Richard | ISC

@RUBENZONKA @DocLibertarian @cremieuxrecueil @grok Where do you see anyone talk about retatrutide?

@Richard_ISC @DocLibertarian @cremieuxrecueil @grok they are talking about retatrutide and semaglutide. reta's the only one currently in trials

This is not good: People have learned that GLP-1s are really effective, so if they're not losing weight, they know they're in the placebo group. So these people getting placebos are getting mad and leaving the trials.

@RUBENZONKA @DocLibertarian @cremieuxrecueil @grok are wegovy and ozempic the same medication with different dosage?

@Richard_ISC @DocLibertarian @cremieuxrecueil you do know they're not...right?

@DocLibertarian @cremieuxrecueil You do know they are.. the same drug right?

@cremieuxrecueil Time for placebo studies is over. Test against standard which is now Ozempic

If cost is an issue, as I said twice now, there are many cheap offshore jurisdiction. Also there are witholding tax on dividend in the US. If you have clients in the US, you're exposing yourself a lot more than if you are offshore. Anyway, recommend anyone that sumbled upon this to talk to actual expert, not me, and not "myStableCorp".

The cost comparison is where this falls apart. Dubai free zone: $2,000–5,000+/yr minimum Singapore (nominee director): $2,000 - $3,000+/yr Wyoming LLC: $200 - $300/yr Same Indian tax obligation either way. Wildly different overhead. Also: nominee directors in SG/HK aren't just an "administrative cost" — they carry fiduciary authority over your company. That's actual risk, not just paperwork. Plus, a US bank account is what most US clients actually want to pay into.

A US LLC does NOT mean you pay US taxes. This is the #1 reason non-US founders never set one up. Let me kill this myth permanently. 🧵 #usllc #wyomingllc #indianfounder #cryptoindia #vdatax #web3india #globalfounder

You dont need to move to Dubai to setup a corporation there. Same for SG & HK beyond the director. There are all the cheaper offshore jurisdiction too. You conflate "risk" with "administrative cost". Its all legal to do from India, and they would all need to be equally reported to and taxed by India.

Great question. Short answer: those work — if you actually move there. Dubai's 0% only applies if you're a UAE tax resident (183+ days/year). Singapore and HK require physical presence or expensive local directors. Most Indian founders don't want to relocate. A Wyoming LLC doesn't ask you to move. It just changes how your income is structured and routed — while you stay exactly where you are. The "IRS risk" for a non-US owner with no US operations is one information return per year (Form 5472). That's it. Dubai is a great answer if you want to emigrate. Wyoming LLC is the answer if you want to keep building from India — legally.

@mmdhrumil Too complicated for all parties involved, perp are a better product for leverage.

What do y'all think are the biggest reasons why on-chain options are still not as successful as perps? I know a bunch of them got started on Solana too 👀

@therealchaseeb @vibhu @tokens Reminds me of when we first started on Solana, and be completely lost when I tried to figure out where to trade. Bonfida was at the top of the list on Solana directory 🤦‍♂️ Thankfully we went to a hacker house and quickly got our bearing.

@therealchaseeb @vibhu @tokens Kinda. You're asking a normie, a newcomer, to figure out which platform to use amongst 6. 3 of which arent place that users should pick to swap (AMMs). Even a guy from EVM used to Uniswap might default to one of the DEX. And thats the general issue of foundation.

So, you're telling me, that @tokens is breaking market news and then pushing people to the website and showing them where to buy the tokens in the solana ecosystem? Seems bad

@FayeFlix Stop wasting your time on reddit. Its gone.

@YearOfTheKraken Rational -> reasonable. Israel is rational. They want to turn Iran into a fail state, and weaken other gulf countries. Nethanyahu hasnt been happier in his life.

