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🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧵
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Parker Singleton
4K posts
Parker Singleton
@singletonion
dad - senior scientist at https://t.co/yahvMgGrLa - psychedelics and other fun stuff - aspiring urban homesteader - https://t.co/CaARmkGGQn
Greenville, SC Tham gia Mart 2018
1.2K Đang theo dõi1.9K Người theo dõi
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We think of white matter as highways of the brain. But when we followed development along those highways, we were surprised. The journey is more complex than we thought. My PhD paper, “Two Axes of White Matter Development”, is now out in @NatureComms!🧠
🔗bit.ly/wm2axes
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I missed this somehow - Four weekly doses of methylone with no psychotherapy improves PTSD symptoms compared to placebo. transcendtherapeutics.com/wp-content/upl…
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I got to work with a psychedelic dream team on this! @RCarhartHarris, Conor Liston, Ginger Nicol, and Michael Bogenschutz
Very proud of what came out of it - - a rigorous, insightful, and authoritative review IMHO
Nature Medicine@NatureMedicine
New Review: The science of #psychedelic medicine. Joshua Siegel & colleagues integrate mechanistic knowledge with clinical evidence across neuropsychiatric indications — highlighting challenges, controversies, and opportunities. @realJoshSiegel @RCarhartHarris @nyugrossman nature.com/articles/s4159…
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Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin
nature.com/articles/s4138…
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I’m happy to report our paper, “Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin”, is now published in Molecular Psychiatry.
nature.com/articles/s4138…
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Important I think for the psychedelics fMRI peeps to be aware of: biorxiv.org/content/10.648…
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A new pre-print from my lab + colleagues. Defining ‘psychedelic’ osf.io/preprints/psya… via @OsfFramework
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New paper with @eselster — Why do people believe in a flat earth, pseudoscience, or supernatural entities? Prevailing approaches point to psychological biases (like agency detection) or social dynamics (like signaling). Our claim: experience matters, too! @TrendsCognSci
Eli Elster@eselster
Why do humans believe in things that seem to lack all supporting evidence, like conspiracy theories, spirits and psuedoscience? In a new Review for @TrendsCognSci , @mnvrsngh and I argue that experience plays a crucial role in shaping these 'extraordinary beliefs.' Link in 🧵
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Psilocybin research seems on slope of enlightenment:
-large trials w/ active controls
-multi-site replications
-meta-analyses on risks/benefits
Ibogaine seems it's cresting the peak of the hype cycle: -small uncontrolled studies
-anecdotes outpacing evidence
-understudied risks
David B. Yaden@ExistWell
Is the psychedelic hype bubble about to burst? Might that be best for the field? In a new @JAMAPsych article w/ me, @jpotash1, & R. Griffiths, we argue for moving beyond overly negative AND positive extremes to embrace the actual evidence @JHPsychedelics jamanetwork.com/journals/jamap…
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On the second anniversary of Roland Griffiths' death, I'm taking the opportunity to reflect on the value of scientific curiosity and the virtue of constant curiosity about life in general that he seemed to me to so consistently embody.
David B. Yaden@ExistWell
It's been a week since my advisor, colleague, & friend Roland Griffiths passed away. Even though it was expected, his death still came as a shock and I've been trying to find the right words. I wrote this to honor one of his exceptional qualities--his spirit of radical curiosity:
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A visit to a headache-inducing pharmacy, looking for headache-resolving medicine.
Uji 🇯🇵
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one of the coolest works I've ever had the joy of being a part of! hats off to Parker on this thought-provoking piece.
D. Parker Kelley@sequencemyneuro
In the Allostatic Triage Model of Psychopathology (ATP Model), we propose a novel concept: Allostatic Triage: the stress-induced redistribution of energy from CNS networks optimizing long-term outcomes to those supporting short-term survival.
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🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵
nature.com/articles/s4159…
#Neuroscience #Psychedelics #BrainImaging
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How does energy keep us alive?
Our bodies are resistive energetic circuits where electrons flow from food→oxygen in our mitochondria. It's only through energy resistance (éR) - like electrical resistance - that transformation of energy into life is possible.
The Energy Resistance Principle ⎸ ERP explains how this happens. In this paper, we cover the implications of fine-tuning éR for health, disease, aging, and the human experiences make up the mind.
authors.elsevier.com/a/1luVK5WXUlaY…
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New @ImagingNeurosci from @BrandonTaraku:
Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression direct.mit.edu/imag/article/d…
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Interested in the mechanisms shaping the extraordinary complexity of the connectome?
Then check out our new preprint, lead by @_francisnormand with a stellar team showing how geometry constrains connectome architecture:
biorxiv.org/content/10.110…
Peep the 🧵
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"We are not anti-psychedelics; we just want historical accuracy."
Psychedelics, Eleusis, and the Invention of Religious Experience
liebertpub.com/doi/10.1177/28…
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Musical Chess teaches toddlers and big kids with hands-on fun greenvilleonline.com/story/upstatep…
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