Infinity Bio Inc.

Thrilled to welcome Brian McKelligon as the new CEO of Infinity Bio! Brian is an accomplished life sciences leader and we could not be more excited to have him at the helm. His leadership will accelerate the reach of our MIPSA technology and the inSIGHTs it delivers to researchers worldwide. #InfinityBio #MIPSA businesswire.com/news/home/2026…

New study offers a 25-year molecular map of MS progression. Key findings: EBV is an ongoing driver and sex-specific pathways impact phenotypic outcomes. Large-scale proteomics is vital to uncovering these hidden biomarkers and mechanisms for early intervention. Read here: rdcu.be/e7ZWe #MultipleSclerosis #MSResearch #EBV #Biomarkers #PrecisionMedicine #Proteomics #MultiOmics #Reactomics

Infinity Bio's Katy Shaw-Saliba & Ben Larman just published a new study screening 85 Ig therapy batches against 283,000+ viral peptides, revealing pandemic-driven immune shifts. Discoveries like this begin with decoding the antibody reactome. #AntibodyReactomics doi.org/10.1002/eji.70…

Large-scale study in Nature Communications highlights proteomic markers for lymphoid cancer risk up to 10 years pre-diagnosis. Validating findings across multiple large cohorts like UK Biobank provides broad mechanistic insight enabling early detection and targeted prevention. Read here: rdcu.be/e6GBZ​ #Proteomics #PrecisionMedicine #Biomarkers #Lymphoma #EarlyDetection #CancerResearch

New research uses proteomics to link salivary gland inflammation with serum biomarkers. Key finding: 16 serum proteins correlate with autoantibodies and HLA risk alleles. We suggest adding antibody reactome profiling to map dynamic immune histories and disease drivers / triggers. Read here: doi.org/10.1016/j.ard.… #Rheumatology #Proteomics #SjogrensDisease #PrecisionMedicine #HLA #AntibodyReactome #Reactomics

New study in @NatureMetabolism uses multi-omics to reveal the molecular drivers of Type 2 Diabetes. By analyzing millions of genetic data points and 1,600+ proteins, researchers found 923 causal genes—85% of which aren't seen in blood. Scale enables discovery! Read here: rdcu.be/e4zRC #MultiOmics #Type2Diabetes #PrecisionMedicine #Genomics #Proteomics #GlobalHealth #TranslationalResearch

New study in @NatureAging reveals the brain's "neurological clock". Analyzing CSF from 1,000+ individuals, researchers found thousands of proteins linked to aging and disease clusters. Evidence that large-scale multi-omics is key to spotting neurodegeneration decades earlier than clinical symptoms. Read here: pmc.ncbi.nlm.nih.gov/articles/PMC12… #Proteomics #Alzheimers #AgingResearch #Longevity #PrecisionMedicine

Precision medicine is powered by large cohorts. By re-analyzing WGS data from ~750k individuals in the UK Biobank and All of Us, researchers linked persistent EBV to chronic diseases like Lupus and dementia. Massive ‘omic’ datasets power these transformative discoveries. Read here: rdcu.be/e2cAt #PrecisionMedicine #Biobanks #Genomics #EBV #Biomarkers #Immunology #ChronicIllness #UKBiobank #AllofUs

Detecting cancer in vague symptoms is tough. A new study applied proteomics to human cohorts (MEDECA/ALLVOS) and found a 29-protein signature that predicts cancer with an AUC of 0.82. This is a great example of biomarker discovery in real-world clinical scenarios. Read here: rdcu.be/eZ6bE #CancerResearch #Proteomics #EarlyDetection #PrecisionMedicine #Biomarkers

New insights on the infant virome! Analyzing 647 infants in the COPSAC cohort, researchers linked anellovirus levels to genetics and environmental exposures, suggesting a role in immune training. An excellent example of key human cohorts utilized for understanding immune health. #Virome #ImmuneSystem #COPSAC #Microbiome

New research in Nature Medicine identifies core biomarkers linked to multimorbidity and aging, GDF15, HbA1c, cystatin C, leptin, and insulin. These signatures highlight metabolic control as a key driver of accelerated aging. Large cohorts make this precision possible! #AgingResearch #Biomarkers #Multimorbidity #geroscience

New research in @NatureMedicine uses large-scale immune profiling of hundreds of samples to link EBV to PSC. By sequencing T-cell and antibody repertoires, researchers found both cell types disproportionately target EBV lytic phase antigens, suggesting the virus drives pathogenesis. Read here: nature.com/articles/s4159… #ImmuneProfiling #PSC #Tcell #Bcell #EBV #Omics #LiverDisease #Autoimmunity

Groundbreaking FTD biomarkers! Hok-A-Hin et al. applied large-scale proteomics to a multicenter CSF cohort to identify diagnostic protein panels for Frontotemporal Dementia. This is critical for early, accurate diagnosis & patient selection in clinical trials. Read here: lnkd.in/eatVVT6K #FTD #Biomarkers #Proteomics #Neurodegeneration #CSF #Dementia

Exciting new allergy research!  Children with food sensitizations showed altered IgE B-cell maturation, with reduced IgE somatic hypermutation (SHM) and increased IgE diversity. This suggests B-cell repertoire signatures could be powerful new biomarkers for pediatric allergies. Read here: doi.org/10.1111/all.70… #Immunology #Allergy #FoodAllergy #Pediatrics #BCell #HygieneHypothesis #IgE

Check out this study by Thomma, Halstead et al. using the large IGOS GBS cohort. They found antibody patterns against glycolipid complexes (not just single antigens) greatly improve GBS diagnosis. These patterns also identified 7 patient clusters, which can help guide prognosis and treatment. Read here: doi.org/10.1093/brain/…

New clues for personalized treatment for variable Lupus symptoms. By clustering 846 patients via autoantibodies & genetics, researchers linked a specific gene (NCF2) to higher blood disorder risk and a HLA haplotype to lower kidney disease risk. The clusters predict a patient's disease course. Read here: translationalres.com/article/S1931-… #SLE #Autoimmunity #PersonalizedMedicine #Immunology #HLA

Diagnosing TB in children is a persistent challenge. Cohort of the week: Fossati et al. used plasma proteomics in a diverse pediatric cohort to find a non-sputum biosignature for TB. A true breakthrough for pediatric TB, the proteomic signature meets WHO diagnostic guidelines. Read here: rdcu.be/eOtzp #Tuberculosis #GlobalHealth #Proteomics #Biomarkers #Diagnostics #InfectiousDisease

Diagnosing Lyme neuroborreliosis (LNB) is notoriously challenging and invasive. A new study by Nielsen, Fjordside et al. found an accurate (0.80 AUC) diagnostic protein signature in plasma using large-scale proteomics and machine learning. Read here: nature.com/articles/s4146… #LymeDisease #Proteomics #LNB #Diagnostics #MachineLearning #Neuroborreliosis

We’re thrilled to support Scripps Research’s LoCITT Long COVID Treatment Trial! Infinity Bio, Inc. will use antibody reactome profiling to help reveal immune signatures, understand treatment responses, and drive science for better therapies. #LongCovid #AntibodyReactome #InfinityBioInc #LoCITT #ClinicalTrials #Immunology #RemoteResearch