King L Hung

402 posts

King L Hung

King L Hung

@kinglhung

Biologist at Scripps, PhD at Stanford. Dynamics of genomes and cells.

San Diego, CA Katılım Şubat 2015
156 Takip Edilen1.2K Takipçiler
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King L Hung
King L Hung@kinglhung·
Our paper is out in @Nature! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11 nature.com/articles/s4158…
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Noah F. Greenwald
Noah F. Greenwald@NoahGreenwald·
So excited to see our work profiling the tumor microenvironment in triple negative breast cancer out @NatureCancer! Please give it a read, super proud of this one :) For a full description of what we found, see below for a detailed tweetorial. nature.com/articles/s4301…
Noah F. Greenwald@NoahGreenwald

I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) biorxiv.org/content/10.110…

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Sean Ku Wang
Sean Ku Wang@SeanKuWang·
Our paper is published in @CellReports! We apply a multi-omic framework to analyze nearly 2,000 noncoding variants at risk loci for age-related macular degeneration and nominate 59 variants as pathogenic. A great collab w/ @Jiaying_Gia @suragnair @anshulkundaje and @HowardYChang!
Cell Reports@CellReports

Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate causal variants in macular degeneration dlvr.it/TQSksf

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King L Hung
King L Hung@kinglhung·
@hhlee @CultivariumFRX Would be huge for the tissue regeneration field if you figure out how to deliver transgenes into different planarian species (sexual and asexual).
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Henry Lee
Henry Lee@hhlee·
DNA delivery is the biggest bottleneck for engineering the biology around us, and we barely have methods for a handful of organisms. @CultivariumFRX has been building an AI Scientist to close this gap. By studying how nature moves DNA, we're collecting data to learn the principles behind delivery so we can eventually infer methods for organisms that don't have any yet. Showcasing our early work with @ARIA_research's AI Scientist initiative. What biological systems or organisms would you like to work on? (Non-model organisms especially welcome)
ARIA@ARIA_research

AI can now generate scientific ideas at scale. But we need to know if the current state of the art can bridge the gap to physical validation – the phase constrained by what can be tested, how fast, and at what cost. To find out, we have doubled our investment in the AI Scientist programme to £6m. We're backing 12 projects to see if autonomous systems can reason, plan, and run experiments in the real world. These teams are testing the limits of automation on deliberately unforgiving problems: Alzheimer’s and cancer therapeutics, material discovery, and understanding the mechanisms behind battery degradation. Instead of looking for best-case scenarios, we’re looking for limits. Can these systems recover when experiments fail? Can they reason across disciplines? Can they decide what not to try? By doing this, we are learning what happens when machines are asked to do science, and exploring what that means for the future of discovery. Discover the projects: link.aria.org.uk/AIscifpx

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Long Lab
Long Lab@longlabstanford·
Most people eat small (~1-2% body weight) and frequent (2-3x/day) meals. But Burmese pythons 🐍🐍 can fast for >1 yr and eat 100% of their weight in a single meal. What happens in snakes after eating? What lessons they can teach us about human physiology? biorxiv.org/content/10.648…
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Cell
Cell@CellCellPress·
Now online! EcDNA-borne structural variants drive oncogenic fusion transcript amplification dlvr.it/TQClG0
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Stanford Medicine
Stanford Medicine@StanfordMed·
Stanford Medicine researchers found that tiny cancer-linked DNA circles “hitchhike” on chromosomes to spread during cell division. Blocking this attachment may offer a new avenue for future cancer therapies. med.stanford.edu/news/all-news/…
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King L Hung
King L Hung@kinglhung·
This was probably one of my crazier ideas early in grad school and was such a fun project to work on. Check out this awesome short video from @JuliaBauman2 highlighting this work!
Julia Bauman@JuliaBauman2

ecDNA biology is one of those weird, fascinating corners of bio that hook me every time there's a new result. So I loved reading about this one from @HowardYChang & Paul Mischel's labs in @Nature. Very interesting implications for design of non-diluting, non-integrating gene therapy vectors! Great work Venkat & @kinglhung 😀

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Chris Hsiung 熊
Chris Hsiung 熊@hsiung_chris·
My lab is recruiting postdoc candidates interested in CRISPR synthetic biology and functional genomics approaches to study and engineer tissue injury responses! hsiunglab.org
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nature
nature@Nature·
Nature research paper: Genetic elements promote retention of extrachromosomal DNA in cancer cells go.nature.com/4pkUpDE
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King L Hung
King L Hung@kinglhung·
It was great mentoring and working with Venkat Sankar on this project. Also great working with @HowardYChang, Paul Mischel, Aditi Gnanasekar, Ivy Wong, and other collaborators on this project. 11/11
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King L Hung
King L Hung@kinglhung·
Overall, we propose that ecDNA is not only selected in cancer because of oncogenes, it is also actively retained because of retention elements, allowing it to persist in a growing cancer cell population. 10/11
King L Hung tweet media
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King L Hung
King L Hung@kinglhung·
Our paper is out in @Nature! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11 nature.com/articles/s4158…
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Keşfet

@NatureCancer @SeanKuWang @CellReports @Jiaying_Gia @suragnair @anshulkundaje @HowardYChang @hhlee