Alexandre Dumoulin @axonsalex.bsky.social

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Alexandre Dumoulin @axonsalex.bsky.social

Alexandre Dumoulin @axonsalex.bsky.social

@AxonsAlex

Developmental Neurobiologist @UZH_Science | Microscopy Enthusiast | Science communication | Bluesky: @axonsalex.bsky.social Youtube: @AlexNeuroHealth

Axonal growth cone 加入时间 Ağustos 2020
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Alexandre Dumoulin @axonsalex.bsky.social
Alexandre Dumoulin @axonsalex.bsky.social@AxonsAlex·
Finally out! 🥳We added a lot of rescue experiments. We now show that Arl13b needs to locate to commissural neurons primary cilium for proper rostral turning of axons. We also further characterized Shh retrograde transport to the soma of comm. neurons. journals.biologists.com/dev/article/do…
Alexandre Dumoulin @axonsalex.bsky.social tweet media
Alexandre Dumoulin @axonsalex.bsky.social@AxonsAlex

Delighted to share our latest preprint entitled « A cell-autonomous role for #primarycilia in long-range commissural #axonguidance ». We propose a mechanism involving the neuronal primary cilium during axon guidance at an intermediate target. tinyurl.com/2s4aykbb 🧵(1/7)

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Alexandre Dumoulin @axonsalex.bsky.social
Alexandre Dumoulin @axonsalex.bsky.social@AxonsAlex·
The tissue shown here is an ex vivo culture of intact spinal cord from a🐣embryo, allowing us to observe these processes in a controlled yet physiologically relevant setting.What looks like a simple crossing event emerges from complex and tightly regulated cellular processes.
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Alexandre Dumoulin @axonsalex.bsky.social
Alexandre Dumoulin @axonsalex.bsky.social@AxonsAlex·
During development, these neurons extend long projections that grow toward the midline, cross it, and then turn to grow along the length of the spinal cord. This coordinated behavior is essential for establishing connectivity between the two sides of the nervous system.
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Alexandre Dumoulin @axonsalex.bsky.social
Alexandre Dumoulin @axonsalex.bsky.social@AxonsAlex·
These are dI1 neurons, a well-studied class of spinal interneurons that have been used for more than 30 years to uncover fundamental mechanisms of axon guidance and neural circuit formation.
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Alexandre Dumoulin @axonsalex.bsky.social
Alexandre Dumoulin @axonsalex.bsky.social@AxonsAlex·
This time-lapse captures 17h of axonal growth from a chick dorsal root ganglion explant, seen through the actin cytoskeleton using live imaging. I just submitted this video to the Nikon Small World in Motion competition. Today is the last day to upload yours!😉 #neuroscience
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Alexandre Dumoulin @axonsalex.bsky.social 已转推
Emma Lundberg
Emma Lundberg@Prof_Lundberg·
I’m very excited to finally present something we’ve been working on for the past couple of years – a spatial proteome map of primary cilia, released in @ProteinAtlas today. Amazing teamwork led by @jn_hansen Check out our preprint doi.org/10.1101/2024.1…
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Alexandre Dumoulin @axonsalex.bsky.social 已转推
Elisabeth Bik
Elisabeth Bik@MicrobiomDigest·
The punishment for science misconduct is …. nothing. All these men are still running labs / paid professors.
Dan Elton@moreisdifferent

List of high-level Alzheimer's researchers accused of credible fraud:🧵 #1 - Marc Tessier-Lavigne Genentech pointed out problems in his 2009 Nature paper in 2012. After an expose by @tab_delete, he had to resign from Stanford Presidency, but can still run lab and do research.

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Alexandre Dumoulin @axonsalex.bsky.social 已转推
@FrogWranglers
@FrogWranglers@frogwranglers·
Baby you’re a fiiiiirework!!! Explanted Xenopus neural crest cell, microtubules (green) and actin (magenta). Imaging in frogs rocks- this is done room temp, no incubation, no problem. 🐸🔬✨ By Micaela Lasser, Helen Willsey @goodfrognosis Lab @zeiss_micro LSM980 fast airyscan
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Elkhan Yusifov
Elkhan Yusifov@yusifov_elxan·
Thanks for selecting our image for "Images of Distinction" award 😎 Developing nervous system in the eye of a 7-day-old chick embryo | 2024 Photomicrography Competition | Nikon’s Small World: nikonsmallworld.com/galleries/2024…
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Alexandre Dumoulin @axonsalex.bsky.social
Alexandre Dumoulin @axonsalex.bsky.social@AxonsAlex·
@lreymond2 Thanks Luc! It is again the Pkmem 555 probe (magenta) and a mStayGold fusion protein (green). I don't have to correct my recordings for breaching anymore! there is no apparent bleaching to be seen...🤯🤯🤯
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Luc Reym⌬nd
Luc Reym⌬nd@lreymond2·
@AxonsAlex this is really cool and impressive! with 1 frame/sec in 2 channels for 10 minutes, you are an expert phototoxicity manager! which fluorophores/FPs are you using?
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