Wafik S. El-Deiry, MD, PhD, FACP

Books I have edited that may be of interest to those who study cancer. They are all available on Amazon.

@Aiims1742 @CD_AACR @CSHL To me it looks like a dragon.

The May issue of @CD_AACR features the cover article by Dave Tuveson & colleagues @CSHL on the bi-directional crosstalk between sympathetic nerves and fibroblasts within the precancer ecosystem of #PancreaticCancer. aacrjournals.org/cancerdiscover… Editorial aacrjournals.org/cancerdiscover…

And then it turned into this👇

WIN Consortium Meeting Highlights Need For Scalable AI And High-Quality Data - Wafik S. El-Deiry @weldeiry oncodaily.com/voices/wafik-s… #OncoDaily #Oncology #Cancer #Health #Medicine #MedX #MedTwitter

My husband is alive. I don’t care about your post. He was given 12 months 8 months ago. All you are showing me is the FDA doesn’t like a scientist to say his therapy works. All you are showing me is the FDA doesn’t want the public to know there is a different therapy available and are trying to silence Soon. Terminal patients don’t have time and shouldn’t have to wait for a bunch of academics to write their opinions for 20 years. If not for the “podcast” I wouldn’t have known about #ANKTIVA and NK cell therapy and my husband would be on his way out. President Trump signed right to try in 2018. The FDA needs to get out of the way.

My husband was diagnosed with glioblastoma and given 12 months to live. He has been on #ANKTIVA and PDL-1 NK infusions. He has now had 2 normal brain scans. The red tape to ground breaking therapy needs to be cut! The fact the FDA wrote Dr Pat a letter to silence him is a disgrace. People deserve to choose the path that makes sense to them. They deserve hope! They shouldn’t have to fail standard therapy to be given a chance at life. The first MRI is before, the 2nd after. @bullishbruk

Thanks for the conversation. I think there’s enough reason to 1- fully characterize the effects of spike on the DDR response using readily available tools such as pseudovirus. 2- this includes the p53 pathway, the HR pathway with BRCA proteins and various forms of DNA damage and repair. 3- studies should look at damage sensing including checkpoint kinases, the ordered recruitment of proteins to damage foci, H2AX 4- full characterization of structural requirements in spike on observed effects on DDR, p53 and BRCA1 5- impact of SV40 origin and enhancer or promoter sequences -/+ setting of prior exposure to SV40 virus (or in experimental models -/+ SV40 T-antigens) on human cells with focus on potentially transforming events and their cancer-related consequences in vivo 6- more detailed studies of the effects of COVID infection, spike protein as well as vaccine elements on innate and adaptive immunity. 7- more characterization of PD-L1 upregulation on human immune cells in the setting of COVID infection, and vaccine shots where spike protein is expressed. The beauty of science is that it can provide answers to important questions especially when there is collaboration, sharing of expertise, reagents and results.

Science is about pursuit of truth that is generally absolute in nature. The path to uncover truth takes many twists and turns often with surprising findings that open our eyes and shine light on things less obvious. The more I learn in science and medicine the more I realize how little we all really know and I think accepting when one is wrong about something allows growth and progress. Sometimes different people looking at a problem from different perspectives reveals parts of the truth but a big puzzle comes together when people collaborate for greater good. In the end scientific truth doesn’t change whether we accept it or not. Freedom of scientific inquiry: reclaiming space for controversy nature.com/articles/s4157… @VirusesImmunity

Yale Prof. Akiko Iwasaki writing in Nature: "Our inability to remain open and engage in rational discussions about controversial subjects may be eroding public trust in science." "I remember a colleague whose daughter developed a life-threatening autoimmune encephalitis after receiving the human papillomavirus (HPV) vaccine. I watched her struggle with obstacles in even asking whether her daughter’s illness might be linked to the vaccine. These questions are not only unwelcome in the field but also could jeopardize one’s career and credibility." "The pressure to stay within the consensus view is at an all-time high, for fear of reputational damage, funding exclusion and lack of career promotion, which is amplified at a massive scale on social media. However, there are broader epistemic consequences to staying within the consensus and suppressing alternative viewpoints, which could undermine trust and progress in science." "scientists are unable to freely inquire about the risk of [post-vaccine syndrome] without being labelled as ‘anti-vaxxers’." "True scientific progress depends on a culture that protects dissent"

A research revealed that roughly one in five CEOs and senior executives displays clinically significant psychopathic traits. This rate is strikingly similar to the prevalence found among prison populations. According to findings presented at the Australian Psychological Society’s annual congress, approximately 21% of high-level professionals exhibit strong psychopathic characteristics. That’s dramatically higher than the 1% to 4% seen in the general population. These so-called “successful psychopaths” often rise to the top by using charm, confidence, and strong social skills. Yet the same traits, a lack of empathy, superficial relationships, and a tendency toward manipulation, can lead to unethical decision-making and long-term harm to organizations. Forensic psychologist Nathan Brooks, who led the study with researchers from Bond University and the University of San Diego, points to flawed hiring practices as a key factor. Many companies focus heavily on skills and experience while overlooking dangerous personality traits. The researchers recommend implementing more thorough personality assessments during recruitment to screen for toxic characteristics. By prioritizing character alongside competence, organizations can better protect their culture and future from leaders who deliver short-term gains at the expense of long-term integrity. [Brooks, N., Fritzon, K., & Croom, S. Corporate Psychopathy: Highlighting the Importance of Personality Screening in the Recruitment Process. Australian Psychological Society Annual Congress]

Navigating some rough New England waters this morning in 50°F windy weather leads me to conclude this is an inhospitable environment. I told the dock master they shouldn’t let anybody get out there in these waters today because it’s only gonna get worse. 

@AttardiLaura @theNASciences Congrats Laura.

So honored to have been elected to the @theNASciences this year!

New @Nature study: >50% of lung cancer metastases are seeded by other metastases, not the primary tumor. This "seeding from seeding" reveals a complex evolutionary cascade that allows cancer to colonize the body. nature.com/articles/s4158…

I love giant machines

Four decades of HIV vaccine research have an uninterrupted track record of failure. $30-50 billion spent with ROI of zero. HIV is 100% preventable and new long-acting med therapy reduces viral load and transmission to zero. @NIH is correct to reprioritize funds toward more promising and productive purposes.

Google Scholar citation metrics over the last 5-years while at @BrownUniversity reflective of progress and sustained impact.

The original WAF1 paper is coming up on 10,000 citations in google scholar