Sheldon Rowan

Please enjoy the latest publication from our lab "Restriction of Individual Branched-Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice"

@LammingLab Awesome study! I also really appreciate the insights this work has in sex differences!

Malia Edwards et al from Wilmer Eye Institute @HopkinsMedicine describe choroidal vascular findings in a case of multifocal geographic atrophy using histology & immunohistochemistry & correlating the findings with multimodal clinical imaging @AMD_histo_lab doi.org/10.1167/iovs.6…

We are excited to share that our team's paper is published in Immunity: "Resident tissue macrophages maintain intraocular pressure homeostasis." This work grew out of a collaboration between glaucoma clinician-scientist Katy Liu MD PhD, glaucoma physiologist W. Daniel Stamer PhD, and immunologist Daniel Saban PhD, bringing together clinical, physiological, and immunological expertise to tackle a long-standing question: does the immune system directly regulate intraocular pressure? The answer is yes. authors.elsevier.com/a/1mkeB3qNrV3V… #Glaucoma #Immunology #ResidentMacrophages #Ophthalmology #Immunity #CellPress cell.com/immunity/fullt…

"A daily multivitamin slows biological aging." That's the headline from a new Nature Medicine paper. From a randomized trial! But when you actually read the data, the vitamin is doing just about nothing. Thread.

@EricTopol If anybody is wondering about omega-3 supplements for prevention of cardiovascular disease, the NIH has an amazing summary about this. Eric is 100% correct, but something to think about for those that do not eat fish or seafood. ods.od.nih.gov/factsheets/Ome…

Q—What supplement should you take for heart health? A—None washingtonpost.com/wellness/2026/… "The American Heart Association concluded that there is not enough evidence to support the use of any supplements to prevent cardiovascular disease." “There are no adequate data that support cardiovascular benefit for supplements in healthy people who eat a healthy diet" (—me)

Hi Friends! Did you hear about STAT Madness? Not enough space to explain now😀, but check it there: statnews.com/feature/stat-m… and VOTE for DSK lab! We’re competing with a project studying how lipid supplementation may improve aging vision. Thank you for your support!!! #aging #AMD

@DrDorotaSK Dorota, you totally have my support. And that's a tough first round match against my colleague at Tufts University!

Excited to share our new manuscript from the Yoshimatsu and MacDonald labs. biorxiv.org/content/10.648…. We found that my favourite glial cells can regulate local retinoic acid signalling to specialise cone photoreceptors for high acuity vision.

New @NatureMedicine A randomized trial of antibody vs activin type II receptors with or without semaglutide (Ozempic). The antibody, bimagrumab, promotes muscle growth. Marked weight loss with the combination nature.com/articles/s4159…

@YoniFreedhoff Yes, yes. But... If you look at the fat/protein content, it should pretty effectively counteract the high glycemic index of the corn starch. If it's an improvement on the original and people were going to eat it anyway... Also has lower sodium.

Don't know if they are, but I am at least

Over a decade ago, BrightFocus Foundation grant recipient, Dr. Ilyas Washington acted on an unconventional hunch that enriched vitamin A could stop toxic buildup in the eye, a hallmark of macular degeneration. His research led to an oral pill that is now in clinical trials showing promise for slowing vision loss in rare and age-related forms of macular degeneration. Early-stage research funding is how we turn scientific hunches into breakthroughs that preserve sight. Explore the research. ↘️ brightfocus.org/news/early-res…

Below is the story of the first patient treated with a prime-edited therapeutic, developed by @PrimeMedicine in a trial led by Dr. Élie Haddad and his team at CHU Sainte-Justine. This teenager suffered from chronic granulomatous disease (CGD), an immunodeficiency, and now—10 months after treatment—the patient is healthy, stable, and living with a functioning immune system. Tracy Attebury, whose story was previously told by @ginakolata @nytimes, was the second patient treated with a prime-edited therapeutic. cihr-irsc.gc.ca/e/54638.html

We are pleased to announce that RPB awardee Maria Grant, MD, of @UofAlabama at Birmingham, and her colleague, Seth Fortmann, MD, PhD, have been recognized for their discovery of immune cells that protect against age‑related macular degeneration. bit.ly/4tJOuLf

New #NIHFunded study finds a sex-specific vulnerability in retinal aging. Disrupted cell signaling and energy use drove retinal nerve loss in aging female mice, pointing to new targets for #Glaucoma and related diseases. @VUMCDiscoveries @SciReports: go.nature.com/4ttLouE

Rods & cones don’t play by the same metabolic rules. #NIHFunded work shows rods rely on glucose transport across the outer blood-retinal barrier, but cones are more resilient. @JeffersonUniv @UMKelloggEye @iScience_CP paper: bit.ly/4rqxWpv

Large biobank analysis suggests many disease-risk modifying variants linked to inherited retinal degeneration have lower population penetrance than assumed. #NIHFunded findings inform how we interpret genetic risk. @MassEyeAndEar @HMSEye @AJHGNews: bit.ly/4qjXDaC

First test of partial epigenetic reprogramming to reverse aging for two eye conditions (glaucoma and NAION) gets FDA go ahead @lifebiosciences Based on 2020 @Nature paper pubmed.ncbi.nlm.nih.gov/33268865/ endpoints.news/exclusive-fda-…

Shout-out to the excellent analysis from @broademily

Fascinating article about the lawsuits against food manufacturers. I think these are doomed to fail because of poor definitions of UPFs and insufficient clinical evidence of their direct harm - the same reasons the DGAC did not directly address them.hls.harvard.edu/today/the-new-…