Dafne Durón

Among individuals with severe, treatment-resistant #Schizophrenia, #dementia was common and showed a distinct clinical and genetic profile not explained by #Alzheimer disease, cardiovascular risk, or medication effects. ja.ma/4uWAsGG

Aging clocks may be shaped by neurosyndemics, multiple interacting physical and social real-world environments jointly influencing brain health. Out in Nature Medicine (nature.com/articles/s4159…), we assessed 18,701 participants from 34 countries, showing that the combined aggregate-level exposome (73 physical, social, and political factors measured at country-level) predicts multimodal brain aging far better than isolated exposures (up to 15-fold more variance). Moving beyond single risks, we provide evidence that synergistic, nonlinear exposome burden accelerates brain clocks across health and disease, with physical exposures linking more strongly to structural brain aging and social exposures to functional brain aging. Exposome burden increased the risk of accelerated brain aging by 3.3–9.1-fold, in some cases exceeding the effects associated with dementia, and these findings held in out-of-sample, longitudinal, individual-level variation, and sensitivity analyses. Thus, the pace at which the brain ages may be shaped by syndemic environmental and societal conditions, calling for much more intersectoral policies. Congrats @AgustinaLegaz Sebastian Moguilner @HernHdezL & all coauthors. 1/5👇 @GBHI_Fellows

🎙️Check out the final podcast in our new series on dementia! IN THIS EPISODE, we rejoin our patient BREDA COMISKEY. Despite having Alzheimer’s, Breda is living life to the full. bit.ly/4pxLdvl #themanyfacesofalzheimer's #TUHdementiaawareness

The @UN declaration on noncommunicable diseases (NCDs) has explicitly included dementia. At @LancetGH we discuss how countries can take real action to prevent dementia when it is treated like other major diseases. Preventing dementia needs to go beyond individual choices, with coordinated actions to improve education, health systems and living conditions. Led by @SimoneSalemmeMD & @seb_walsh. #PLADRR.  thelancet.com/journals/lanpu…

FDG-PET effectively differentiates vegetative state from minimally conscious state in chronic patients, although its diagnostic accuracy can be affected by etiology. Read at 👉 buff.ly/VSrkGGw @NeuroBesta

La adaptación del sistema de salud para responder a las necesidades de las personas mayores de manera accesible, oportuna y con calidad es un reto enorme para el que no existe una única solución. Documento completo ➡️ bit.ly/4cln2JT

🎓☂️ Sesión CONAMEGER ⛓️ Envejecer tras las rejas 👩‍⚕️ Natalia Sánchez Garrido 📅 26 marzo 🕗 20:00 CDMX 👉 us06web.zoom.us/j/83502079829?… 🆔 83502079829 🔑 036498 ☂️ Mesa Directiva y Comité Académico CONAMEGER 2024–2026

🎵 What if the mind works like a piece of music? A new study proposes music as a scientific metaphor to explain the brain’s dynamic processes, with contributions from researchers involved in @ReDLat_Dementia doi.org/10.1016/j.neub…

Music helps to understand the mind and the brain. Throughout the history of science, metaphors have shaped how we understand complex phenomena. The brain-as-computer metaphor has guided decades of theories and research. We propose music as a scientific metaphor for understanding the mind and brain via triplicate interfaces (listener, performer, composer) and a compound set of predictions. Multiple domains of music can be mapped onto different neural, cognitive and intersubjective processes such as network coordination, prediction, emotion and meaning. Neurocognition is not static but a dynamic, embodied, and time-sensitive system, much like a self-organized orchestra in which multiple processes interact simultaneously. Drawing on synergetics, predictive processing, and embodied cognition, we outline musical principles illuminating cognitive and action integration across time, offering new conceptual frameworks and testable predictions for future research. I enjoyed writing this piece with these stellar authors: @Kaiameye, @acolverson1, Christopher Bailey, @brucemillerucsf, @dafneduron90, Nicholas Johnson, Olga Castaner, @PierLuigiSacco, Eoin Cotter and Lucia Melloni. Science, like music, advances through new ways of listening to complex systems: doi.org/10.1016/j.neub…

🎓☂️ Sesión CONAMEGER 🧠 Delirium: voces y desafíos 👩‍⚕️ Carolina Gómez Moreno 👨‍⚕️ Francisco Martínez Carrillo 📅 12 marzo 🕗 20:00 CDMX 👉 us06web.zoom.us/j/83502079829?… 🆔 83502079829 🔑 036498 #WDAD26 ☂️ Mesa Directiva y Comité Académico CONAMEGER 2024–2026

What is World Delirium Awareness Day? This annual event raises awareness about #delirium and its impact on patients, families, and healthcare systems. Learn more and find out how to get involved with #WDAD2026: deliriumday.com

🚨 NEW PUBLICATION 🚨 We present an up to date review of blood 🩸 biomarkers of #Alzheimer’s disease. Open access link: journals.lww.com/co-neurology/f…

Felicitamos a nuestra directora Claudia Durán-Aniotz por este reconocimiento a su trabajo en mentoría y formación en neurociencia, fortaleciendo la investigación en Alzheimer desde América Latina con impacto global. Conoce más sobre el premio aquí: brainlat.uai.cl/claudia-duran-…

Great review on therapeutic targeting of neuroimmune mechanisms in neurodegeneration @NatRevDrugDisc The review discusses the role of the central and peripheral immune systems in neurodegeneration. These insights could help redirect future drug discovery efforts toward immune targets that complement existing therapies aimed at core pathological features. nature.com/articles/s4157…

🔬 Curious about biomarkers and what they mean for FTD? Learn how biomarkers help improve diagnosis, guide treatment, and advance research in FTD. Join AFTD, the @EndFTDregistry, and Dr. Charlotte Teunissen for a free webinar on March 10 at 10 am ET that breaks it all down. 🔴 Sponsored by @AviadoBio 👉 Register now: bit.ly/45RGKg5

☂️ Sesión Académica CONAMEGER 🩺 VIH en personas mayores 👩‍⚕️ Dra. Brenda Crabtree 👩‍⚕️ Dra. Yanink Caro 📅 19 febrero 🕗 20:00 h CDMX 💻 En línea | 🎓 Gratuita 📄 Constancia con puntos 👉 Únete aquí: us06web.zoom.us/j/83502079829?… ☂️🌍 Comunidad CONAMEGER

📄NEW PUBLICATION | "Blood-based AT(N) biomarkers for Alzheimer’s disease and frontotemporal lobar degeneration in Latin America" in Nature Aging with the participation of some @LACCD9 members. Access the paper here 👉 doi.org/10.1038/s43587…

Hospitalized PD patient with sudden rigidity, confusion, or fever? Think acute dopamine depletion. In this Mayo series, triggers included levodopa withdrawal (27%), antidopaminergics (33%), sepsis ± withdrawal (34%), and DBS failure. Remember: • Never interrupt levodopa • Avoid antidopaminergics • Always rule out sepsis loom.ly/bdYDTXw

@ConamegerMX QEPD

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Today we celebrate the International Day of Women and Girls in Science #Feb11, a @ONU_es initiative promoting equal access and participation in science. At @BrainlatUAI, we support diversity and inclusion to advance brain health in Latin America. 🔬✨ #WomenInScienceDay