King Lab

A team presents vaccines for H5 clade #influenza based on a stabilized H5 hemagglutinin stem, which improves the breadth and depth of antibody responses and protects against #H5N1 challenge in immunized mice. @KingLabIPD @anniedosey @UWBiochemistry scim.ag/4reeKei

🚨 new paper alert 🚨 Here we demonstrate increased anti-RBS neutralizing responses elicited by stabilized influenza H5 immunogens: bit.ly/4u8UxJl

Happy New Year! We are delighted to share with you our newest @biorxivpreprint, in which we describe the de novo design of protein nanoparticles with structures tailored to specific applications. Long a dream, it is now reality! biorxiv.org/content/10.648…

Yesterday Dane Zambrano successfully defended her thesis on hybrid lipid-protein nanoparticles! Excellent work Dr. Dane!!

🚨new paper alert🚨 Here, we show how recently developed ML tools can be leveraged to design self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the oligomeric building blocks. Read more @PNASNews: doi.org/10.1073/pnas.2…

You can also learn more at our @UWproteindesign blog post: bit.ly/3KKnObo.

🚨 new paper in @ScienceTM 🚨 Here, we describe and evaluate a "best-of-both-worlds" vaccine technology platform that combines the benefits of mRNA vaccines and computationally designed protein nanoparticle immunogens: bit.ly/47s7btG.

mRNA vaccines 🤝 designed nanoparticle immunogens

Couldn't have asked for a lovelier day to break ground in our new lab downtown!🌞

Thanks to Aia, Syed, Dixie, and James for joining us this summer as Rosetta Commons Undergraduate Researchers! We loved working with you these past 10 weeks and wish you the best as you head back home!

Another day, another @biorxivpreprint! Here, we show how new machine learning tools can be leveraged to design new self-assembling protein nanoparticle immunogens in the absence of experimentally determined structures of the building blocks. biorxiv.org/cgi/content/sh…

🚨 New paper alert! 🚨 Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM

You can also learn more in the most recent @UWproteindesign blog post: ipd.uw.edu/2025/08/creati…

🚨 new paper alert 🚨 We present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances! This project was led by Dr. Sanela Rankovic is out now in Nature Materials: tinyurl.com/yj8t476d

We’re looking for early stage investigators (Sr. Postdocs, Instructors, Asst Profs, etc) to join our ReVAMPP Center designing vaccines and antibodies against paramyxoviruses and bunyaviruses! Read more and apply here: tinyurl.com/MLvax-ESI-app

The IPD is hiring a new Assistant to the Director! This role provides complex administrative support to IPD leadership and is crucial to keeping operations running. Apply today! bit.ly/4kyguvn

Congrats on graduating Priya! After working in the lab for 3 years on vaccine adjuvants targeting the CD40 signaling pathway in germinal centers, she earned a Distinguished Researcher in Biochemistry award! Now she's off to work on flu vaccines at NIAID’s Vaccine Research Center.

🚨 new paper alert 🚨 Here, we designed, characterized, and evaluated >100 #malaria vaccines built on our two-component nanoparticle platform! This collaborative project was led by Dr. Mark Langowski and is out now in npj Vaccines: bit.ly/3Gk37B2

@florian_krammer It is! Graduating students get to choose their 3D protein print. Cam has been doing a lot of work to improve the stability and expression of TLRs, so she chose one of her designs. Good eye!

@KingLabIPD Is that a toll-like receptor?

There's a new doctor in town, Cameron Criswell defended her PhD thesis last week! 🥳 Congratulations on all your hard work Dr. Criswell!