Jacob F Degner

This paper helps calm my nagging worry that maybe we've all been wrong about genetics and drug success. By looking at a completely new dimension of drug success/failure, they reaffirm the effect we have seen using target-indication pair progression. nature.com/articles/s4158…

I see that the internet is loving this new paper, but has the internet read the wonderful opinion on it by my former postdoc Emily King? lnkd.in/gdtfTFcs

Genetic evidence halves the odds of early clinical trial stoppage 🧬💊 Published today in @NatureGenet, @lesya_rzvvsk trained a machine learning classifier to analyse the free-text reasons explaining why 28,842 clinical trials stopped 3 key points: nature.com/articles/s4158…

There is a position on my new team that just opened! We are looking for a creative and talented data scientist or statistical geneticist to help us use human genetics to drive value in drug development. careers.abbvie.com/en/job/lake-co…

We are building a new bioinformatics team at AbbVie that will work on design and optimization of novel biotherapeutics including rAAV based therapies. Please reach out and apply if you are interested! Here are the job postings: lnkd.in/gwNaTuyt lnkd.in/gsWbfEQn

@NeBanovich @athmapai @rogerpique @LB_Barreiro @fluca2406 @jtung5 Bummer!

@JacobFDegner @athmapai @rogerpique @LB_Barreiro @fluca2406 @jtung5 OH NO. I'm not there in person this year :(

Last in person BOG I was at #BOG19 #BOG22 ⁦@athmapai⁩ ⁦@rogerpique⁩ ⁦@LB_Barreiro⁩ ⁦@JacobFDegner⁩ ⁦@fluca2406⁩ With ⁦@jtung5⁩ on the 📸

@rogerpique Congrats Roger!

Very honored to be promoted to <no-adjectives/full> Professor! It would not have been possible without all my amazing colleagues, all current and past trainees, mentors and the support of my family. Thank you so much!

@jkpritch Interesting read! The narrative style is nice and reminds me of how scientific papers from a century ago read.

This is a real page-turner by Jesse Bloom, describing his detective work to track down deleted SARSCoV2 sequences from early in the pandemic.

Psychosocial experiences modulate asthma-associated genes through gene-environment interactions. Now epub in eLife. Lead by PhD student Justyna Resztak elifesciences.org/articles/63852

There's another job opening in my department! Please follow up with me if you are interested or know a good candidate! #hiring #jobs #bioinformatics #abbvie #pharma careers.abbvie.com/abbvie/jobs/21…

I'm excited to see the work from @jkpritch's former students and grand-students at the reunion symposium! Great talk from @HannahMoots on ancestry and relatedness of ancient Mediterranean civilization kicks it off.

How many SNPs do you need to estimate colocalization probabilities? One! Another great paper from Emily King's postdoc. bmcbioinformatics.biomedcentral.com/articles/10.11…

@rogerpique Congratulations Roger!!!! You deserve all the awards!

Very honored to be receiving this award! It would not have been possible without all the amazing colleagues and all current and past trainees. Thank you so much!

@mikelove @wolfgangkhuber I remember that night! I was completely lost when we met as I remember.

@wolfgangkhuber I once ran into @JacobFDegner on this trail on Burns Night. Ice + Burns Night made for slow going. because of the haggis. too much haggis

I was happy to contribute to this paper with my former postdoc Minal. She used text mining and some serious brute force to try to understand how our community is approaching GWAS fine mapping. Your feed back is welcome! sciencedirect.com/science/articl…

It's great to see the NCAA's enthusiasm for coalescent theory.

I'm looking to hire in the Computational Genomics - "Special Projects" group at AbbVie! The group addresses an an exciting and always changing set of projects and problems. Come join us! careers.abbvie.com/abbvie/jobs/21… @bioinfo44

@chchatham @AbePalmer Thanks! I think figure 2 gets at this point some. We see that genetic evidence is specifically predictive when it supports target relevance for a highly similar disease to the disease the drug(s) are being trialed for (trait-indication similarity).

@JacobFDegner @AbePalmer Very interesting! The contrast between GWAS & OMIM is interesting. Can/have you evaluated how much the putative advantage relates to genetic info in particular, vs a more general null H0: "drugs are more likely to progress when more is known about their targets (genetic or not)?"

Our paper on using human genetics to predict drug program success is out! eurekalert.org/pub_releases/2… journals.plos.org/plosgenetics/a…