Judith Simcox PhD

Thrilled to have our story on the regulation of lysosomal lipids out in @Cell_Metabolism! The work was led by two outstanding grad students @_JessDavidson and Raghav Jain probing mechanistic control of energy expenditure @HHMINEWS @UWBiochem

主著がCellに出ました！脂肪細胞ミトコンドリアがホスホエノールピルビン酸（PEP）の輸送を介して脂質新生を担うことを示しました。また、ミトコンドリアPEP輸送体としてSLC25A35を同定しました。梶村先生を初め、共著者の方々と、支えてくれた家族に深く感謝いたします。 cell.com/cell/abstract/…

I’m excited to share new work out of the lab at @NYULangone led by @kenjifujihara! We took a first principles approach to evaluating #ferroptosis induction for cancer therapy via targeting the SLC7A11-glutathione-GPX4 axis. biorxiv.org/content/10.648…

1/3 Thrilled to see our paper led by Kirandeep Deol is out! We used CRISPR screens to uncover regulators of the ferroptosis suppressor FSP1. key discovery: vitamin B2 metabolism stabilizes FSP1 via FAD, revealing a new way vitamins regulate ferroptosis. nature.com/articles/s4159…

The first paper from the Crewe lab is online today. We found that macrophage-meditated clearance of EVs is a major determinate of circulating adipocyte EV levels. This clearance is disrupted in obesity. A huge effort by Snigdha Tiash! cell.com/cell-metabolis…

2/ We used systematic, parallel CRISPR-based genetic screens in hepatocytes, run across multiple metabolic conditions, to identify regulators of lipid droplet biology. You can access these screens through crisprlipid.org.

Instead of starting with a disease and searching for a drug…we started with a therapy (individual vitamin) and asked: which genetic diseases might they rescue? Essentially a new flavor of nutrigenomics.

1/ Thrilled to share our new paper in @Nature: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” From our lab together with @apsarruda, led by co–first authors @alymathiowetz and @EmilyMeymand. 🥳 nature.com/articles/s4158…

Our paper on The Lipid Interactome is now published, and the database is open: lnkd.in/g-swyT2a Why you should care: Lipid–protein interactome studies are exploding, but the data is scattered across papers, inconsistent formats, and silos making it hard to compare/reuse.

Read my latest #research on #fat #metabolism and #thermogenesis, published with @SpringerNature in @NatMetabolism rdcu.be/e5gLi

Out in final form: tinyurl.com/5fe33xp3 RBCs are a surprising glucose sink in hypoxia! New nuggets and collabs w/ D'Alessandro/Doctor labs: (1) RBCs "born in hypoxia" are different and (2) visualizing a O2-dep. glycolytic metabolon! Join us @arcinstitute @GladstoneInst!

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

Anddd...we are hiring a joint postdoc btwn Jain and Goodarzi labs to continue on the intersection of nutrient metabolism + cancer! Message @genophoria or me! fun times ahead @arcinstitute ...

A huge team effort and joint project with @genophoria (Hani Goodarzi's) lab -- we show that systemic hypoxia (and our hypoxia drug, HypoxyStat) suppress tumor growth! @arcinstitute @GladstoneInst @UCSF led by rockstars (@AyushDMidha, Brandon Chew, @Choi_Benedict, Timmy, Chris!)

@TheTafesseLab @OHSUNews Congratulations!!!

Big career update:  I’m honored and humbled to serve as Chair of the Department of Molecular Microbiology & Immunology at Oregon Health & Science University (OHSU). Looking forward to what we’ll build together! @OHSUNews

STING drives inflammation and aging pathology. Today, @Nature, we show that PI(3,5)P₂ is an endogenous ligand that cooperates with cGAMP to trigger STING activation — revealing a new nexus for disease intervention. Here is the PDF rdcu.be/e2lVI

Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism dlvr.it/TQkbdP

Excited to share our new preprint in collaboration with Paul Cohen's lab at Rockefeller University and Ken Loh's lab at Yale University! We introduce TurboID-TMT for cell type-specific proximity labeling to profile organ secretomes and ER-resident proteomes in vivo.

Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure | Science science.org/doi/10.1126/sc…

Out today 🙌 new work from the lab in which we show that p53-driven senescence enables phospholipid headgroup recycling to help sustain the increased synthesis of membrane phospholipids of senescent cells #Abs1" target="_blank" rel="nofollow noopener">nature.com/articles/s4155…

For nearly a century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @NatMetabolism, led by @thebioKIMist! Leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q 🧵