chalderman

@ohiotate @BarstoolBigCat How does @StoolMintzy have a job seriously

Why do I do this to myself everyday

@anishmoonka @JWVegas1 Imagine

Your dog could soon get a daily pill that slows aging. 1,300 dogs are already testing it across 70 vet clinics, and it just passed its second FDA safety review in January. The drug is LOY-002. A San Francisco startup called Loyal makes it. Celine Halioua started the company in 2019 when she was 24. They have raised $250 million so far, including $100 million in February from Baillie Gifford, the same firm that bet early on Tesla and Amazon. The simplest way to explain what it does: if you put a dog on a strict diet where it eats way less food, that dog tends to live about two years longer. Cancer and arthritis both show up later. The body just ages more slowly. LOY-002 gives the dog those exact benefits without actually eating less. The dog keeps its appetite and its weight; it just ages more slowly. The trial is called STAY. Half the dogs get a beef-flavored pill every day, and the other half get a fake version that looks and tastes the same. The FDA reviewed safety data from over 400 dogs. Zero serious side effects, even at five times the normal dose. Loyal has now cleared two of three hurdles for conditional approval, which basically means they could start selling the drug while the full trial keeps going. The last piece, manufacturing, goes to the FDA in 2027. One thing the tweet gets a bit wrong: the pill is for senior dogs aged 10 and older, at least 14 pounds. And Loyal is being careful about the "years" claim. Right now, they are saying at least one extra year of healthy life. They want to prove more, but the trial needs to finish first. If LOY-002 gets approved, it would be the first drug the FDA has ever cleared to slow aging in any species, human or animal. Loyal also has two more drugs coming for big breeds like Great Danes and Rottweilers. Those dogs die younger partly because of a hormone called IGF-1, which makes them grow fast but also wears their bodies out quicker. And a separate project backed by a $7 million grant from the NIH (the agency that funds medical research) is testing a human organ transplant drug called rapamycin in 580 dogs to see if it slows aging, too. The global pet care market hit $261 billion last year. A once-a-day pill that gives your dog even one extra healthy year could easily become one of the best-selling veterinary drugs on the planet.

@krabs_bookit That’s bad aaa

Who is buying this shit at the Yankees team store 😂

@BookitWithTrent @RagansCoke Please stop betting royals man

It was always Coke Ragans. @RagansCoke

@TheDegenWeekly Sir I’d like to report a murder

I don’t think I’ve seen this guy win a bet

@JayNussIV They’re getting slapped

This will be the easiest wager in your gambling career. 🐻Missouri State -1.5🐻 I like the Bears all the way up to -7.5 if they offer alt lines. I’m serious.

Shane Gillis had Joe Rogan and the whole room in TEARS roasting a guy with the TIGHTEST chain ever 😭💀👀 “You grew into it like one of these African ladies” 🤣

@ChrisClarkNFL Pats AFC title game vs Brady (no doubt OT back then)

Any answer that isn’t the Eagles stomping KC doesn’t make sense…would be the only three peat champion…

@kingkrabbyp you’ve been quiet

@h8rproof82 @cdotharrison @ryanJayhawk Don’t cash out

@cdotharrison @ryanJayhawk DO NOT CASH OUT

THE BEAT GOES ON

@BBQChiefs Brisket burger at Wolfpack bbq

Best place to get a Burger in Kansas City?

@martymush That doesn’t say Marty Mush

We're beating the shit out of UConn and people are questioning where I went to school

Ben McCollum on Bennett Stirtz: “It was 4 years of work and being coached by me and earning his way to the NBA. He’ll play in the NBA. How ridiculous is that story? He was at Liberty High School and nobody wanted him, and now he’s gonna work his way into the NBA. It’s been fun.”

@shadybiev How is +21.5 not safe in an elite 8 matchup

Wake up. Bet the favorite. Parlay the favorites. Go up massive coin. Repeat.

@steaakfriend Right answer

@chalderman No

Line to the bathroom longer than the line to suck Tom Izzos dick every March.

Enjoy doin that weekly podcast with Nadu @Return_Of_RB

@Ogilvy2006 @krabs_bookit They don’t watch D2 sports

@chalderman @krabs_bookit ? 6x D2 football national champion 4x D2 basketball national champion? If they don’t know NWMSU then they don’t watch sports

Ben McCollum might be the best college basketball coach in the country He was coaching at Northwest Missouri State two years ago

@stoolpresidente @_willcompton Iowa is hot and has the better coach by far

That’s what I get for believing in Nebraska. This guy is everything @_willcompton wants to be. Iowa owns Nebraska. I’m an idiot. #GBR