on several microorganisms. @IPCC_CH special report #ClimateChange is reason enough - if not, read: scientificamerican.com/article/the-wi… and reut.rs/2Y0HSLp

Just like this ... cycling to work ... beautyful springtime, makes you wonder, why all the fuss ?....

Glad to present this creative study by @Qing_Zhou revealing #Glutathione_Peroxidase in #Pseudomonas as secreted #Versatile_Peroxidase maintaining redox balance during #lignin-derived metabolism. Further step in natural polymer valorization. @LeidenBiology doi.org/10.1016/j.nbt.…

🔬 𝐖𝐡𝐨 𝐬𝐡𝐨𝐮𝐥𝐝 𝐚𝐭𝐭𝐞𝐧𝐝 #𝐄𝐂𝐁𝟐𝟎𝟐𝟔? 🌍 ECB2026 connects academia, industry and emerging talent to turn biotechnology into solutions for global challenges. 🎓 Academia & Research 🏭 Industry & Innovation 🚀 Early-Career Researchers 📍 Antwerp | Shaping tomorrow: #Biotechnology for Health, Food, #Energy and #Environment Register now: ecb2026.com #Sustainability #EFB #Biomaterials #Pharma #Callforabstracts #LifeScience #Microbiology #Conference #GreenBiotech

@GillesvanWezel @JoVerschoor Indeed a true piece of art, in several ways !! 🍀👏😄

today I received the amazing PhD thesis of @JoVerschoor aupervised by @HandeWinde. Congratulations for this great piece of work!

Highly interesting and enthusiasmic contribution by Tilman Weber @VIBTrainConf #Microbes25 on latest developments in innovative computational discovery, molecular characterisation and harnessing of novel #antibiotics of bacterial origin #AMR

Kick off of @vibtrainconf #Microbes25 by Kevin Verstrepen @verstrepenlab Looking forward to another exciting edition of innovative microbe research, and meeting up with friends and colleagues

Autumn ?? ...

Glad to present our identification of novel #polyester-degrading #Fusarium #cutinases and heterologous functional expression in #Aspergillus. Another piece of tenacious work by @JoVerschoor and several fantastic colleagues @LeidenBiology @ASMicrobiology journals.asm.org/doi/10.1128/sp…

There is a yellow worm, called Paralvinella hessleri, that lives near hydrothermal vents in the deep ocean. Its body weight is about 1% arsenic by mass; a ridiculous concentration. But instead of killing the worm, the worm “neutralizes” it and turns it into a yellow pigment. Inside the worm’s epithelial cells, arsenic is shuttled into vacuoles by protein transporters. At the same time, hydrogen sulfide (also abundant near hydrothermal vents) diffuses into the cells and binds to intracellular hemoglobin proteins, which carry it into the vacuoles. There, in the vacuoles, these two toxins react to form orpiment (As₂S₃), a bright, yellow mineral. The orpiment molecules form huge crystals; about 0.8–1.3 μm in diameter, or the size of an E. coli cell. Orpiment was used to make yellow paint during the Middle Ages and Renaissance. The Italian painter Cennino Cennini, in Florence, wrote about grinding up orpiment to make his yellow paints -- which was super toxic! When I first read through this paper, I wondered why the worms are bringing in arsenic in the first place. Why not just exclude it from entering into cells? Well, it seems like arsenic sneaks into cells through phosphate transporters, because they look similar, and evolution hasn’t found a way to exclude one but not the other. This also happens in plants, and it's known as "adventitious uptake." Poison sneaks into the organism through a protein that is required for survival! Organisms need phosphate to build DNA, make energy molecules, and so on. Finally, the authors did a proteomics experiment to figure out which proteins are expressed in these worms. They found 2,379 different proteins in the yellow granules, including a membrane protein that is evolutionarily similar to the Multidrug Resistant-associated Proteins found in microbes. (Microbes use those proteins to pump out antibiotics, for example.) It seems the worms adapted this protein to sit on each vacuoles' membrane and pump arsenic into them. They basically evolved a way to neutralize a poison with a poison.

1/ 🚨 New preprint! We've developed a robust IDMS-based LC-MS/MS workflow for high-throughput intracellular metabolomics in diverse bacteria. biorxiv.org/content/10.110… #Metabolomics #MassSpec #SystemsBiology

Incredibly sad news. Huge loss for family, friends and colleagues ... universiteitleiden.nl/en/news/2025/0…

🇫🇷 #TDF2025 Yesterday, just before the summit of the Tourmalet, Julian Alaphilippe grabbed a cardboard sign from a fan. He tucked it under his jersey to keep warm on the descent. Later, he apologized to the woman. The sign read: “Wout doesn’t know it yet, but we’re getting married!” Today, the woman was a guest in the paddock, warmly welcomed by both Julian and Wout. This is what cycling is all about! 🤗

Verrassend nieuws ! universiteitleiden.nl/nieuws/2025/07…

@GillesvanWezel @hmcg Real bummer Gilles, hope you'll recover swiftly ! 🍀🍀

a big shout out to @HMCG His Majesty's #Coastguard in #Cornwall for rescuing me after breaking my ankle on a tricky spot on the coastal slopes near Tintagel. Thanks to the 8 fantastic volunteers who carried me through the steep hills to safety. You made the difference.

Check out this @NatureComms publication and thread 👇 interesting and grand piece of work, largely carried out by @minrui_Ren in the lab of @LennartSchada. Thanks for this nice and inspiring collaboration 🤗 !

Meeting of the cluster Microbiology @LeidenBiology with today focus on Fungi, Pseudomonas and marine bacteria, groups of @LennartSchada @HandeWinde @danielrozen and Arthur Ram.

mooi verhaal in de Mare van en over de zojuist overleden criminoloog Wouter Buikhuisen en de rol van @CarelStolker bij zijn eerherstel @UniLeiden. mareonline.nl/nieuws/weggepe…

BASys2: a next-generation bacterial genome annotation system | Nucleic Acids Research | Oxford Academic academic.oup.com/nar/advance-ar…

Ik heb een opiniestuk geschreven in @WeekbladMare. Aanleiding zijn de agressieve Pro-Palestina leuzen die ik hoorde bij onze Dies. Die staan helaas voor een groter probleem: er zijn studies waar mensen te bang zijn om zich te uiten en/of zichzelf te zijn. mareonline.nl/opinie/angstcu…

Engineering a phi15-based #expression system for stringent #gene expression in #Pseudomonas putida—led by @EvelineLammens, @Daniel__Volke in a nice collab between @LabNikel & @RobLavigne1's team nature.com/articles/s4200…