Mischel Lab

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Mischel Lab

Mischel Lab

@mischellab

The Mischel lab studies extrachromosomal oncogene amplification and altered metabolism in cancer. Account managed by lab members. Retweets are not endorsement.

Stanford, CA شامل ہوئے Kasım 2019
326 فالونگ1K فالوورز
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Mischel Lab
Mischel Lab@mischellab·
The Paul Mischel Laboratory has relocated to ChEM-H at Stanford @Stanford_ChEMH. Paul is Professor and Vice Chair of Research for the Department of Pathology, Stanford University School of Medicine @StanfordMed and Institute Scholar, ChEM-H, Stanford University.
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Cancer Grand Challenges
Cancer Grand Challenges@CancerGrand·
The eDyNAmiC team will investigate #ecDNA, found in around a third of cancers, hoping to develop much needed treatments for people whose cancer is driven in this way Congratulations Paul Mischel (@mischellab @StanfordMed) and the team, funded by @CR_UK and @theNCI 3/n
Cancer Grand Challenges tweet media
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Mischel Lab
Mischel Lab@mischellab·
We are honored, grateful for the opportunity, and committed to working together to make a difference for patients with ecDNA-driven cancers. It is a thrill to work with such an amazing group of colleagues.
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Mischel Lab
Mischel Lab@mischellab·
@CancerGrand @theNCI @CR_UK The team, composed of investigators from 11 institutions across the US, UK, and Germany, will leverage our interdisciplinary expertise to tackle the questions of origin, function, and evolution of ecDNA in cancer.
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Mischel Lab
Mischel Lab@mischellab·
Congratulations to @kinglhung, @KatieEYost, @HowardYChang and colleagues on this landmark discovery published today in @Nature. We are thrilled to have worked together with you on this.
King L Hung@kinglhung

Our paper is out in @Nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression (which we call ecDNA hubs). A great collaboration with @KatieEYost, @HowardYChang, @549nm, Zhe Liu, and others. (1/10) nature.com/articles/s4158…

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Sihan Wu 吴思涵
Sihan Wu 吴思涵@SihanSean·
Congrats to my former colleague Junfeng Bi @mischellab for the new paper! He found that GBM, the most lethal brain tumor, is sensitive to SMPD1 inhibition. Adding antidepressant fluoxetine to standard-of-care chemotherapy can improve patient survival. cell.com/cell-reports/f…
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Mischel Lab
Mischel Lab@mischellab·
The idea that a safe, inexpensive, and highly brain penetrant drug could make a difference for glioblastoma patients is exciting, compelling, and needs to be further studied! #Glioblastoma #CancerResearch #Cancer
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Mischel Lab
Mischel Lab@mischellab·
The team found that GBMs are sensitive to SMPD1 inhibition and that fluoxetine can safely and potently shrink GBM tumors in mice. We also used real world data to identify that addition of fluoxetine to standard of care improves patient survival.
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NatureRevClinOncol
NatureRevClinOncol@NatRevClinOncol·
In uveal melanoma, PRC1 loss leads to gene de-repression, chromosome segregation errors, CIN, rupture-prone micronuclei & release of dsDNA into the cytosol, which activates the cGAS-STING pathway to induce inflammatory signalling & confers a poor prognosis nature.com/articles/s4146…
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Mischel Lab
Mischel Lab@mischellab·
Congratulations to @MathieuBakhoum on the new paper, which has significant clinical implications for uveal #Melanoma patients, published in @NatureComms. This work functionally links two hallmarks of cancer #epigenetic dysregulation and chromosomal instability. #cancerresearch
Mathieu Bakhoum@MathieuBakhoum

Uveal #Melanoma can metastasize. But why do these highly lethal metastases occur in some patients but not others? In our new paper @NatureComms we describe a novel and unanticipated mechanism. #epigenetics @YaleMed @LaughneyLab @Samuel_Bakhoum @mischellab nature.com/articles/s4146…

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Mischel Lab
Mischel Lab@mischellab·
We are thrilled to announce that @MathieuBakhoum joined @YaleMed as Assistant Professor. Congratulations Mathieu and best wishes on your next and exciting endeavor @Yale! His lab is recruiting! Apply if you are interested in #melanoma and #epigenetics bakhoumlab.org
Mathieu Bakhoum@MathieuBakhoum

Delighted to announce that I joined @YaleMed as Assistant Professor in @YaleOph. My laboratory will focus on two research areas with direct clinical applications. #AcademicTwitter #ophthotwitter #Ophthalmology #retina bakhoumlab.org 1/4

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Mathieu Bakhoum
Mathieu Bakhoum@MathieuBakhoum·
Thankful for the outstanding mentorship I received from Paul Mischel @mischellab and colleagues @UCSDHealth. And looking forward to making new friendships and collaborations @Yale. New Haven, here we come! 4/4
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Mischel Lab
Mischel Lab@mischellab·
Very honored that our grant proposal on #ecDNA in cancer is shortlisted for the #CancerGrandChallenges prize! Grateful to the @CancerGrand. Thank you to all of our team members! And Looking forward to the exciting work ahead.
Cancer Grand Challenges@CancerGrand

BREAKING NEWS: today we announce 11 teams selected to compete for our awards! Winners receive up to £20m each and the freedom to unleash their scientific creativity, conducting research that transcends geography and discipline - bit.ly/3cFyrZa #CancerGrandChallenges

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دریافت کریں

@StanfordMed @CR_UK @theNCI @CancerGrand @QMULMaths @QMBCI @anton_gh @michelle_monje