Train2Target

Interested in #drugdiscovery #pathogenesis and #Acinetobacter baumannii? Have a look at our OmpR-targeted anti-virulence drug development approach. Great collaborative effort @Bioversys @biozentrum @psich_en @aptuit @_BioSystems @Train2Target tandfonline.com/doi/full/10.10…

Happy to announce this new publication about mNeonGreen 💚 and sfTq2ox 💙 expression in the cytoplasm of E. coli. Congratulations to the authors @TannekedenBlaau and @LaureenMertens from @SILS_UvA ! doi.org/10.1038/s41598…

We are proud to share the latest @train2target paper from our #ESR Federico Corona In this paper, the authors explore the crosstalk between #OMP biogenesis and #peptidoglycan maturation Congratulations to al the authors!! Vollmer lab @KleanthousLab nature.com/articles/s4158…

The peptidoglycan of Akkermansia contains non-acetylated glucosamine (GlcNH2) which has not been described as a major component of gram-negative PG before! It activates NOD1 & NOD2 receptors leading to a similar immune response as to E. coli.

Happy to share another @Train2Target paper! In this paper, the authors challenge the hypothesis of how #peptidoglycan triggers the #immunesystem. Congratulations to all the authors! 👏 @PilarGVello @HanneTytgat @MolinaroTony @cribilla68 @UninaIT @WUR doi.org/10.1093/glycob…

We are proud of @Train2Target's Carina Matias (@CarinaSofiaM) contributions to this paper! The paper explores the potential of topical niclosamide ATx201 as a decolonizing agent. Congratulations to all the authors 👏👏 doi.org/10.1002/ctm2.7…

We're very happy to showcase this work by @Train2Target's Elisa Consoli, @TannekedenBlaau'wen and their collaborator Joen Luirink. 👏👏👏 'The Escherichia coli Outer Membrane β-Barrel Assembly Machinery (BAM) Crosstalks with the Divisome.' doi.org/10.3390/ijms22…

Proud to share this publication by @Train2Target ESRs @TiagoBaeta7, Elisabete Moura and their colleagues. The lipopolysaccharide transporter complex LptB2FG also displays adenylate kinase activity in vitro dependent on binding partners LptC/LptA doi.org/10.1016/j.jbc.…

Lipopolysaccharide lipid A: a promising molecule for new immunity-based therapies and antibiotics 🦠🔬 Always thanks to @MolinaroTony @cribilla68 @di_flaviana #AMR #vaccination #microbiome #diabetes #inflammation #ScienceReview #ScienceTwitter #Science #ab0005" target="_blank" rel="nofollow noopener">sciencedirect.com/science/articl…

Oral admin of pasteurised Akkermansia muciniphila is safe, the European Authority of Food Safety @EFSA_EU said! This is a crucial step towards new generation nutritional supplements to treat #diabetes and other metabolic diseases. It's also part of my PhD! efsa.europa.eu/en/efsajournal…

We are happy to announce this paper from @Train2Target ESR @JessicaelRayes1 and her colleagues. Congratulations to all the authors! 🥳 'Disorder is a critical component of lipoprotein sorting in Gram-negative bacteria.' nature.com/articles/s4158…

Happy to announce our last paper: how disorder controls lipoprotein targeting. Congrats @JessicaelRayes1 queen of the ultracentrifuge :) beautiful work, journey with @MichaelDeghelt @IorgaBI @bluegreen812 @NaemiC thanks @Welbio_asbl @UCLouvain_be @frsFNRS nature.com/articles/s4158…

Happy to share this preprint on @biorxiv_micrbio: 'LptB2FG is an ABC transporter with Adenylate Kinase activity regulated by LptC/A recruitment.' A collaboration between our ESRs @TiagoBaeta7, Elisabete Moura and their colleagues in Grenoble and Milan. biorxiv.org/content/10.110…

Congratulations Raquel ! You have done a terrific work Dr Rodriguez Alonso ! We were all impressed by the high level discussion you had with the jury members. Good luck with your next step ! We will miss you. Thank you to @Train2Target

Meet our newest @Train2Target Doctor @RaquelRguezAl! Raquel publicly defended her PhD thesis on Friday. Congratulations! 🥳🍾🎉

Congratulations to new the Dr. @MitjaMZ on successfully defending his PhD thesis last week 🥳🎉 Congratulations Mitja 🖖

Very happy to announce this new publication involving work by @Train2Target's Federico Corona and Prof. Waldemar Vollmer. Combining Cell Envelope Stress Reporter Assays in a Screening Approach to Identify BAM Complex Inhibitors doi.org/10.1021/acsinf…

Congratulations to @Train2Target and @AiCuris researcher @AranchaLopezPe1 for successfully defending her PhD thesis 'A target-based approach to identify scaffolds for developing novel PBP inhibitors' at Newcastle University! 💐👏💐👏💐👏💐

@Train2Target Why do I look like a giant?!

That was it! We had a good time in Grenoble and are all going back to our homes-away-from-home! Here's the group pictures :)

Very happy to announce this publication by @AranchaLopezPe1 and colleagues in @antibioticsmdpi Discovery of Pyrrolidine-2,3-diones as Novel Inhibitors of P. aeruginosa PBP3. doi.org/10.3390/antibi…