JakobsLab

We got a belated Christmas present from @PNASNews: We made it onto the cover of the last issue for this year 😍 pnas.org/toc/pnas/curre… If you want to know more about the background, read our article about a new live-cell dye for mito imaging: doi.org/10.1073/pnas.2…

Thrilled to announce that our work on a STED simulation software designed for the validation of AI approaches and training of RL agents for autonomous control of STED imaging parameters is out now @NatMachIntell! @universitelaval @CERVO_ULaval @IID_ULaval nature.com/articles/s4225…

A team led by Steffen Sahl & @Stefan_W_Hell @mpi_nat and @mpi_mr_hd has succeeded in measuring distances within biomolecules using the #MINFLUX microscopy method, down to 1 nanometer and with Ångström precision. Read more in our press release: mpinat.mpg.de/4816514/pr_2419

Protein shapes can now be studied using ONE🔬, a combination of ExM and #fluorescence fluctuation analysis. Happy to have contributed to this paper published in @NatureBiotech with many great scientists. Special thanks to @AliHShaib and Silvio Rizzoli. nature.com/articles/s4158…

Nanometer resolution in 3D with angstrom precision! Happy to have contributed to this study led by Steffen @StefanHellLabs @JakobsLab

A nice talk from Stefan in PKU, with a lot of mitochondria, superresolution, and some twists to cryoEM in the end . Then we ended the day in the Emperior's diner for dinner😀 @JakobsLab @ZhixingChen2 @xipeng1

Beautiful work on the in situ structure of ATP Synthase by @dietrich_th from the Kühlbrandt group published today in @ScienceMagazine 🔬 Discover how this important protein complex shapes the inner mitochondrial membrane! 🧪 science.org/doi/10.1126/sc…

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Want picture-perfect STED images of TOM & Co? -> follow our detailed protocol out today in Methods in Enzymology Vol. 710 "STED super-resolution microscopy of mitochondrial translocases" Great work together with @InamdarKaushik , @cdanieljans. @JakobsLab sciencedirect.com/science/articl…

Our #STED primer is out, you can learn about tips and tricks and current challenges in STED imaging

🚀Excited to share our latest paper, where we explore dynamic changes in mtDNA heteroplasmy in living cells! Discover how asymmetric partitioning and mitochondrial dynamics drive mtDNA variant segregation! 🔬embopress.org/doi/full/10.10… #Mitochondria #microscopy #microfluidics #mtDNA

🥳🚨Paper Alert🚨🥳 Excited to present our latest work on #Opa1 in this newly published paper @ScienceAdvances by @sahola6 and @LPazurek. We present here two new mouse models with impaired Opa1 processing. 1/🧵 science.org/doi/10.1126/sc… #mitochondria #mitochondrialdynamics @MPIAGE

@IlariaTesta4 @RoyalMicroSoc Congratulations! 🎉

So grateful to @RoyalMicroSoc and truly honored for the recognition

I hope to see you all in Frankfurt at this exciting meeting! We promise, it will be worth the visit!

GBM Compact: Focus on Imaging
Frankfurt, September 26-27, 2024
Deadline for early registration and abstract submission: June 30 gbm-compact.org 👇 👇 👇 👇 👇

The GBM Compact conference „Focus on Imaging“ takes place from September 26-27 in Frankfurt! Early registration+abstract submisison is possible until June 30. Please visit the conference website for registration and further information: gbm-compact.org

"TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA" nature.com/articles/s4155…

Are you interested in the intricate biology of fluorescent proteins? Do you want to push the power of MINFLUX microscopy even further? Live-cell imaging of mitochondrial protein dynamics tickles your brain? We want you 🧐 Check out the details below 👇 jobrxiv.org/job/the-max-pl…

Here comes our next gen PK Mito Orange Fix that can be fixed to IM for you to scrutinize the wonderland of mitochondria under STED, in a multiplexed way! Many thanks for the growing PK Mito team! @stephan_till @JakobsLab and Christian Juengst! pnas.org/doi/10.1073/pn…

After countless requests, we're thrilled to introduce PK Mito Orange FX - a fixable variant of PKMO. PKMO FX allows immunolabeling and CLEM approaches. Happy to have contributed to this project led by @ZhixingChen2 and Christian Jüngst. #mitochondria pnas.org/doi/10.1073/pn…

WHAT % OF YOUR TARGET BIOMOLECULES ARE YOU REALLY IMAGING? The *labeling efficiency* of your experiment is extremely important for image quality and quantitative results in super-resolution! Super excited about our new article in @naturemethods! 🤩 nature.com/articles/s4159…