Xuan Li_Lab

Only 3 weeks left to submit abstracts for our ECR symposium in Sheffield on 26th April! Head here for details and to submit your abstract: bscr.org/meetings/ecr24

Little News and Views @GroupXuan and I wrote. Still disappointed they didn't let us use the pun-tastic: You CANT(os) have CHIP(s) with JAK(ets) or your plaques may (fibro)Blast apart - but blocking IL-1b may help. doi.org/10.1038/s44161…

👉rdcu.be/dwftb

Our( with @MurrayClarkeLab ) News & Views (rdcu.be/dwftb) for @NatureCVR research article nature.com/articles/s4416…

Pleased to see our study is highlighted as the Editor's pick in JCI This Month. jci.org/articles/view/… jci.org/this-month/202… Thanks to @TheBHF

@antongistera @josejfuster @lassefolkersen @Hagberglab @antongistera thanks for all the organizers for your invitation. Broadly-covered research topics & great interactions & beautiful scene!

Karolinska Cardiovascular Research Retreat 2023. Thanks @josejfuster @GroupXuan @lassefolkersen @Hagberglab and all participants. 🫀

VSMCs are efficient activators of IL-1β that do not use canonical inflammasomes or caspases. Hence, this alternative pathway could be targeted for long-term treatment of CVDs, as it is not central to everyday host defence @MurrayClarkeLab @society_eas 🔗atherosclerosis-journal.com/article/S0021-…

N&V by @Prosser_Lab on the recent study by @C_M_Loescher, Johanna K. Freundt et al. pinpointing the contributors to #myocardial passive #stiffness. @PennMedicine|nature.com/articles/s4416… 👉rdcu.be/dqdpJ

Nature research paper: IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer go.nature.com/40oH0PI

PoV: your main PhD paper is finally published but the Uni's comms office decides that your cell biology and immunology research is best represented by a *big ugly foot* 👣 Still super proud, though. Great team effort @GroupXuan cam.ac.uk/research/news/…

@m_baldri 🥳&😂

This cover image for our research article jci.org/articles/view/… shows inflammatory macrophages with many NLRP3 signals (green) around the microtubule-organizing centre (microtubules in red). Taken by Yang Li & @chenxiao027 using Zeiss LSM980 with airyscan 2 @zeiss_micro

We show targeting microtubules via pharmacological drugs to inhibit PLK1 could provide a treatment strategy for inflammatory diseases characterized by excessive NLRP3 activation. cam.ac.uk/research/news/…

Cancer drug could hold hope for treating #inflammatoryDiseases including gout and heart diseases @Cambridge_Uni @jclinicalinvest doi.org/gs2842 medicalxpress.com/news/2023-11-c…

Check our paper published at JCI, featured as cover for this issue. Brilliant team members (@m_baldri Christain Doreth Yang Li @DrEmilyFW …) and collaborators (@zxh1121 @MurrayClarkeLab @GdC_CCCB_lab @m_malumbres @ZMallat…) for this collective effort. Thanks to @TheBHF .

#Cover: PLK1 regulates NLRP3 inflammasome activation by controlling microtubule organization: buff.ly/3MmUEgj @GroupXuan @m_baldri @zxh1121 @DrEmilyFW @MurrayClarkeLab @GdC_CCCB_lab @m_malumbres @ZMallat #CellBiology #Immunology

CAPture, a centrosome affinity purification method for mammalian cells, is finally out🥳 sciencedirect.com/science/articl… We found that a short peptide of CCDC61/VFL3 can be used to isolate centrosomes / basal bodies cell lysates