Many people wouldn't have liked it when I called Iran a rational actor. But consider their actions so far. -Did not close Strait of Hormuz until there was an existential threat to their country -Did not attack critical energy infrastructure until theirs was targeted -They have once again threatened that they will destroy the regional energy infrastructure if theirs is attacked, prompting Trump to announce no more of Iran's will be targeted -They have demonstrated the capability to destroy the entire energy infrastructure of the Gulf and yet, they are holding themselves back. Compare this with Israel and USA's actions so far: -Decapitation strike against Iran while negotiations were progressing well (Oman confirmed this) and a ceasefire was in place. -Targeted Iran's energy infrastructure knowing fully well that there will be retaliation. -Initiated a war they have no means of winning without plunging the entire world into an apocalypse. Which side is the rational actor here?

@gal_stern Axios and Hyperliquid pretty much solved it imo

Hot take: no wallet or app has actually fully abstracted the onchain experience. Users still need to think about chains, gas, slippage etc. Who's aiming towards this user experience? Let's talk

@rushicrypto The Collapse.

If the last one was named “The Great” Depression, what’s this one going to be called?

@TheReeveOliver @c542870 @Ldnbox You are both correct and naive.

@c542870 @Ldnbox Im well aware of the mechanism he used. Im pointing out that it is unethical (imo) and shows the founder is unqualified to be running a SAAS platform.

SaaS founder realizes they may have accidentally built the backbone for a drug trafficking operation. 😜

@myStableCorp Why not a 0% jurisdiction? Or Dubai, Singapore, HK? Any of those would make anyone life easier. Why risk dealing with the IRS...

6/6 This myth — "I'll pay US taxes" — has stopped thousands of Indian founders from building the right infrastructure. Now you know the truth. Questions? Drop them below. Our CA reads every reply. Follow for more on building a compliant global business from emerging markets, starting from India and Nigeria.

For anybody saying "Just use Linux", you need to realise that Linux is worse than Windows. Windows has all the bloat, and while you can have Linux without any of that you still don't have tools like Remedybg, RAD Debugger and Super Luminal. Once you have such tools, then Linux is a suitable app development environment. But _it is still trash_ because of the whole Linux model of you needing to compile everything. The fact that you cannot run an app built using a newer version of glibc is an insane decision. I shouldn't have to upgrade my whole machine in order to run something built on a newer version. I shouldn't be worried that an upgrade will break my machine. I shouldn't be forced to compile things from scratch to work on my machine. I shouldn't be forced to install N packages, I just want self contained binaries I can just download and run. I shouldn't be forced to develop with an old distro to have "max glibc compatibility". I shouldn't have to worry about X11 / Wayland / Window Managers. I shouldn't have to worry about asking the user to select a folder, display a dialog or show notifications. Linux is such a huge waste of potential, if they got their shit together they would completely obliterate Windows. I first got into Linux in 2000, and even back then there was this "it will take over Windows any time now!". It's been _26 years_! The same way I'd pay quite a lot for Windows without any bloat, I'd be willing to pay for a distro that gives me all this.

@cavemanloverboy Hyperliquid?

s&p500 perp without mcp lesson in there

@SavageBot14 @haugejostein Both countries are being targetted because they don't play ball with the US. There are about 60 countries with authoritarian regime. Many of which are US allies (UAE, Saudi Arabia). You're naive if you think it's about helping the people in those countries.

@Richard_ISC @haugejostein We are extending our influence but you girls call that “bullying”. We ended Maduro’s reign and his drug trafficking and now we are ending Iran’s 47 year run of terrorism but we’re the bullies?

In October 2025, an overwhelming majority of the UN General Assembly voted to end the brutal US embargo against Cuba. For the *33rd consecutive year.* Tell me, who’s the rogue state here?

@SavageBot14 @haugejostein The US under Trump is bullying other countries.

@Richard_ISC @haugejostein Pick your poison. What you call a “bully”, Americans call “balls and strong leadership” over the last disaster we had in office.

@iamzhe @triton_one Ah, im not sure @SteveCleanBrook

@Richard_ISC @triton_one get started without going through a sales call

To save cost, we were considering switching away from @triton_one. Recently, our needs were significantly reduced. But they introduce "pay-as-you-go": our bill went $500 -> $30/m. Still have access to their whole infra and services. We're staying!

@iamzhe @triton_one Wdym by self serve?

@Richard_ISC @triton_one are they self serve yet? they were gated for years afaik