Foo Lab

In @ScienceMagazine we used single cell multiomics, human PET imaging, and in vivo lineage tracing to identify FAP as a marker of modulated vascular cells in coronary artery disease. We used anti FAP BiTE therapy to reduce plaque burden in vivo. science.org/doi/10.1126/sc…

Another year, another retreat for the Foo lab, this time in the shabby chic Lotus Resort at Desaru, Johor Malaysia. Getting to know you, learning science from each other, scientific mentorship and leadership practice. @NUSMedicine @TheFooLab

Plz repost! New Postdoc Position: Join our lab at UA Sarver Heart Center to develop nanoparticle & protein delivery platforms for cardiac regeneration. PhD in nanotech/biomed eng/pharm sci required; in vivo delivery a plus. Email: sadek@arizona.edu #Postdoc #Nanomedicine #Regeneration

We discover RUNX1 as a nodal regulator of human cardiac recovery and uncover a druggable epigenetic mechanism in macrophages that orchestrates functional, structural, and molecular features of organ recovery @LavineLab @m_alexanian @Amgen @ImmunoFibHF biorxiv.org/content/10.110…

Our Spatial Transcriptomics study of human #aortic full thickness punches shows smooth muscle cell clusters in early atherosclerotic #plaque, and an iron-driven macrophage-like cell state that can be targeted to prevent progression @10xGenomics @TheFooLab biorxiv.org/content/10.110…

@CircRes Interorgan Crosstalk in #HF & #Cardiometabolic Diseases Compendium CV, #Kidney, #Liver, & Metabolic Interactions in #HF: Breaking Down Silos ahajrnls.org/3ZtHfJQ by @rsyf2 @josephahill @FaiezZANNAD @ShahzebKhanMD @JenHoCardiology @leahkosyakovsky et al

Organs don't work in silos !! It's time to track outcomes across the disease specialities, when they are so much metabolism driven today @NUSMedicine ahajournals.org/doi/full/10.11…

We use CITE-seq, Xenium, human PET imaging, and in vivo lineage tracing to identify FAP as a marker of modulated SMCs in human coronary artery disease and show that treatment with an anti FAP bi-specific T cell engager reduces plaque burden in vivo biorxiv.org/content/10.110…

Open faculty positions announcement: 2 advanced HF faculty positions are available at The University of Arizona. All faculty ranks. Competitive salaries and startups. Message me for more details. Plz repost.

None of this team entered science to make a high salary. Several could well have a luxury life doing something else. So each time we get a chance to let the hair down and put fun into our science and team building, we make the best of it. A lab retreat to remember @TheFooLab

The wonderful joys of hanging out with younger people...and learning from them about their aspirations and big dreams @TheFooLab going into the new year (early) @NUSMedicine @CvdNus

Grateful for the plug for RESET. We are still on a drive to enrol participants..... free scans and tests, and a 5yr long follow up with the medical team... on a look out for causes and drivers of early heart and metabolic disease @CvdNus @TheFooLab medicine.nus.edu.sg/reset_landing/

#ICYMI: Asns marks cardiomyocyte dedifferentiation @yike_zhu @TheFooLab @NUSingapore @NUSMedicine @chesterleedrum @zentiang @meekelee @Circulation @rsyf2 #AHAJournals

Early access link below ! : ahajournals.org/doi/abs/10.116…

We've found that the cell adherens junction is crucial for cardiomyocyte development through the NF2-YAP-AMOT protein complex @NUSMedicine @NUSResearch @CvdNus @TheFooLab @Meekelee

So much good science and fun with old and new friends at #KSCardioEpi24 Hannover Harrenhausen palace. Till we meet again ! #Cardiovascular #Epigenetics #GeneRegulation

Explore emerging #Cardiomyopathy #Transcriptomics #cardiomyocytes research with field leaders @KeystoneSymp Cardiovascular Epigenetics and Gene Regulation, this April in Hannover! keysym.us/KSCardioEpi24 #KSCardioEpi24 Catch the discounted reg rates before valentines day !

Our first manuscript in 2024 published on @eLife Human genomic safe harbours, transgene shutdowns no more ! elifesciences.org/articles/79592

Cardiovascular teams at #nus #cvmdtrp gathering marking the end of the year !

Year end lab meeting ! Featuring: Santa claus and the red nose reindeer ?