Hawthorn ✶

Conversion Pathways to DHT : Testosterone → DHT (via 5α-reductase, 5AR) ────────── Androstenedione (A4) pathways : Androstenedione → 5α-androstanedione → DHT (via 5AR, then HSD17B3 / AKR1C3) Androstenedione → Testosterone → DHT (via HSD17B3 / AKR1C3, then 5AR) ────────── 11-oxygenated androgen pathways : Testosterone → 11β-hydroxytestosterone → 11β-hydroxy-DHT → 11-keto-DHT (via CYP11B1/2 → 5AR → HSD11B2) Testosterone → 11β-hydroxytestosterone → 11-ketotestosterone → 11-keto-DHT (via CYP11B1/2 → HSD11B2 → 5AR) Androstenedione → 11β-hydroxyandrostenedione → 11β-hydroxytestosterone → 11β-hydroxy-DHT → 11-keto-DHT (via CYP11B1 → HSD17B3 / AKR1C3 → 5AR → HSD11B2) Androstenedione → 11β-hydroxyandrostenedione → 11β-hydroxy-5α-dione → 11-keto-5α-dione → 11-keto-DHT (via CYP11B1 → 5AR → HSD11B2 → HSD17B3 / AKR1C3) ────────── Backdoor / progesterone-derived pathways : Allopregnanolone → Allopregnanolone-diol → Androsterone → Androstanediol or 5α-androstanedione → DHT (via CYP17A1 → HSD17B3) 17α-hydroxyprogesterone → Androstenedione → 5α-androstenedione → DHT (via CYP17A1 → 5AR → HSD17B3) 17α-hydroxyprogesterone → Androstenedione → Testosterone → DHT (via CYP17A1 → HSD17B3 / AKR1C3 → 5AR) ────────── Reversible / interconversion pathways : 3α-androstanediol → DHT (via HSD17B6, HSD17B10, RDH4, RDH5, 3α-HSD) 3α-androstanediol → Androsterone → 5α-androstanedione → DHT Androsterone → 3α-androstanediol → DHT Androsterone → 5α-androstanedione → DHT

@thebeautyofsaas Decentralizing your life is a must. Few understand this.

you want multiple passports, bases of operations in different geo locations and the ability to relocate yourself wherever necessary. boomers are getting bored and the next few years will bring mass uncertainty and hysteria. the pattern is becoming more obvious as time goes on

the world belongs to the energetic

The man who controls his mornings controls his life

The nicest weather in the USA today will occur between St Louis, MO & Chicago, IL

how an armodafinil and a triple espresso look at me at 8am on a tuesday

I don't want a perfect life. I just want a free one.

show up like God sent you.

@celestialbe1ng cypro has such utility. I take it for the dopamine rebound. mid-day dose + eat a big meal, go to sleep early, wake up feeling a euphoric calm. don't overdose it, don't take multiple days in a row. take when you need a reset

I know that Dr Peat spoke about the face-lift effects of pregnenolone, but to me cyproheptadine does this best. Can go from tired, old looking and sagging “hamster face” to a refreshed face-lift effect in two (2!) doses. At this point I doubt there’s anything cypro can’t do. All for pennies a dose lol Mechanism: strong serotonin + histamine antagonism → ↓ inflammation & vascular permeability, ↓ cortisol → rapid de-puffing, tighter facial tone, more energised and alert look (kills “serotonin eyes/face”) Incredible

@celestialbe1ng Interestingly, at most serotonin receptors cyproheptine interacts with its not a antagonist but a inverse agonist so it doesn’t just block the receptor it actively makes the receptor function below baseline.

Oxandrolone (Anavar) is often cited with an anabolic-to-androgenic ratio around 322–630 : 24, with testosterone set at 100 : 100. On paper, that translates to roughly 3× to 6× more anabolic per mg than testosterone, with much lower androgenic signaling. It does not aromatize, so estrogen-related effects are limited. This removes one pathway of suppression. The second factor is its relatively low androgenicity, meaning weaker androgen receptor–mediated negative feedback compared to more androgenic compounds. In clinical settings, doses around ~20 mg/day have shown minimal suppression in some contexts, which aligns with both the lack of aromatization and its lower androgenic signaling. It also has anti-catabolic effects through glucocorticoid receptor antagonism, which is one reason it has been used in burn patients, HIV-related wasting, and post-surgical recovery. Reported effects include improved nitrogen retention, preservation of lean mass, increases in strength without significant water retention, and a lower incidence of androgenic side effects compared to many other anabolic steroids. It remains a 17α-alkylated oral compound, so hepatotoxicity is present. At lower doses it is generally considered manageable, but risk increases with dose and duration. There is a consistent gap between older reports describing it as effective and newer reports describing little effect. A major factor is product authenticity. Oxandrolone is frequently substituted with compounds like stanozolol, turinabol, or methandrostenolone, which leads to different outcomes. Pharmaceutical-grade oxandrolone is limited. Iranian pharmaceutical products have been among the known legitimate sources in certain periods. I was able to obtain Iranian oxandrolone before the war. Would you want a detailed breakdown of that experience?

This Peptide app got released 4 days ago and already at $10k MRR 🫠🫠🫠 Right now it's #3 fastest growing NEW app in the world.

Some shots from Supermoon 🌑

Matthew McConaughey wearing his same leather jacket from the 90s

Male pheromones : Androsterone : helps wearers seem more trustworthy, appear more masculine, and project “solid protector” vibes. Androstenone : contains some of the most potent molecules for sexual attraction. Increases sexual desire in women and signals you are a potential mate or sexual partner. Androstadienone : creates feelings of comfort and intimacy. Common in men’s long-term bonding phase. Known to improve mood in women and even help PMS symptoms. Androstenol : makes the wearer appear approachable, friendly, and outgoing. Minimizes awkwardness and makes women more likely to initiate conversation. Female pheromones : Copulins : associated with female fertility signals. Can increase male testosterone levels, boost sexual interest, and make men perceive women as more attractive. Signals peak fertility and reproductive readiness. Estratetraenol : linked to feminine signaling. Can influence male perception of women’s attractiveness and softness. Thought to enhance emotional connection and subtly shift male behavior toward bonding and attention.

Yes Instagram, please keep feeding me Masters foids #would

Pacific Beach San Diego is probably top five places to live on the planet

Oysties on the go instead of just zinc. Freeze drying retains 90-99% of nutrients. The full food matrix. That’s also why we chose freeze dried fruits instead of dehydrated powders, or lame “flavors”.