The Arany lab

New! Online now: Quantification of nutrient fluxes during acute exercise in mice dlvr.it/TFMr8Y

Reporting with pride: (1) our star Jessie Axsom is now Dr.! (2) her paper is out @Cell_Metabolism: unbelievably comprehensive quantification of fuel fluxes in #exercise mice - lots of surprises. #MoTrPAC: take note. w/Rabinowitz lab. Free link 50days: authors.elsevier.com/a/1jxL75WXUlWk…

Fantastic brief historical overview of mechanism behind #preeclampsia from brilliant friend @ananthmsn34 in @jclinicalinvest : jci.org/articles/view/…

From our newest anniversary focus issue on #Metabolism! "Human cardiac metabolism" @AranyLab @PennMedicine & colleagues Read the review: cell.com/cell-metabolis… #50YearsofCell

We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! biorxiv.org/content/10.110…

it's been a while since we posted... Here our recent review w/ @Rongtian2 on HUMAN cardiac metabolism in @Cell_Metabolism : deep dive going back 50+yrs - turned out to be >300 refs! Much is known, much MORE needs figured out... cell.com/cell-metabolis…

CVI's Highlighted #PapersoftheWeek pubmed.ncbi.nlm.nih.gov/39041214/

Translating metabolic and cardiovascular research into effective treatments: What’s next? Some thoughts from several of us on the topic, in this issue of Cell: authors.elsevier.com/a/1jUX4L7PXqREY @JuleenRZierath @JolandavanderV4 @Alicardsdoc @rosenzweig_a @DebMuoio

@SeanM_Wu @IntMedAbel @UCLAHealth @AHAScience @BCVSearlyCareer @Joseph_C_Wu @Rongtian2 @RonglihL Appreciated the shoutouts, thank you Dale -- wonderful talk, as always!

Keynote lecture by Dr Dale @IntMedAbel @UCLAHealth on cardiac metabolism and obesity @AHAScience #BCVS2024 describing the various energetic production sources that change during heart failure. @BCVSearlyCareer @AranyLab @Joseph_C_Wu @Rongtian2 @RonglihL

I am pleased to share a preprint ‘HIF2α-dependent inhibition of mitochondrial clustering of glutaminase suppresses clear cell renal cell carcinoma’. biorxiv.org/content/10.110…

A few days late:  Congratulations to Daniel @daniel_baker_j for winning the 2024 @Phacilitate Young Scientist Award from Advanced Therapies Awards — including Glittering Gala dinner in Miami !

New manuscript from our group studying DCM-TTNtvs and transcriptional modulators that reverse haploinsufficiency. ahajournals.org/doi/10.1161/CI…

Interested in TTN/DCM? Check out current edition of @jclinicalinvest. 2 new reports: 1 by us w/ @Arany Lab and 1 from Miklos Kellermayer, plus commentary by @TravisHinson and Stuart Campbell. We know a lot more about TTN pathomechanisms! ...and we know what we don't know. 🧵1/4

14 key points from our recent review on peripartum cardiomyopathy #PPCM in @NEJM , summarized in @ACCinTouch , thank you @MelindaDavisMD. acc.org/Latest-in-Card…

@NBCNews Thank you for featuring our work looking at delayed diagnosis with peripartum cardiomyopathy #PPCM. Important story to get out there!

Hundreds of thousands of U.S. patients are harmed or die each year because of diagnostic errors. Women and minorities are up to 30% more likely to be misdiagnosed than white men. nbcnews.com/health/health-…

Review Article by Zoltan Arany, M.D., Ph.D. (@AranyLab): Peripartum Cardiomyopathy nej.md/48pUCx3 #Cardiology

Our latest review on peripartum cardiomyopathy #PPCM in @NEJM this week -- review of mechanism, genetics, clinical management, epi and prognosis -- lots of unknowns, huge racial disparities. Hope you enjoy it! nejm.org/doi/full/10.10…

High fat consumption & blood pressure elevation ft. @BoaKim5, @WencaoZhao, Soon Tang, @MGLevin, @_AyonIbrahim, Yifan Yang, Ling Lai, Jian Li, @FitzGerald__Lab, @AranyLab (@PennCVI/ @PennIDOM) Emilia Roberts & Richard Assoian (@PennSysPharmATT) tinyurl.com/35b3tfm5

Cool:  Lauren has just been selected to serve as the intern on the American Society of Nephrology Policy and Advocacy committee for Jan-Dec 2024 !  First non-postdoc/fellow that they’ve accepted, apparently! Congratulations !! @metabolauren @ASNKidney

Deadlines are approaching for @KeystoneSymp #Cardiometabolic Diseases: #EthnicDiversity in #PrecisionMedicine, this February in Vancouver! See scholarship, abstract and discount reg dates: keysym.us/KSCardiometab24 #KSCardiometab24 #Cardiovascular