Sixt Lab

We are really happy to see @mehmetintheory, @zanealsberga and @jonna_alanko‘s work on self generated gradients in collective migration out! Another great collaboration with @EdouardHannezo ‘s lab. Check the pre-print 👉 tinyurl.com/36dsz47z

The Image & Optics Facility @ISTAustria is expanding it’s image analysis services and has a vacant position for a service oriented *Image Analysis Specialist* with a strong interest for data infrastructure organization🔬🧑‍💻📈 ista.ac.at/en/job/?title=…

If you would like to help science become more sustainable: • Reuse gloves when possible, they can be sterilized with no change in their properties: 📄twtr.to/uPYLx • Don't overstock-gloves do expire!

An institute like ISTA consumes around 1700 gloves/day. These gloves are often discarded after a single use. Although nitrile CAN be recycled, Europe lacks sufficient infrastructure to process this material, so the gloves end up being incinerated.

We teamed up with @ISTAsustainable and Saki, visiting artist @ISTAustria, and collected used non-contaminated gloves. The result was a beautiful dress worth a red carpet event in the lab. Check more of her work 👉sakitheartist.com 📸juergenhofmann.com

Last Friday our @ERC_Research synergy team #pushingcell got together @institut_curie in Paris. Great discussion with @BassereauTeam, @PierreSens group and Anna Akhamnova’s team!

👻Trick or treat?🎃 Here is a treat 🍬 In our new perspective article @mi_riedl dives into the self-organizing principles behind actin polymerization and the Belousov-Zhabotinsky reaction. Two seemingly different systems, one underlying principle. 👉 shorturl.at/hyUY3

@mi_riedl paper is officially out in @NatureComms! We show that actin wave synchronization unifies the speed in collectively moving cells. Our unconventional "toy" model emphasizes the importance of nearest-neighbor coupling in this process. Check it here: rdcu.be/dl0JF

(6/6)You can read more about it here: science.org/doi/10.1126/sc… Congratulations to all the authors involved!!

(5/6) DCs don't just passively follow chemical cues! CCR7 senses CCL19 and actively shapes the distribution of chemokine. This dual function allows immune cells to generate their own gradients, guiding their collective migration in complex environments more effectively.

🧵(1/6) How do immune cells know where to go? It has been proposed that cells simply respond to externally established gradients of chemokines, but we think that’s not all…

If you are attending the @lindaunobel Laureate Meeting this month you might meet our postdoc Mario (@mj_avellaneda)! We are all looking forward to hear about all the amazing talks that will happen…

Here is a peek at some bits from the story, a video with the images from @christlet and some of his comments, and a podcast with @Sixt_Lab @RolandSoldner protocolsmethods.springernature.com/posts/cytoskel…

The directed cell migration GRC is happening next January and there are still some places available! Don’t miss out on an interactive and engaging meeting. Find out more here: grc.org/directed-cell-…

📣 JOB ALERT!! 🔬 Time to get into the details of amoeboid #collectivemigration! 3 years funded postdoc position in collaboration with @PielMatthieu, @mcoppey and Voituriez labs to decrypt the cellular and molecular mechanisms of CAM (science.org/doi/10.1126/sc…)

@reenak52086225 @globalimmuno And maybe ezrin surrounds the spot and keeps it confined? We do not know why it is always spots of WASP and never bigger areas. Let's find out!

@globalimmuno @Sixt_Lab Wonderful talk, Michael! Just a quick thought that, if WASP is coupled to membrane deformation, would you think that a crosslinker 'ezrin' (for example) would have a crucial role in this context of cell migration and sensing the environment?

Please ask questions for today's Global Immunotalk by Dr. Michael Sixt HERE by replying to this tweet. Don't forget to mention #globalimmuno. Michael will use the account @Sixt_Lab to answer questions.