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The West Lab

The West Lab

@SCWestLab

The West Lab @TheCrick studies mechanisms of DNA Recombination and Repair. Tweets by lab members, unless signed SCW. Views are own

London Sumali Aralık 2022
253 Sinusundan721 Mga Tagasunod
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The West Lab
The West Lab@SCWestLab·
We are very excited today to share our work in @Nature defining the mechanism of human RAD52 mediated single-stranded DNA annealing in cooperation with replication protein A (RPA) nature.com/articles/s4158…. Thread ⬇️⬇️⬇️ (1/8)
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Costa Lab
Costa Lab@CostaLabCrick·
Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m
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ConstantinouLab
ConstantinouLab@ConstantinouL·
We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: tribute2angelos.fr/page/home/
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Fusion Conferences
Fusion Conferences@Fusion_Conf·
📣#RECOMBINATION25 PROGRAMME NOW LIVE! Exciting news! The first draft of the programme for the 2nd Recombination Mechanisms conference is now available. 🌟 🗓Important Deadlines: Early Bird & Talk Submission – 28 Nov 2024 Poster Submission & Registration Deadline – 13 Mar 2025 Don’t miss out—check out the programme and get all the details here: bit.ly/4ekGnMz
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The West Lab
The West Lab@SCWestLab·
@Jiangchuan_Shen While we observed interaction between the N-terminus of RPA (DBD-F, DBD-A and DBD-B) with RAD52, it is dispensable for the stimulation we observed in the single-stranded DNA annealing assay (Extended Data 11g).
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The West Lab
The West Lab@SCWestLab·
We are very excited today to share our work in @Nature defining the mechanism of human RAD52 mediated single-stranded DNA annealing in cooperation with replication protein A (RPA) nature.com/articles/s4158…. Thread ⬇️⬇️⬇️ (1/8)
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The West Lab
The West Lab@SCWestLab·
Our structural, biochemical and biophysical analyses provide a model by which human RAD52 open-ring cooperates with RPA to facilitate single-stranded DNA annealing repair. Our findings may provide new ways of targeting RAD52 in BRCA2 deficient tumours (7/8)
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The West Lab
The West Lab@SCWestLab·
Merry Christmas from the West lab 🎄
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The West Lab
The West Lab@SCWestLab·
Our latest paper uses structural biology, biochemistry & biophysics to reveal the two-step catalytic mechanism of the human nucleotide pool sanitiser DNPH1. This will aid the development of novel inhibitors, which may be of use in breast cancer treatment. nature.com/articles/s4146…
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The Francis Crick Institute
The Francis Crick Institute@TheCrick·
We awarded our annual Translation Prize last night, recognising researchers at the Crick who are applying their research in a real-world setting. Congratulations to our winner Anaid Benitez, runner-up Andreia Bernardo and all the nominees! 🏆🎉crick.ac.uk/news/2023-10-1…
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Tuklasin

@Jiangchuan_Shen @Nature @LukeGreenhough @ilirjanabajrami @Tuppi1987 @TheCrick @BBSRC @ERC_Research