Chan Wing Fuk

242 posts

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Chan Wing Fuk

Chan Wing Fuk

@ChanWingFuk

Postdoc @ACBDresearch @MonashUni | Haematopoiesis | Molecular immunology | 3D genome | Gene regulation | CRISPR | Former @WEHI_research

Melbourne, Victoria Tham gia Eylül 2019
116 Đang theo dõi77 Người theo dõi
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Chan Wing Fuk
Chan Wing Fuk@ChanWingFuk·
Still feeling it isn't real ... But thrilled that I got another @NatureComms paper with @rhyscienceallan ! A more robust CRISPR activation system TETact in activating transcription from CpG-methylated loci. doi.org/10.1038/s41467…
Rhys Allan@rhyscienceallan

💥💥Excited that our TETact study has now been published in @NatureComms nature.com/articles/s4146… @ChanWingFuk did a huge amount of new work in response to reviewers comments (e.g. multiple cell types, multiple genes activated in the same cell)

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Molecular Cell
Molecular Cell@MolecularCell·
Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II dlvr.it/TJy7Wq
Molecular Cell tweet media
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The Nobel Prize
The Nobel Prize@NobelPrize·
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
The Nobel Prize tweet media
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David R. Liu
David R. Liu@davidrliu·
Today we report in @natBME the eePASSIGE system, which uses evolved and engineered recombinases and prime editing to integrate large gene-sized DNA cargoes into the mammalian genome in an efficient, precise, and targeted manner. (1/13) drive.google.com/file/d/1WDMVqL…
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Rhys Allan
Rhys Allan@rhyscienceallan·
😀😀Excited to share our new paper published @genomeresearch ! Its been a long journey and huge effort from many @WEHI_research colleagues in particular @keeeeeeeeeeenan and @HDCoughlan who studied the importance of heterochromatin for 3D genome organisation👇
WEHI (Walter and Eliza Hall Institute)@WEHI_research

WEHI researchers have revealed that repairing disordered heterochromatin might aid in healthy #immune ageing. Loss of heterochromatin affects protein-making gene activity in specific areas of the cell nucleus. Published in Genome Research: m.genome.cshlp.org/content/34/4/5… (242) 🧵1/2

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David R. Liu
David R. Liu@davidrliu·
Today we report in @NatureBiotech an engineered virus-like particle system for in vivo delivery of prime editor protein-RNA complexes. This PE-eVLP platform can support therapeutic prime editing in animal models of genetic disease. /1 drive.google.com/file/d/1xd7Yzz…
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Sternberg Lab
Sternberg Lab@SternbergLab·
New pre-print from the Sternberg Lab! Transposon-encoded nucleases (TnpB/IscB) gave rise to the CRISPR-associated proteins (Cas9 and Cas12), but were TnpB-like proteins domesticated for other functions? 𝙔𝙀𝙎!! doi.org/10.1101/2023.1…
Sternberg Lab tweet media
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Molecular Cell
Molecular Cell@MolecularCell·
G-quadruplexes associated with R-loops promote CTCF binding dlvr.it/SvnGWT
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Molecular Cell
Molecular Cell@MolecularCell·
Online Now: G-quadruplexes associated with R-loops promote CTCF binding dlvr.it/StMCsd
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Nature Biotechnology
Nature Biotechnology@NatureBiotech·
High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition go.nature.com/43QCv0d
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Molecular Cell
Molecular Cell@MolecularCell·
Online Now: CTCF and R-loops are boundaries of cohesin-mediated DNA looping dlvr.it/St5qZN
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David R. Liu
David R. Liu@davidrliu·
Today we report in @NatureGenet a study led by the team of @JonathanYenPhD and Mitch Weiss @StJude that characterizes Cas9 nuclease and adenine base editing strategies to induce fetal hemoglobin expression, clinical approaches to treat sickle-cell disease & beta-thalassemia. 1/10
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Khám phá

@NatureBiotech @karasuerman1 @J_Maciejowski @FerreiraSilvaJ @connorjtou @CGM_MGH @harvardmed @natBME