Daniel Elías Martín Herranz

@MarioniGroup @unibirmingham @hurdlebio @Bayer @Tulane @lisalyliton We hope to make the clock available soon in the #biolearn package in collaboration with the amazing team from @agingbiomarkers 🧬

Thanks to all our collaborators from @MarioniGroup @unibirmingham @hurdlebio @Bayer @Tulane and to the incredible @lisalyliton for getting her first epigenetic clock out in the wild 😊

📣 New paper alert! #Inflammage, our new epigenetic clock for systemic chronic #inflammation (SCI) has been published in the leading journal Aging Cell. onlinelibrary.wiley.com/doi/10.1111/ac… 🧬 A few bullets on the significance of this paper (starting thread):

@AlbertVilella Thanks for sharing @AlbertVilella ! Agreed that saliva as a tissue type is such an exciting area for research in non-invasive biomarkers!

Saliva is one of the 'there be dragons' areas when it comes to the challenges, mysteries, or uncertainties yet to be uncovered. A novel framework to build saliva-based DNA #methylation biomarkers: quantifying systemic chronic #inflammation as a case study biorxiv.org/content/10.110…

Thanks for sharing! Looking forwards to further validate InflammAge and make it part of the suite of @agingbiomarkers at our disposal for research and clinical trials.

1/5 👅 Co-authored by Contributor Riccardo Marioni (@MarioniGroup), this recent preprint describes a novel framework for saliva-based DNA methylation biomarkers. Leveraging blood DNAm data and EpiScores, InflammAge is introduced, a clock quantifying systemic chronic inflammation.

If you are interested in #ageing and #DNAmethylation biomarkers, have a look at our latest work on how to measure chronic inflammation from saliva. Amazing collaboration with @MarioniGroup @bayerconsumer @Lord_Lab!

Super excited to share our preprint on inferring biomarker signatures across 3,308 binary traits from @uk_biobank leveraging 67 quantitative traits with #MILTON & boosting PheWAS signals. medrxiv.org/content/10.110…

@dimvitsios @uk_biobank Amazing work @dimvitsios ! Do you get disease predictors with common Biomarkers that could be leveraged for preventative healthcare better than current methods / goldstandard diagnostics?

@DevilsAdvoMax @rfschwarz @DrewsRM @HaaseKerstin @gjmacintyre @imartincorena @MoritzGerstung @fran_mj88 @Carolinmsa @VeroMiro1 @BenjaminWerner_ @gcaravagna PDGFRA and PDGFRB still in the game! Always great to see hypotheses standing the pass of time and data from Master’s times. Many congrats for this fantastic piece of cancer evolution! 🎉👹

Both lineages evolve neutrally (global dN/dS ~1) 😐 We also traced the high-resolution copy-number phylogeny for DFT1 and DFT2 – empowered by the recent MEDICC2 @rfschwarz. CNV landscapes are flat 🥞, but a few selected genes (PDGFRB, PDGFRA) are repeatedly amplified. ↗️ 10/n

NOW OUT @ScienceMagazine 🧬🐾🤓 “The evolution of two transmissible cancers in Tasmanian devils” A 🧵 on our deep DNA sequencing dive into the startling genetic history of contagious tumours (1/n) 👇 doi.org/10.1126/scienc…

The first experiment of the Mosteiro lab! So excited to start my lab with these amazing scientists and looking forward to the adventures ahead! 🔬🧬🧫🥼👩🏽‍🔬

New pre-print alert 🚨 @franci_tag shows that DNMT3B PWWP mutations cause hypermethylation of H3K9me3 heterochromatin that is facilitated by its N-terminus. You can read more here: biorxiv.org/content/10.110… But here is a quick summary 🧵 1/10