maurizio molinari

News on ERLAD: Calnexin:FAM134B:VAPA:ORP1L:RAB7 contact site between ER and endolysosomes to remove misfolded proteins. CNX:FAM134B-driven ERLAD of ATZ polymers proceeds via enhanced formation of VAPA:ORP1L:RAB7 contact sites between ER and endolysosomes tandfonline.com/doi/epdf/10.10…

Today’s NCB. The cytoplasmic intrinsically disordered regions (IDRs) of ER-phagy and mitophagy receptors are interchangeable, required and sufficient for the ER and mitochondria fragmentation required for lysosomal clearance of the organelle’s portions. rdcu.be/eF5DR

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉 rdcu.be/ey8iL

ATZ polymers elicit intervention of the CNX:FAM134B-LC3II segregation complex and formation of VAPA-ORP1L-RAB7 membrane contact sites that facilitate Syntaxin18/VAMP8-driven fusion of ER and endolysosomal membrane: ER-to-Lysosome-Associated Degradation. biorxiv.org/content/10.110…

I would like to warmly thank the ALPHA-1 Foundation for the important support allocated to our research project “Understanding the Molecular Mechanisms of Lysosomal Clearance of ATZ Polymers". A1F recognizes 2025 Grant Award Recipients during ATS  alpha1.org/a1f-recognizes…

New Online! Key challenges and recommendations for defining organelle membrane contact sites bit.ly/4lnIBP1

@lab_cali @NatRevMCB Nice!! Very useful!!

🚨 New review out in Nature Reviews Molecular Cell Biology! Expert recommendations for studying organelle contact sites and introduce the concept of organelle contactome 🧬nature.com/articles/s4158… Huge thanks to editor Lisa Heinke for the support and guidance! 🙏@NatRevMCB

📼 ⏮️ 𝑯𝒆'𝒔 𝑩𝒂𝒄𝒌! Bentornato a casa Gjanni! 🤍🖤 #noibianconeri #fclugano #lugano

Early morning discussion about see turtles with Jeff Brodsky. FASEB Endoplasmic Reticulum meeting, Melbourne, Florida. ⁦@FASEBorg⁩

Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing. N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology nature.com/articles/s4158…

For Dan! sites.google.com/umass.edu/danh…

Two structurally targeted allosteric regulators of GCase folding promote lysosomal transport of disease-causing variants, reduce ER stress and rescue lysosomal functions. Therapeutic potential for GD, PD, and Dementia with LB. mdpi.com/3299382 #mdpiijms via @IJMS_MDPI

Uncovering ERLAD: the ER-to-Lysosome Associated Degradation of large, aggregated, disease-causing, nasty misfolded proteins that fail to enter proteasomal-driven ERAD pathways. sciencedirect.com/science/articl…

We’re proud to share that the Alpha-1 Foundation has been named one of the 2025 Best Nonprofits to Work For by @NonProfitTimes ! This recognition reflects our ongoing commitment to fostering a mission-driven culture that values collaboration, innovation, and impact. Read more: alpha1.org/alpha-1-founda…

We wish you and your loved ones a happy and meaningful Easter. 💐

Alpha-1 doesn’t just affect the lungs, it can impact the liver, too. On #WorldLiverDay, we’re shining a light on Alpha-1 liver disease and the importance of early diagnosis and support. To learn more about Alpha-1 and the liver, visit: alpha1.org/liver-disease/ #Alpha1Awareness

Dreams … instagram.com/reel/DH5IWRyNf…

For those new to scientific research, please remember that the only thing that matters is the REPRODUCIBILITY of your study, not the impact factor or journal name. Thank you.

@weldeiry @AMCuervoLab @EinsteinMed @WeillCornell ER-phagy is missing from the slide 🤭

Ana Maria Cuervo MD PhD at @EinsteinMed speaks about Selective Autophagy: Extending health-span one protein at a time at the 228th Interurban Clinical Club meeting at @WeillCornell #ICC228