Bode Lab

Happy to announce the first steps into NRPS/PKS engineering thanks to the work from Leonard and collaborations with the labs from Markus Kaiser and Michael Groll: Bioengineering of syrbactin megasynthetases for immunoproteasome inhib... sciencedirect.com/science/articl…

Leonard has applied the XUT NRPS engineering technology to solve the biosynthesis of the potent antibiotic odilorhabdin in collaboration with the Rolf Müller lab at @Helmholtz_HIPS. See his paper in @angew_chem: doi.org/10.1002/anie.2…

@mpi_marburg @HannahJeckel @IMPRS_Mic @knutdrescher Congratulations Hannah and Nadya! Well deserved!!!

Happy and proud to announce 📢 : Max Planck Society has awarded our two former MPI-TM Doctoral students the Otto Hahn Medal. Congratulations 🥳 to @HannahJeckel and 𝗡𝗮𝗱𝘆𝗮 𝗔𝗯𝗯𝗼𝗼𝗱! @IMPRS_Mic @knutdrescher @HelgeBode_Lab mpi-marburg.mpg.de/1394935/2024-0…

CRISPR now also available for Xenorhabdus and Photorhabdus for easy access to natural products and manipulation of their biosynthesis: Please see the paper from Alexander in Microbial Cell factories: rdcu.be/dDibN

And here is another cool story about trans-AT PKS engineering in the same issue science.org/doi/10.1126/sc… from the @piel_lab. Congratulations!!

Finally! After a long journey our latest NRPS engineering story is out at science.org/doi/10.1126/sc… thanks to the hard work of several members from the @HelgeBode_lab

With our newest preprint on engineering NRPS we succeeded in optimizing our first-of-its-kind biocombinatorial technology. Read more here: Guidelines for Optimizing Type S Non-Ribosomal Peptide Synthetases biorxiv.org/content/10.110…

The latest update for NRPS engineering, based on a evolutionary breakpoint within thiolation domains is out: doi.org/10.1101/2022.1…

Next round in "the many things that regulatory RNAs can do" - this time: controlling natural-product synthesis. Fantastic collaboration with the Bode lab (@HelgeBode_Lab) published today in @NatureMicrobiol nature.com/articles/s4156…

An awesome addition to polyketide biosynthesis. TE disguises itself as KS catalyzing branched polyketide formation. Read about Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide Gregatin A pubs.acs.org/doi/10.1021/ja…

Luckily, despite severe jet lag, Helge’s given a clear, nice talk @SIMB_Microbio #NaturalProducts on NRPS engineering with a more efficient approach. Showing the advantages of artificial docking domains in splitting and reconstructing the megasynthetases

Finally... more than a module! Great NRPS work from the Schmeing lab: Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility science.sciencemag.org/content/366/64…

Who makes antibiotics and how do NRPS work? See the Grininger/Bode group performance for kids here: rz.uni-frankfurt.de/68128012/Kinde…

🤔 could have submitted more

We have new, hypermodified peptides for you! Check out our aeronamide (from Microvirgula) & polygeonamide (from deep-rock metagenome🤘🎸) story at @NatureChemistry nature.com/articles/s4155… #RiPPs

Natural products go RNA: The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation cell.com/cell-chemical-…

Read Jörn‘s @nature #behindthepaper on how we developed the TransATor, a web tool for de novo structure predictions of trans-AT polyketides & why you need it go.nature.com/2jL18eL

The long-awaited TransAtor paper is out in @nchembio! TransAtor is a web application enabling de novo structural predictions of trans-AT PKS-derived polyketides. nature.com/articles/s4158…

First time to achieve peptide ligation in water, offering a chemical perspective of chicken-and-egg problem for the origin of life nature.com/articles/s4158…

Nice work by the Stanley-Wall lab: Pulcherrimin formation controls growth arrest of the Bacillus subtilis biofilm pnas.org/content/116/27…