Grant Stewart

Awesome collaboration with @SPJacksonGroup, Chris Carney and Soren Hough, understanding how inherited mutations in the MEAE E3 ubiquitin ligase causes disease by compromising HR-dependent replication fork protection/restart. link.springer.com/article/10.103…

Finally our collaborative paper on inherited mutations in the actin nulceating factor, DIAPH1, spear-headed by the Houlden lab, @RMaroofian, Valentina Galassi Deforie, @StephanieEfthy1 and Peter Arkwright, is out in Genetics in Medicine. gimjournal.org/article/S1098-…

@StaplesLab @HombreRRo Nice one Chris!

New paper from the lab in collaboration with Unterholzner and Cejka groups. IFI16 protects stalled forks and is required for IFN-driven rescue of nascent DNA degradation. sciencedirect.com/science/articl…

@VSmitsLab Thanks for hosting me. Very enjoyable visit with two great people.

Thanks for visiting, Grant Stewart! @GS_Lab_Bham Great science and good company!

Interested in inherited chromosomal instability syndromes and DNA repair? We are looking for an enthusiastic person to join the Stewart lab at the University of Birmingham as a senior technician. If you are interested, please have a look at the job advert: jobs.ac.uk/job/DPH515/sen…

Great work by the Kitagawa lab about DONSON regulating centrosome duplication is finally out in Nature Comms nature.com/articles/s4146…

Great paper by the Vaziri lab about the role of RNF25 regulating the DDR independently of its E3 ligase activity! nature.com/articles/s4146…

New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling @CellReports. Congratulations to first author Antonio Galarreta and to all co-authors. cell.com/cell-reports/f…. #Microscopy #RNAiScreen #Condensates

A transcription balance required for genome stability 🧬⚖️ Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on ⁦⁦@NatureSMB⁩ #CryoEM #transcription nature.com/articles/s4159…

@PgGarcialab Well done. Lovely bit of work.

Delighted to announce that our paper showing the generation of iPSc from a MDS patient & how CEBPA drives disease progression is finally out in Nature Comms! A big thanks to everybody involved & the great collaborators that have made it possible! nature.com/articles/s4146…

Online Now: The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells dlvr.it/TLZtS1

Online Now: The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks dlvr.it/TLZkmH

Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: nature.com/articles/s4158…. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested, closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationIni…

Awesome paper from @SPJacksonGroup and @FrogWalterLab about USP37 and TRAIP regulating the replication response to topoisomerase inhibitors. Glad to be a part of it. nature.com/articles/s4146…

Our new paper describing the RNF114 protein as a reader of dual hydrid modification composed of ADP-ribose and ubiquitin (ADPr-Ub) we discovered a few years ago (collaboration with the lab of Gerbrand van der Heden van Noort) biorxiv.org/content/10.110…

Proud to present our work identifying a role for DIAPH1 and gamma-actin in regulating DSB repair and how defects in this pathway give rise to human disease. Big thanks to everyone involved, especially Beth Woodward, Sudipta Lahiri and Anoop Chauhan. nature.com/articles/s4146…

Great collaborative study just out in Nature Communications about RNF168 regulation by PIN1. nature.com/articles/s4146…

Finally out! Congrats! @AndHR11 @SJimenoGonzalez @pmmargar @JoseT86910859 J. Lieberman and G. Millán Hope we contribute to the idea of supercoiling as a key regulator of genome metabolism, and not just a side-product of DNA transactions. More to come ... cell.com/cell-reports/f…