Jess Davidson

Excited to share our latest story on the regulation of lysosomal BMP lipids! Co-led with Raghav Jain, we show that PLA2G15 is a BMP hydrolase that regulates lipid levels under the transcriptional control of TFEB. @JudithSimcox @UWBiochem @HHMINEWS

Officially tenured. Thank you to all the mentors who guided me, and to the trainees who made this possible with your ideas, hard work, and scientific joy.

Great work by Mugagga, @LainyVonBank and @_JessDavidson from the Simcox Lab! SCD1 is known to regulate the production of monounsaturated fatty acids and development of diabetes in response of high carbohydrate diet. We showed loss of SCD1 also controls acylcarnitine levels.

As promised, a 🧵 on our recent article now out in @NatureSMB! Co-led with @AbbyBartlett_ @Pagliarini_Lab @JudithSimcox, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯#lipidtime doi.org/10.1038/s41594…

AHH!! My primary thesis work is finally out! Tweetorial to come...

30 mile ride to celebrate 30 weeks of pregnancy 💪🏼 pretty stoked with how this cell culture experiment is going so far!

Congratulations to Dr. Andrea Hunger on receiving the WISL Award for Communicating PhD Research to the Public! Dr. Hunger's thesis chapter explores novel genetic regulators of metabolism. scifun.org/Thesis_Awards/…

My lab is recruiting a postdoc fellow to characterize new biochemical pathways that control taurine and glucose metabolism. Email me at wei.wei2@wisc.edu to apply! Please help RT🙏 @longlabstanford @JudithSimcox @UWBiochem

@YutongBao @JudithSimcox @UWBiochem @HHMINEWS Thanks, Yutong!

@_JessDavidson @JudithSimcox @UWBiochem @HHMINEWS Congratulations Jess!!

Excited to share our latest story on the regulation of lysosomal BMP lipids! Co-led with Raghav Jain, we show that PLA2G15 is a BMP hydrolase that regulates lipid levels under the transcriptional control of TFEB. @JudithSimcox @UWBiochem @HHMINEWS

@WeiWei_Stanford @JudithSimcox @UWBiochem @HHMINEWS Thank you!!

@_JessDavidson @JudithSimcox @UWBiochem @HHMINEWS Congratulations!

5/ There are still many unanswered questions on PLA2G15 post-translational regulation and stereoisomer specificity for BMPs to be explored in the future. But this is a huge step forward for the field and I’m thrilled to be a part of such impactful, collaborative research.

4/ This is exciting, as PLA2G15 was identified as a BMP lipid hydrolase not only by us but also in recent work from our collaborators in the @abu_remaileh lab who further characterized PLA2G15 as a potential therapeutic target in NPC disease.

Stoked for the opportunity to share some of my translational research with the Biochemistry community at the University of Utah next week!

Please join us on May 19 for Andrea Hunger's Ph.D. thesis defense! Hunger's research in the @JudithSimcox Lab examined the regulation of a lipid that controls cell death and insulin signaling. Learn more: ipib.wisc.edu/2025/04/23/ipi…

Join us for Gina Wade's Ph.D. thesis defense on May 2! @JustWadeAMinute's research in the @JudithSimcox Lab examined the role lipids play in regulating body temperature during cold exposure. Learn more: ipib.wisc.edu/2025/04/18/ipi…

I'm beyond thrilled to announce that I will be joining the Biochemistry Department at the University of Wisconsin–Madison this fall as an Assistant Professor. My lab will focus on deorphanizing biochemical pathways that regulate nutrient metabolism @UWBiochem @uwmadisonipib

Excited to share that work from my PhD thesis is now available in @NatMetabolism! Here, we uncover a link between heme production, BCAA metabolism, and thermogenesis—implicating heme synthesis in #aging, #obesity, and #T2D. Link: nature.com/articles/s4225… A 🧵 (1/14)