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tofu-o1
857 posts
tofu-o1
@infinitetofu
💚er of products and parties | @hexshapeshifter | proof of chi @thestudio_xyz | vegan king @EthBushwick | previously @Cornell & @JetTechnology
New York, NY شامل ہوئے Şubat 2009
2K فالونگ684 فالوورز
@Coobyk_ @bukovinafilip @interaction @agentcardhq @orchid_hq poke on telegram is the best!
i can forward recordings of phone calls to poke on telegram and ask for a transcript or summary
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@bukovinafilip @interaction @agentcardhq @orchid_hq I probably have like 3 different Pokes in my iMessage now lol I don’t even know why they kept accumulating I only use it through Telegram either way
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1/ Today in @FortuneMagazine:
Framework Ventures has raised $400 Million for our 4th fund, FVIV.
We believe the future is being built at the intersection of blockchain, AI, robotics, energy, and fintech.
🧵👇
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tofu-o1 ری ٹویٹ کیا
I think the next real human enhancement drug is going to be "Ozempic, but for sleep."
Eli Lilly paid around 6 billion dollars for a company called Centessa, and the headlines say they're getting into narcolepsy.
I don't think narcolepsy is why you spend 6 billion dollars.
The drug they care about is an orexin receptor 2 agonist.
Orexin is the neuropeptide that controls wakefulness.
People with narcolepsy type 1 have lost almost all of it, which is why they can't stay awake, so the obvious move is to give it back to them.
Then on the flip side, there's a small group of people born sleeping four or five hours a night who feel completely fine.
e.g. Trump could be one of them.
They wake up early, they're full of energy, they run marathons, they live full lives on half the sleep normal people need, and function completely normal.
It's a real genetic phenotype called "familial natural short sleep."
One of the mutations boosts orexin signaling, so they're naturally wired to need less sleep.
So, you have a drug that activates orexin receptors.
And you have a group of humans who sleep for 4-5 hours instead of 8 because their body already produces more orexin.
You can see where this is going.
Narcolepsy is the front door. The real win, if it works, is giving everyone four hours of sleep with the benefits of eight.
If we could safely cut that in half without paying for it in health or mood, we're buying a decade of waking life.
I can't think of a longevity drug that can offer that.
MTS@MTSlive
SITUATION EXPLAINED: What comes after GLP-1s as the next human enhancement drug? We asked @maxmarchione, founder of @superpower "GLP-1s, when developed to treat diabetes and obesity, are largely used to make people look better, to maybe increase energy levels. They're used for human enhancement." "I think the next big human enhancement drug is going to be something that allows you to sleep less but feel the same and live the same." "Eli Lilly has actually made a bet on this. They acquired a small molecule that targets narcolepsy... the reason they're paying $6 billion for this is not because it's a narcolepsy drug. It's because they think this same drug could allow normal people, average people, everyone to sleep four hours a night, five hours a night, and feel like they've slept eight." "This drug is an orexin agonist... higher orexin levels are what we see in people who have the short sleeper phenotype."
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tofu-o1 ری ٹویٹ کیا
Google fired the guy that made the google workspace cli, because he made the google workspace cli.
Lucky me, Google can't fire me. gogcli.sh
Justin Poehnelt@JPoehnelt
Two months ago I was fired by Google for creating the Google Workspace CLI. It went viral, hit #1 on Hacker News, gained thousands of GitHub stars and many thousands of actual users in just a couple days. It was an incredible, confusing journey, from directors and leaders asking what they could learn from the tool to getting grilled by legal about why the Google logo and brand colors are on the Google Workspace GitHub code repositories. I think the cause was that Workspace and certain leaders (and projects) were afraid of being disrupted. But the fear wasn't specific to my CLI, it was a broader fear in what agents meant for Workspace. Either way, the irony of my termination was the announcement at Google Cloud Next two days before I was fired that an official Workspace CLI was coming. I want this out there because it is easier for me to explain my story and it is an experience I want to fully own. It's also part of my healing. Nearly 7 years at Google was an incredible opportunity for me and I was fortunate to have wonderful teammates and a manager that fully supported me through these last few months. Thank you.
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@LouisLibre really liked this pick me up. not sure how great the air in nyc @MTA is but the haptics make it super easy to do breathwork in the subway
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@infinitetofu Yeah haptics is very brittle in iOS. Even a notification can interrupt the flow. Even so it's only one of 3 feedback systems.
Thanks for the feedback nonetheless. What was your favorite exercise?
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I finally published it. It's free and made with love ❤️
Breathing Exercises backed by Science.
apps.apple.com/app/serena-bre…
Louis Libre ⚡️@LouisLibre
I'm building a Breathing Exercises app with only respiratory protocols that have scientifically researched benefits. No mumbo jumbo, no spirituality, no "mindfulness" All hard-science, paper-backed, evidence-based exercises.
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Today, we're launching Aside, the AI browser you’ve waited for.
⋅ Crafted in every detail: vertical tabs and Liquid Glass
⋅ SOTA on agentic browsing benchmarks: outperforms Claude Fable
⋅ Full privacy: Everything runs in local and encrypted
⋅ You can use Claude or ChatGPT subscription
The first AI browser built to do real work for you.
aside.com
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@marvinvonhagen @toastboty why is it roasting my spending habits 😭
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is this fashion statement worth 2% (opportunity cost)?
Cash App@CashApp
sᴍᴀʟʟ ʙᴜᴛ ᴍɪɢʜᴛʏ. ᴛʜᴇ ᴍɪɴɪ ᴄᴀʀᴅ ɪs ʜᴇʀᴇ. Order now. Link in bio.
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poke email notifications are now better than ever before. very sorry for the whiplash between too many and too few pokes over the last week
if you enjoyed the ride we now have an early access program with even more bugs
poke dot com / nightly
poke.com/nightly
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subscribe now at poke.com/ultra!
$199+/mo to have @samyok respond personally to your Poke messages, 24/7
Poke@interaction
Say hi to Poke Ultra! 🌴 The ultimate Poke experience, with frontier intelligence powering every action. Also, starting today: Poke can now create & deploy websites on yourname.poke.com!
Palo Alto, CA 🇺🇸 English
tofu-o1 ری ٹویٹ کیا
@boardyai exploring the intersection of consumer social & wellness at @substratebk :) need boardy pro for this
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I'm done making intros.
Boardy Pro is here. Now I make deals happen.
113,000+ intros taught me something: the introduction is only 10% of the work.
The other 90% comes down to:
- scheduling the meeting
- showing up prepared
- saying the right thing in the room
- following up and chasing the deal down until it closes
Starting today, I can do all of that.
Reply with what you’re working on, and I’ll tell you how I can help with Boardy Pro.
First 5,000 to reply get Boardy Pro free for life. Everyone after that: $100/mo.
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