PiehlerLab

Professorship at UOS in an excellent research environment: SFB 1557 biologie.uni-osnabrueck.de/forschung/fors…, RTG 2900 cellnanos.uni-osnabrueck.de/en/research/re… Less than a week left to apply: uni-osnabrueck.de/universitaet/s…

Terrific to write this preview in @CellCellPress with Samantha Joubran on an outstanding paper describing the structure of the THPO-MPL complex and its role in hematopoiesis from the Garcia lab: cell.com/cell/fulltext/… cell.com/cell/fulltext/…

Now online! Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis dlvr.it/Sv9s81

Our RTG "nanomaterials@biomembranes" made it into the "final 11" - many thanks to the terrific team!

We, at the Weizmann Institute of Science, are ashamed of, and dismayed by the Israeli government, who is threatening to crush all the conditions for the existence of a healthy civil society, and to act contrary to the law and the court’s order. (1/6)

🍰 Leptin is a hormone that promotes satiety. But how does it give the 'I'm full' signal? Alexandra Tsirigotaki, Kenneth Verstraete, Savvas Savvides, and colleagues @InflamResCen present the 3D structure of leptin as it binds to its receptor to give the signal. vibbio.tech/42E9sxq

Leptin receptor assembles into trimers: amazing structural work from the @SavvidesLab! rdcu.be/c8j7c

@CoskunPLID Many thanks, Ünal!

reHaloTag labeling: final version is now online: onlinelibrary.wiley.com/doi/10.1002/an…: long-lived, works with traditional HTL dyes and is ideal for single molecule tracking! Happy to share the clones, soon available from Addgene.

MP-PPI is back! aegeanconferences.org/src/App/confer…

🔬 Drs. @Steven_C_Wilson and Nathanael Caveney (@CaveneyNA) at @StanfordMed used #cryoEM, single-molecule imaging, and cell-based signaling approaches to explore the structural basis for IL-17 family signaling. 📝 @Nature | go.nature.com/3bopPsw 💬 | bit.ly/3d3UFHi

Proud to share the structure of HOPS, a spectacular tethering and fusion complex! Super work by @DmitryShvarev and tw-less Jannis Schoppe and Caroline König. Great collaboration with @UngermannLab and first structure from our Glacios Elenor! doi.org/10.1101/2022.0… #cryoEM #UOS

Finally, the exciting lattice light sheet microscopy results from the collaboration with the Reth lab. Congratulations to Deniz, Bugra and Michael: amazing imaging and analysis! biorxiv.org/content/10.110…

@ChizhikAlexey Thanks, Alexey, for your tireless efforts to design this cool cover! And for your excellent idea to support Ukrainian refugees instead of spending it for repairing your car...

A tremendous fight from Christoph - first with the experiments, then with the reviewers. Congratulations!

Many thanks to @barisch_c, Michael Hensel and Rainer Kurre for another exciting imaging workshop! Beautiful electron microscopy and CLEM from Dominique Soldati-Favre, @EnningaL, and Kay Grünewald - and the cool CLEIM work from Pierre Santucci.

@CoskunPLID Thanks Ünal - I already feel lost and overwhelmed