paul naphtali

this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get

Cursor for Slides is finally here Watch the first 47 seconds. Then try going back to your old deck tool Reply "Chronicle" + RT to get two months of Pro for free. Make sure you follow so I can DM you asap.

@tejgw @etherington Chronicle

@duellsy 👀

OK, I've spent enough time tinkering, time to release and work in public.

Of course that's your contention. You're a first-time SaaS bear. You just got finished listening to some podcast, Dario on Dwarkesh, probably. Now you think it’s the end of white collar work and seat-based pricing is screwed. You're gonna be convinced of that til tomorrow when you get to “Something Big is Happening”. Then you’ll install ClawdBot on a Mac Mini, vibe code a dashboard on top of a postgres database and say we’re all just a couple ralph loops away from building a Salesforce competitor. That’s gonna last until next week when you discover context graphs, and then you're gonna be talking about how the systems of record will be disintermediated by an agentic layer and reposting OAI marketing graphics. “Well, as a matter of fact, I won't, because ultimately the application layer is just ….” The application layer is just business logic on top a CRUD database. You got that from Satya’s appearance on the BG2 pod, December 2024, right? Yeah, I saw that too. Were you gonna plagiarize the whole thing for us? Do you have any thoughts of your own on this matter? Or...is that your thing? You get into the replies of anyone posting a SaaS ticker. You watch some podcast and then pawn it off as your own idea just to impress some VCs and embarrass some anon who’s long SaaS? See the sad thing about a guy like you is in a couple years you're gonna start doing some thinking on your own and you're gonna come up with the fact that there are two certainties in life. One: don't do that. And two: you dropped thirty grand on Mac Minis and LLM API calls to come to the same conclusion you could’ve got for free by following a handful of VC accounts.

@LoganTGott Playbook

LinkedIns algorithm changed dramatically in 2026. Only a small group realized and is taking advantage currently I decided to compile EVERYTHING needed to grow and sign clients on LinkedIn: → Profile optimization that positions you as the authority → Content strategy that brings in qualified followers → Lead magnet framework that brought me 500+ leads from ONE post → Outbound system that booked 5 calls from 122 DMs in a week → Hook frameworks and visual strategies that 10x engagement → Implementation timeline to execute everything properly One client increased quality impressions by 1,117% in 90 days. Another generates 30+ qualified leads monthly with this system. The founders who understand how LinkedIn actually works are eating while everyone else posts AI slop that gets ignored. Want the full 2026 LinkedIn Playbook? Follow me & comment "PLAYBOOK" I'll DM it to you soon

@StirlingHowland @AdameMedia ?

@AdameMedia It’s always been captured.

Alex Jones is frustrated that people keep talking about Israel. He replaced Owen Shroyer with an extreme Zionist. Infowars is a controlled op.

@JamesAlcorn94 Congratulations James, great news

We have raised $9B in fresh capital to back founders doing their life's work nytimes.com/2025/12/15/tec…

Hey @mattallen, want to do end of year drinks again this year? How's 18 Dec? Last Thursday before Xmas traditional get together at the Cherry Tree?

Running City2Surf tomorrow with my son Harry, for the first time (in fact, running a 14km “fun run” for the first time) Running for a great cause, if you feel inclined to support the Black Dog Institute for mental health, it would be terrific: city2surf25.grassrootz.com/blackdoginstit…

NEW Episode of The High Flyers Podcast is now live! #193 Paul Naphtali: From PR to VC—Silicon Valley Lessons, Building Rampersand & How great founders win (in a rare public interview) curiositycenter.xyz/the-high-flyer…

@vidags10 @rampersand_fund @abhim_eth @PieterseTaryn Thanks Vidit. It was a pleasure chatting with you and covering some ground that I hadn’t really talked about before

@QuantumBrillia1 has secured US$20M in strategic funding as part of its Series A round! 🚀 This funding will drive the establishment of a Quantum Diamond Foundry in Melbourne, marking a major leap forward in making Quantum Brilliance’s technology scalable and deployable—paving the way for breakthroughs in quantum sensing and computing. #QuantumComputing #DeepTech #Innovation

Thanks to all who came to the 2024 end of year Cremorne/Melbourne startup drinks. Biggest year yet ⁦@mattallen⁩ . Wishing everyone a great holiday season and looking forward to an exciting year ahead

Hey @mattallen , want to have a drink at the Cherry Tree this afternoon?

I prefer to think of it as the Cremorne (and nearby) all-comers end of year celebration! Everyone welcome, this Thursday 19th at the Cherry Tree from mid-afternoon. See you there 🍻

@KiwiTiger12 Congrats Slowy - very well deserved 👏

It's a privilege to volunteer. When it's the club you love, it's an even greater level. Very grateful. #gotiges

Late entrant for ‘lighthearted thread of the year’ 🤓