Spirochrome

Spirochrome is on Bluesky! Don't forget to give us a follow when you make it there, we'll follow you back! 🦋🦋🦋

And it's not all: For an exceptional new product, an exceptional new casing! We designed new boxes that we will gradually deploy to replace our old metal boxes. 4 designs will be randomly used for each product!

Today is the Day, CenSpark650 is available! Time to get those centrioles and cilia shining under the 🔬objective! spirochrome.com/product/censpa… video: 20h imaging of primary cilium formation in a single RPE-1 cell stained with CenSpark650. movie credits: Cédric Pourroy

We strongly recommend reading the article by Cedric Pourroy et al. to get to know everything CenSpark650 can do and beyond: nature.com/articles/s4158…

📢On June 1st, we will be launching CenSpark650, the very first selective fluorescent probe for imaging centrioles and cilia in live cells.🔬 No transfection, zero genetic manipulation. Just Add & Image 1 hour later. Learn more: spirochrome.com/12-may-2026/ #Bioimaging

Casually posting this one for no particular reason! #MayTheFourth

Overly proud that Katie Holden's image won Evident Microscopy's 6th Annual Image of the Year "Global Winner" award🏆 The image shows live iPSC-derived neurospheres. DNA (magenta) & MT (blue) were stained with our probes SiR-tubulin & SPY555-DNA probes evidentscientific.com/en/landing/iot…

If you want to know more about IPSC-derived neurospheres, we strongly advise to read Katie Holden's research article which introduces this technology: doi.org/10.1016/j.bbi.… Congrats Katie!

Mesmerizing light sheet imaging of neutrophils swarming at a yeast target! The neutrophils were labeled with SPY650-DNA (yellow) and a calcium dye (blue). This movie is part of the recent manuscript by Evelyn Strickland that we highly recommend reading! biorxiv.org/content/10.648…

CenSpark is a dual-ligand fluorescent probe simultaneously binding inner and outer microtubule sites – a configuration unique to doublet and triplet microtubules, enabling selective live imaging of centrioles and cilia across species nature.com/articles/s4158…

Such a great example of what MI-SIM can reveal! #livecell #MISIM

@EbisuyaMiki Congratulations! Amazing live cell movies with SiR-tubulin staining.

New preprint from the lab! How do tissue shapes influence cell fate decisions? By manipulating brain organoid geometry, we show that lumen rounding directs apical progenitor division mode and promotes the emergence of basal progenitors. biorxiv.org/content/10.648… 1/

🙏 @christlet for the cool "Animated Zooming" & "Animated panning" ImageJ plugins used here! 😎

Beware the SPY488-FastAct rollercoaster! We teamed up with @CSRBiotech and their incredible MI-SIM microscope to drive you through the intricate actin network of live COS7 cells stained with SPY488-FastAct. Find out more about SPY488-FastAct: spirochrome.com/product/spy488…

📢 Staining #Peroxisomes in live & fixed cells with Peroxi_SPY probes has never been so easy! There is now a very detailed @JoVEJournal video that explains it all step by step. Video link: dx.doi.org/10.3791/69405-v Peroxi_SPY probes link: spirochrome.com/products/?_cat…

Thought about it but it was not sold now in US😂

@HJRBio Not anymore! cytoskeleton.com/product/hak-ac…