HeilemannLab (👉🏻 heilemannlab.bsky.social)

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HeilemannLab (👉🏻 heilemannlab.bsky.social)

HeilemannLab (👉🏻 heilemannlab.bsky.social)

@HeilemannLab

Single-molecule biophysics lab at Goethe University Frankfurt. Super-resolution microscopy. We moved 👉🏻 https://t.co/hdHe9Trgyb

Frankfurt, Germany شامل ہوئے Eylül 2021
124 فالونگ1.1K فالوورز
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HeilemannLab (👉🏻 heilemannlab.bsky.social)
HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·
Two great days of science at the #SMLMS2022, culminating with a conference dinner on the boat on the Seine. So many great conversations 🙏. Happy to present our choreography to show our appreciation to this event (watch the light pattern!).
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Beck Laboratory
Beck Laboratory@Beck_Laboratory·
… and perfect timing. Work by @HuaipengXing with @FrydmanLab out @Nature. PDCD5 binds virtually all open #TRiC, while closed TRiC forms clusters inside of cells. Congrats to all authors. rdcu.be/d3dmN
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HeilemannLab (👉🏻 heilemannlab.bsky.social)
HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·
By labeling the architectural RNA NEAT1 in paraspeckles (PS) at various positions using RNA-FISH-DNA-LNA probes, we learnt 3 new things: (1) the morphological space & shape progression of PS, (2) the orientation/packing of its RNA, (3) the coarse conformation of NEAT1. (2/3)
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HeilemannLab (👉🏻 heilemannlab.bsky.social)
HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·
We modified our STED🔬to make it more efficient ('smart') to acquire high-resolution data of small and rare objects in a 3D cell volume. This enabled collecting a large amount of data in a fully automated fashion. With that, we visualized the ultra-structure a nuclear body👇🏻(1/3)
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HeilemannLab (👉🏻 heilemannlab.bsky.social)
HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·
Long-term single-protein tracking up to 30 min allowed monitoring the dynamics of EGFR activation in living cells (and more)👇🏻Great work by a fantastic team and great collaboration with @JulianKompa Kai Johnsson @mpi_mr_hd 🙏 @sfb1507 @goetheuni
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Angewandte Chemie@angew_chem

Long-Term Single-Molecule Tracking in Living Cells using Weak-Affinity Protein Labeling (Mike Heilemann and co-workers) @HeilemannLab #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

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HeilemannLab (👉🏻 heilemannlab.bsky.social)
HeilemannLab (👉🏻 heilemannlab.bsky.social)@HeilemannLab·
🙏happy that this article is out now: we used an integrative approach (MD, single-molecule imaging, FRET) to reveal early activation of the receptor tyrosine kinase MET in cells👇🏻A wonderful collaboration with @CovinoLab & great co-workers 🙏@goetheuni @fias_science @sfb1507
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Roberto Covino@CovinoLab

Check out how we used simulations and single molecule FRET to determine how a invasion bacterial protein activates a plasma membrane receptor to enter our cells. Kudos to @serena_arghittu and @gabriel_hella, and great collaboration with @HeilemannLab nature.com/articles/s4146…

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Nano Bio Optics Lab (Yoav Shechtman)
Nano Bio Optics Lab (Yoav Shechtman)@ShechtmanLab·
Gen-AI producing fancy data augmentation for Super-resolution microscopy! Great work @AlonSaguy and team! @HenriquesLab @HeilemannLab
Ricardo Henriques@HenriquesLab

If robots could dream of microtubules, how would they look like? An amazing story by Alon Saguy, @ShechtmanLab and colleagues. Proud we could contribute to it onlinelibrary.wiley.com/doi/10.1002/sm…

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Achillefs Kapanidis
Achillefs Kapanidis@AchillesKap·
3 weeks to go... send us your single-molecule bacterial stories for our Cotswolds get-together!
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Viktorija Glembockyte
Viktorija Glembockyte@glembockyte·
Excited to share that this fall I will be starting a group at Max Planck Institute for Medical Research in Heidelberg @mpi_mr_hd! Join our team if you are interested in exploring the nano world one molecule at a time 🧬🔬 mr.mpg.de/14599619/singl…
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Siewert Hugelier
Siewert Hugelier@SHugelier·
Interested in a fully automatic analysis pipeline to quantify and classify your 2D and 3D Single-Molecule Localization Microscopy (SMLM) data in an unbiased way? Have a look at our latest work covering ECLiPSE, developed in the @Melike_Lak lab! doi.org/10.1038/s41592… 1/11
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Dedecker Lab (dedeckerlab.bsky.social)
Dedecker Lab (dedeckerlab.bsky.social)@DedeckerLab·
Very happy to share the 'Circulator' paper, which is now out in @naturemethods ! 🥳 👉rdcu.be/dTa4v Together with @vandenberglab!
Nature Methods@naturemethods

Out today from the Vandenberg and Dedecker labs! PSF splitting with the ‘Circulator’, which encodes the fluorophore emission band into the PSF, improves the information content of fluorescence microscopy and enables improved super-resolution imaging and single-particle tracking.

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Julien Hiblot
Julien Hiblot@JulienHiblot·
Why reinvent the wheel when you can enhance it? We’ve focused on making SNAP-tag better. @SteffiKuehn developed SNAP-tag2, with an optimized substrate. Faster labeling, brighter fluorescence-this is the upgrade you've been waiting for!
Stefanie Kühn@SteffiKuehn

Preprint alert🚨Did you ever experience issues in labeling kinetics and fluorescence brightness, when working with SNAP-tag in live cells? Our newly developed SNAP-tag2 system might be the solution! 🚀Check out our latest preprint on #bioRxiv: 🔗biorxiv.org/content/10.110… (1/4)

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دریافت کریں

@HuaipengXing @FrydmanLab @Nature @UK_Muenster @uni_muenster @goetheuni @ashwin0512 @JulianKompa